SapienzaUniversity of Rome

Rome, Italy

SapienzaUniversity of Rome

Rome, Italy
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Rossini F.L.,SapienzaUniversity of Rome | Novembri G.,SapienzaUniversity of Rome | Fioravanti A.,SapienzaUniversity of Rome | Insola C.,SapienzaUniversity of Rome
eWork and eBusiness in Architecture, Engineering and Construction - Proceedings of the 11th European Conference on Product and Process Modelling, ECPPM 2016 | Year: 2016

The need to manage complexity, and the current necessity of interventions on existing buildings to provide project and construction methodologies and tools capable to support them in a proficient way. With the scope to define in advance the places occupied by workers to accomplish a task, is defined a methodology and a related tool to integrate Building Information Modeling (BIM) with an Agent-Based simulation of workers. The goal is to know as early as possible: where it is possible to work in a productive and safe way; how it is possible to be more efficient placing in the same working space different working phases; when it is possible to allow the continuity of building operations. © 2016 Taylor & Francis Group.

PubMed | University of Rome La Sapienza, Medicina Interna, SapienzaUniversity of Rome, RiUniti Hospital and San Pietro Fatebenefratelli Hospital
Type: Journal Article | Journal: Internal and emergency medicine | Year: 2016

Vitamin D deficiency has been reported in patients with chronic inflammatory conditions, such as rheumatic and inflammatory bowel diseases (IBD). We evaluated the role of biologic therapy on vitamin D, calcium and parathormone (PTH) levels. This cross-sectional study enrolled consecutive patients with either rheumatic diseases or IBD who underwent an ambulatory visit. Patients receiving vitamin D/calcium supplementation were excluded. Vitamin D deficiency or insufficiency was diagnosed when values were <20ng/mL and 21-29ng/ml, respectively. Patients were sub-grouped according to biologic therapy. A multivariate analysis was performed. Two-hundred patients, including 136 with a rheumatic disease (M/F 37/99; mean age 60.712.9years) and 64 with IBD (M/F 41/23; Mean age 49.613.1years) were enrolled. Vitamin D deficiency/insufficiency was detected in as many as 63.5% patients, being 61.8 and 67.2% in patients with either rheumatic diseases or IBD, respectively. The prevalence of vitamin D deficiency/insufficiency was higher in those receiving biologics than other therapies (78.3 vs 43.2%; p<0.0001), in either rheumatic diseases (78.7 vs 41%; p<0.0001) or IBD (75 vs 50%; p=0.03) group. At multivariate analysis, only biologic therapy was independently associated with vitamin D deficit (OR 4.61; p=0.001). Patients with vitamin D deficiency/insufficiency had hypocalcemia more frequently than controls (22.8 vs 10.9%; p=0.03), while PTH values did not differ significantly. This study finds that the prevalence of vitamin D deficiency/insufficiency was very high in patients with either rheumatic diseases or IBD receiving a biologic therapy.

PubMed | A. Cardarelli Company Hospital, CNR Institute of Neuroscience, The Second University of Naples, University of Naples Federico II and 5 more.
Type: Journal Article | Journal: Journal of prenatal medicine | Year: 2015

the purpose of this paper is to report the first case of megaurethra in a fetus with Meckel syndrome and in a fetus with femal pseudoermaphroditism.the former case refers to a fetus of 13 weeks gestation with the three following prominent anomalies, observed by transonic scan and confirmed by autopsy: congenital megaurethra, anal atresia, single umbelical artery. The latter case refers to a fetus of 18 weeks gestation. Autopsy confirmed penile malformation and revealed ovaries in the abdomen. The karyotype was 46,XX with normal molecular karytype. The megaurethra was discovered by sonography at 18 weeks gestation. Autopsy confirmed penile malformation and revealed ovaries in the abdomen. The karyotype was 46,XX with normal molecular karyotype (Array-CGH, 1 Mb of resolution).transonic scan, autopsy, karyotype, array-CGH.the first prenatal cases of two genetic syndromes with megaurethra have been reported, concening respectively a fetus with Meckel syndrome and a fetus with femal pseudoermaphroditism. The latter was confirmed by both autopsy and the normal female 46,XX karyotype.

Da Pozzo A.,SapienzaUniversity of Rome | Petrucci E.,SapienzaUniversity of Rome
Desalination and Water Treatment | Year: 2015

Abstract: The efficiency of both chemical and electrochemical Fenton processes to treat wastewater effluents from the manufacture of phosphorus-based flame retardants was investigated. Experimental tests were performed on solutions ranging from 600 to 2000 mg l−1 in terms of reduced phosphorus. Different concentrations and ratios of hydrogen peroxide and ferrous ions were tested, and the best conditions were found for both the processes. For the electrochemical treatment, where a gas diffusion cathode was adopted, the effect of carbon coating and current density was investigated, identifying the hydrophilic carbon coating, named Vulcan, as the best cathode material and the value of 100 A m−2 as the optimal current density. The results show that both the Fenton processes provide a powerful conversion to phosphate, with oxidation yields higher than 99%. However, a more cost-friendly sequential treatment, combining a preliminary chemical step to a final electro-oxidation, was proposed to reach a residual concentration of non-oxidized phosphorus less than 10 mg l−1, in compliance with the Italian regulation limits for industrial wastewater disposal. A preliminary economic evaluation is provided. © 2013 Balaban Desalination Publications. All rights reserved.

