Sapporo Ryokuai Hospital

Sapporo, Japan

Sapporo Ryokuai Hospital

Sapporo, Japan
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Oka T.,Matsuyama University | Enoki H.,Research Institute of Clinical and Social Pharmacy | Tokimoto Y.,Osaka University of Human Sciences | Kawanishi T.,Sapporo Ryokuai Hospital | And 3 more authors.
BMC Public Health | Year: 2017

Background: In Japan, an estimated 400,000 people have the hepatitis B virus (HBV), many of whom were infected as a result of group vaccinations. People with HBV face many challenges, including disease progression, employment-related difficulties, and increased medical expenses. The relationship between HBV victims' daily life suffering and poverty associated with HBV-related employment changes has not been examined. We aimed to clarify the employment-related hardships experienced by Japanese HBV victims, and the relationships between these hardships and daily life suffering, including poverty, through qualitative and quantitative analyses. Methods: The study population comprised 11,046 people infected with HBV via group vaccination who filed lawsuits in Japan's District Courts by 2014. First, we conducted a qualitative study (2013) using the KJ method, with 107 participants (68 men, mean age 58.9 years; 39 women, mean age 55.3 years). Semi-structured interviews were conducted covering participants' current condition, treatment, medical expenses, and life difficulties (employment- and family-related problems). In 2014, we conducted a quantitative study. We mailed questionnaires to the entire study population, investigating the topics covered in the interviews (response rate 60.1%). Daily life suffering was determined by responses to the question "What do you think about your everyday life situation?" We performed binomial logistic regression analyses to verify the relationships between daily life suffering and disease, employment, and income status. Results: Interview data were integrated into seven islands: intention to work, lack of understanding of HBV in the workplace, inability to buy life insurance, burden due to medical expenses, life failure, dissatisfaction with the system, and wishing for life balance. The quantitative analyses showed significant positive correlations between daily life suffering and liver cancer (odds ratio [OR] 1.47, 95% confidence interval [CI]: 1.00-2.17, p < 0.05), being a part-time/casual employee (OR 1.46, 95% CI: 1.11-1.92 p < 0.01), and an income below the national average (p < 0.01). Conclusion: We qualitatively and quantitatively demonstrated that employment-related hardships and daily life suffering are prevalent in people with HBV. Their likelihood of experiencing distress in daily life increases with increasing medical expenses, insecure employment status (e.g., job loss) attributable to HBV, and the resulting poverty. © 2017 The Author(s).


Noumura Y.,Hokkaido University | Kamishima T.,Hokkaido University | Sutherland K.,Hokkaido University | Nishimura H.,Sapporo Ryokuai Hospital
British Journal of Radiology | Year: 2017

Objective: Measurement of visceral adipose tissue (VAT) needs to be accurate and sensitive to change for risk monitoring. The purpose of this study is to determine the CT slice location where VAT area can best reflect changes in VAT volume and body weight. Methods: 60 plain abdominal CT images from 30 males [mean age (range) 51 (41-68) years, mean body weight (range) 71.1 (101.9-50.9) kg] who underwent workplace screenings twice within a 1-year interval were evaluated. Automatically calculated and manually corrected areas of the VAT of various scan levels using "freeform curve" region of interest on CT were recorded and compared with body weight changes. Results: The strongest correlations of VAT area with VAT volume and body weight changes were shown in a slice 3 cm above the lower margin of L3 with r values of 0.853 and 0.902, respectively. Conclusion: VAT area measurement at a single level 3 cm above the lower margin of the L3 vertebra is feasible and can reflect changes in VAT volume and body weight. Advances in knowledge: As VAT area at a CT slice 3 cm above the lower margin of L3 can best reflect interval changes in VAT volume and body weight, VAT area measurement should be selected at this location. © 2017 The Authors. Published by the British Institute of Radiology.


