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Endo T.,Health Sciences University of Hokkaido | Hayasaka M.,Sapporo Higashi Tokushukai Hospital | Hisamichi Y.,Health Sciences University of Hokkaido | Kimura O.,Health Sciences University of Hokkaido
Marine Pollution Bulletin | Year: 2013

We analyzed stable isotope ratios of carbon (δ13C) and nitrogen (δ15N) as well as mercury (Hg) concentration in the scalp hair of Japanese who consumed whale meat and those who did not, and investigated the relationships among the δ13C and δ15N values and Hg concentration. The average δ15N and δ13C values of whale meat-eaters (10.11‰ and -18.5‰) were significantly higher than those of non-eaters (9.28‰ and -18.9‰), respectively. The average Hg concentration of whale meat-eaters (20.6μg/g) was significantly higher than that of non-eaters (2.20μg/g). Significant positive correlations were found between the δ13C and δ15N values and between the δ15N value and Hg concentration in the hair of whale meat-eaters, while the correlation between the δ15N value and Hg concentration was not statistically significant in the non-eaters. The consumption of whale meat may increase Hg concentration as well as δ15N and δ13C values in scalp hair. © 2013 Elsevier Ltd.

Kimura O.,Health Sciences University of Hokkaido | Tsukagoshi K.,Hijirigaoka Hospital | Hayasaka M.,Sapporo Higashi Tokushukai Hospital | Endo T.,Health Sciences University of Hokkaido
Archives of Toxicology | Year: 2012

We investigated whether the uptake of triclopyr (3, 5, 6-trichloro-2- pyridinyloxyacetic acid) and dicamba (3,6-dichloro-2-methoxybenzoic acid) across the apical membrane of Caco-2 cells was mediated via proton-linked monocarboxylic acid transporters (MCTs). The uptake of triclopyr from the apical membranes was fast, pH-, temperature-, and concentration dependent, required metabolic energy to proceed, and was competitively inhibited by monocarboxylic acids such as benzoic acid and ferulic acid (substrates of l-lactic acid-insensitive MCTs), but not by l-lactic acid. Thus, the uptake of triclopyr in Caco-2 cells appears to be mediated mainly via l-lactic acid-insensitive MCTs. In contrast, the uptake of dicamba (a benzoic acid derivative) was slow, and it was both pH- and temperature dependent. Coincubation with ferulic acid did not decrease the uptake of dicamba, although coincubation with benzoic acid moderately decreased it. The uptake of dicamba appears to be mediated mainly via passive diffusion, which is in contrast to the uptake of benzoic acid via MCTs. We speculate that the substituted groups in dicamba may inhibit uptake via MCTs. © 2011 Springer-Verlag.

Furukori M.,Asahikawa University | Imai K.,Asahikawa University | Karasaki H.,Sapporo Higashi Tokushukai Hospital | Watanabe K.,Asahikawa University | And 4 more authors.
World Journal of Gastroenterology | Year: 2014

AIM: To present our experiences in studying the clinicopathological features of small nonfunctioning pancreatic neuroendocrine tumors (NF-pNETs). METHODS: The subjects included 9 patients with NFpNETs who underwent pancreatectomy between April 1996 and September 2012. The surgical procedure, histopathological findings, and prognosis were assessed. RESULTS: All tumors were incidentally detected by computed tomography. The median diameter was 10 mm (5-32 mm). One patient was diagnosed with von Hippel-Lindau disease, and the others were sporadic cases. For the histopathological findings, 7 patients were G1; 1 patient was G2; and 1 patient, whose tumor was 22 mm, had neuroendocrine carcinoma (NEC). One patient who had a tumor that was 32 mm had direct invasion to a regional lymph node and 1 patient with NEC, had regional lymph node metastases. Six of the 7 patients with sporadic NF-pNETs, excluding the patient with NEC, had tumors that were smaller than 10 mm. Tumors smaller than 10 mm showed no malignancy and lacked lymph node metastasis. CONCLUSION: Sporadic NF-pNETs smaller than 10 mm tend to have less malignant potential. These findings suggest that lymphadenectomy may be omitted for small NF-pNETs after further investigation. © 2014 Baishideng Publishing Group Inc. All rights reserved.

Kamijo Y.,Kitasato University | Takai M.,Kitasato University | Fujita Y.,Iwate Medical University | Hirose Y.,Emergency and Critical Care Medical Center | And 5 more authors.
Internal Medicine | Year: 2014

Objective We conducted a multicenter retrospective survey of patients poisoned by synthetic chemicals (SCs) in Japan.Methods Letters were sent to 467 emergency facilities requesting participation in the study, and questionnaires were mailed to facilities that agreed to participate.Patients The study participants were patients who were transported to emergency facilities between January 2006 and December 2012 after consuming SC-containing products.Results We surveyed 518 patients from 60 (12.8%) facilities. Most patients were male (82.0%), in their 20s or 30s (80.5%), and had inhaled SCs (87.5%) contained in herbal products (86.0%). Harmful behavior was observed at the scene of poisoning for 56 patients (10.8%), including violence to others or things in 32, traffic accidents in seven, and self-injury or suicide attempts in four. Other than physical and neuropsychiatric symptoms, some patients also had physical complications, such as rhabdomyolysis (10.0%). Of the 182 patients (35.1%) admitted to hospitals, including 29 (5.6%) who needed respirators, all of the 21 (4.1%) hospitalized for at least seven days were male, and 20 had physical complications (rhabdomyolysis, 12; liver dysfunction, 5; renal dysfunction, 11; and physical injuries, 3). Most patients (95.6%) completely recovered, although 10 (1.9%) were transferred to a psychiatric department or hospital, and three (0.6%) were handed over to the police due to combative or violent behavior. SCs such as synthetic cannabinoids, synthetic cathinones, or methoxetamine were detected in 20 product samples.Conclusion Consuming products containing SCs can result in physical complications, including rhabdomyolysis, injuries, and physical or neuropsychiatric symptoms, which may require active interventions, such as respirator use or prolonged hospitalization. © 2014 The Japanese Society of Internal Medicine.

Suda T.,Sunagawa City Medical Center | Yoshikawa M.,Sapporo Higashi Tokushukai Hospital | Kalo S.,Sunagawa City Medical Center
Japanese Journal of Plastic Surgery | Year: 2014

Diabetes mellitus increases the risk of gangrene in affected patients. When gangrene is accompanied by osteomyelitis of the tarsal bone, a major amputation and subsequent reliance on prostheses and a wheelchair cannot be avoided. However, adapting to prostheses is often difficult for elderly patients. We encountered a case of diabetic gangrene in an elderly patient with calcaneal osteomyelitis. The condition was successfully treated by removing the necrotic tissue and the sequestrum. Thereafter, the patient was able to walk with the help of a patellar tendon-bearing (PTB) orthosis and was discharged from the hospital. Walking on a prosthetic leg is often difficult for elderly patients. Therefore, we suggest using a PTB orthosis to avoid major amputation and to facilitate rehabilitation in elderly patients with diabetic gangrene.

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