Nakajima F.,Nemuro City Hospital | Matsuoka K.,Nemuro City Hospital | Ogawa T.,Nemuro City Hospital | Nomura H.,Kushiro Koujinkai Memorial Hospital | Araya J.,Sapporo Ryokuai Hospital
Japanese Journal of Cancer and Chemotherapy | Year: 2011

A 42-year-old female underwent surgery for cancer of the left breast (T3N2M0) in February 2003, and FEC 70, followed by CMF, was administered as adjuvant therapy. In January 2009, second-line chemotherapy with weekly paclitaxel therapy was started after multiple pleural and bone metastatic lesions had been found. Despite this treatment, she required radiation therapy for the growth of bone metastatic lesions. As paclitaxel apparently had no useful effect on the lesions, S-1 chemotherapy, given as third-line therapy starting in December 2009, was considered useful for disease control without progression demonstrated by PET evaluation.


Araya J.,Sapporo Ryokuai Hospital | Nomura H.,Hoshigaura Hospital | Nakajima F.,Betsukai Municipal Hospital
Journal of Japanese Society of Gastroenterology | Year: 2016

A 79-year-old woman was admitted for investigation of epigastric pain and jaundice. Abdominal computed tomography showed a common bile duct stone with a needle-like calcification. Endoscopic sphincterotomy was performed, and the stone was extracted from the common bile duct After endoscopic sphincterotomy, laparoscopic cholecystectomy was performed. Pathological findings and component analysis of the stone suggested that it was formed from a fish bone. We report a rare case of a common bile duct stone formed from a fish bone.


Kominami K.,Sapporo Ryokuai Hospital | Nishijima H.,Sapporo Ryokuai Hospital | Imahashi K.,Sapporo Ryokuai Hospital | Katsuragawa T.,Sapporo Ryokuai Hospital | And 3 more authors.
Medicine (United States) | Year: 2015

We assessed the correspondence between the V-slope ventilatory threshold (VT) and the lactate threshold (LT) by using a distinctive slow submaximal ramp protocol to ensure that sufficient data points exist around the threshold. Twenty healthy young men participated. A submaximal test based on a prior maximal test (25 watt/min, medium ramp) was performed with an individual slow-ramp protocol (6-17 watt/min, slow ramp), in which the time to reach the VT workload was estimated to be 10 minutes. The LT was determined visually by detecting a rise above the resting value, without or with log-log transformation (LT1, LT2). The point at which the blood lactate exceeded the minimal difference (LMD) of 2 resting values was also calculated. The VT appeared significantly earlier under the slow-ramp protocol compared to the medium-ramp protocol (from 19.3±3.9 to 15.0±4.0 mL/kg/min VO2, P<0.001). The mean LT1 and LT2 values appeared even earlier than the VT (LT1, P=0.004; LT2, P=0.002) (LT1, 11.9; LT2, 13.4; LMD, 17.0; VT, 15.0 mL/kg/min VO2). As the mean % of peak VO2, each occurred at 29.9%, 33.7%, 42.5%, and 37.8%. The VT correlated significantly with LT1, LT2, and LMD (r=0.61, 0.64, 0.80; P=0.004, 0.002, <0.001). Mean blood lactate showed a similar trend (1.30, 1.43, 1.81, 1.68 mmol/L, respectively). Furthermore, the DVO2/D work rate slope increased (from 10.8±0.9 to 11.5±0.9; P=0.01) with the slow ramp, and the lower LT was associated with the greater increase in slope (LT1, r=-0.47, P=0.03; LT2, r=-0.59, P=0.005), that is, the lower LT was an indication that on the faster medium ramp the slope would decrease. The LMD and VT did not show this relation. Under slow-ramp exercise testing in healthy young men, the VT appeared earlier than under medium-ramp exercise testing. In addition, the LT appeared even earlier (at approximately 30% of peak VO2) than the VT, although they correlated. This very early onset of LT was, however, associated with evidence of reduced oxygen uptake kinetics. Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.


Araya J.,Sapporo Ryokuai Hospital | Nomura H.,Sapporo Ryokuai Hospital | Nakajima F.,Sapporo Ryokuai Hospital
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology | Year: 2016

A 79-year-old woman was admitted for investigation of epigastric pain and jaundice. Abdominal computed tomography showed a common bile duct stone with a needle-like calcification. Endoscopic sphincterotomy was performed, and the stone was extracted from the common bile duct. After endoscopic sphincterotomy, laparoscopic cholecystectomy was performed. Pathological findings and component analysis of the stone suggested that it was formed from a fish bone. We report a rare case of a common bile duct stone formed from a fish bone.


Cell-mediated cytotoxicity assays are widely implemented to evaluate cell-mediated cytotoxic activity, and some assays are analyzed using the analogy of enzyme kinetics. In the analogy, the effector cell is regarded as the enzyme, the target cell as the substrate, the effector cell-target cell conjugate as the enzyme-substrate complex and the dead target cell as the product. However, the assumptions analogous to those of enzyme kinetics are not always true in cell-mediated cytotoxicity assays, and the parameter analogous to the Michaelis-Menten constant is not constant but is dependent on the number of effector cells. Therefore I present novel mathematical models for cell-mediated cytotoxicity assays without applying enzyme kinetics. I instead use combinations and probability, because analysis of cell-mediated cytotoxicity assays by applying enzyme kinetics seems controversial. With my original models, I demonstrate simulations of the data in previously published papers. The results are exhibited in the same forms as the corresponding data. Comparing the simulation results with the published data, the results seem to agree well with the data. From simulations of cytotoxic assays with bulk effector cells, it appears that bystanders in bulk effector cells increase both the cytotoxic activity and the motility of effector cells. © 2011 Elsevier Ireland Ltd.


The basic model for chronic hepatitis B virus (HBV) or hepatitis C virus (HCV) infection during therapy enables us to analyze short-term viral kinetics. However, the model is not useful for analyzing long-term viral kinetics. Here, I suggest a new model that was obtained by introducing Michaelis-Menten kinetics into the basic model. The new model can exhibit long-term viral kinetics without rebound and oscillation, unlike the basic model. The value of the parameter K in the new model is analogous to the Michaelis constant Km and is predicted to be approximately less than 1010/ml. © 2013 Elsevier Ltd.


Cell-mediated cytotoxicity assays are widely implemented to evaluate cell-mediated cytotoxic activity, and some assays are analyzed using the analogy of enzyme kinetics. In the analogy, the effector cell is regarded as the enzyme, the target cell as the substrate, the effector cell-target cell conjugate as the enzyme-substrate complex and the dead target cell as the product. However, the assumptions analogous to those of enzyme kinetics are not always true in cell-mediated cytotoxicity assays, and the parameter analogous to the Michaelis-Menten constant is not constant but is dependent on the number of effector cells. Therefore I present novel mathematical models for cell-mediated cytotoxicity assays without applying enzyme kinetics. I instead use combinations and probability, because analysis of cell-mediated cytotoxicity assays by applying enzyme kinetics seems controversial. With my original models, I demonstrate simulations of the data in previously published papers. The results are exhibited in the same forms as the corresponding data. Comparing the simulation results with the published data, the results seem to agree well with the data. From simulations of cytotoxic assays with bulk effector cells, it appears that bystanders in bulk effector cells increase both the cytotoxic activity and the motility of effector cells.


PubMed | Sapporo Ryokuai Hospital
Type: Journal Article | Journal: Computers in biology and medicine | Year: 2013

The basic model for chronic hepatitis B virus (HBV) or hepatitis C virus (HCV) infection during therapy enables us to analyze short-term viral kinetics. However, the model is not useful for analyzing long-term viral kinetics. Here, I suggest a new model that was obtained by introducing Michaelis-Menten kinetics into the basic model. The new model can exhibit long-term viral kinetics without rebound and oscillation, unlike the basic model. The value of the parameter K in the new model is analogous to the Michaelis constant Km and is predicted to be approximately less than 10(10)/ml.

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