Internullo M.,SapienzaUniversity of Rome | Giannelli V.,University of Rome La Sapienza | Sardo L.,SapienzaUniversity of Rome | Antonaglia C.,SapienzaUniversity of Rome | And 3 more authors.
European Review for Medical and Pharmacological Sciences | Year: 2014

Hydroxyurea is a cytotoxic agent widely used in the treatment of myeloproliferative disorders. It is considered a-well-tolerated antineoplastic drug, with a dose-related bone marrow suppression as main adverse effect. This report describes a patient with essential thrombocythemia who developed an interstitial pneumonitis and respiratory failure within 4 years from beginning therapy with hydroxyurea (HU). After discontinuing of HU. both clinical and radiological resolution of pneumonitis occurred. In conclusion, HU-induced pulmonary toxicity is a potentially life-threatening side effect.

Bianchini C.,SapienzaUniversity of Rome | Borgogni F.,SapienzaUniversity of Rome | Ippolito A.,SapienzaUniversity of Rome | Senatore L.J.,SapienzaUniversity of Rome
Lecture Notes in Computational Vision and Biomechanics | Year: 2014

The study and analysis of archaeological elements often swings from large sites to small objects. This variability in dimensions and typology actually determines an equal variability of problems encountered during the surveying and representation process so that it is hard to retrieve a reliable common theoretical and operational background able to guide the researcher through the various steps. The problems connected with the interpretation of data (and their lack of clarity) disturb in fact considerably the final goal of surveying: achieve the most profound knowledge of the object analyzed. Taking into consideration numerous survey campaigns carried out for years, this chapter seeks to present a modus operandi that seems to be indispensable for standardizing and regulating procedures of data collecting, elaborating and representing applied by our research team from theDepartment of History, Drawing and Restoration of Architecture (Sapienza—University of Rome), the aim being to make the final result scientific, i.e. more objective and correct. Together with a general methodological framing, we shall describe a number of researchprojects spanning from large sites (Petra), single buildings/architectural structures (The Temple of Divus Claudio, Rome) and small objects (Tombs and artifacts in Crustumerium – Rome). © Springer International Publishing Switzerland 2014.

Farcomeni A.,SapienzaUniversity of Rome
Statistics and Computing | Year: 2014

We introduce the concept of snipping, complementing that of trimming, in robust cluster analysis. An observation is snipped when some of its dimensions are discarded, but the remaining are used for clustering and estimation. Snipped k-means is performed through a probabilistic optimization algorithm which is guaranteed to converge to the global optimum. We show global robustness properties of our snipped k-means procedure. Simulations and a real data application to optical recognition of handwritten digits are used to illustrate and compare the approach. © 2013, Springer Science+Business Media New York.

Gatta F.M.,SapienzaUniversity of Rome | Geri A.,SapienzaUniversity of Rome | Lauria S.,SapienzaUniversity of Rome | Maccioni M.,SapienzaUniversity of Rome
Electric Power Systems Research | Year: 2014

Simulation of direct lightning strokes to overhead line towers requires accurate modeling of tower grounding systems. When large-scale statistical simulations are needed (e.g. in backflashover rate assessment), detailed but computationally intensive models are not suitable. This paper presents a genetic algorithm-based procedure to synthesize a generalized pi-circuit model, aimed at simulating the impulse response of complex grounding systems, including non-linear soil ionization, for backflashover studies. The equivalent electrical parameters of the pi-circuit model are determined as functions of soil resistivity for some commonly used grounding systems; the pi-circuit model is then validated by time-domain ATP-EMTP comparison with a complete circuit model, obtaining very good results (worst-case errors do not exceed 3-4%). ATP-EMTP time-domain simulations of direct lightning strokes to overhead lines equipped with the pi-circuit model are also reported, showing an excellent agreement with results yielded by the complete circuit model as well as drastically decreased computation times (up to 3 orders of magnitude). © 2014 Elsevier B.V.

Pastori D.,University of Rome La Sapienza | Esposito A.,SapienzaUniversity of Rome | Mezzaroma I.,SapienzaUniversity of Rome
International Reviews of Immunology | Year: 2011

Intravenous immunoglobulins (IVIGs) are generally used as replacement therapy for humoral immunodeficiencies. In consideration of their immune-modulating properties, they are also employed as "immune-modulating/ anti-inflammatory" treatment in different clinical conditions. In HIV-1 infection, an increased incidence of autoimmune and auto-inflammatory manifestations has been described, probably as a consequence of the chronic immune activation associated with the disease. The initial use in the treatment of bacterial infections in children with HIV/AIDS has been replaced by the treatment, in combination with antiretroviral therapy, of these autoimmune/inflammatory conditions. We review the results obtained with IVIGs therapy in these HIV-1-associated clinical manifestations. © 2011 Informa Healthcare USA, Inc.

PubMed | SapienzaUniversity of Rome
Type: | Journal: Journal of neurosurgical sciences | Year: 2015

To evaluate the results of surgery for vertebral involvement in MM following the introduction of the new chemotherapy in 2006.Retrospective cohort study evaluating the patients with MM vertebral lesions from January 2006 to January 2014. Outcomes were based upon participation in ODI and EQ-5D. Statistical interpretation of the data was performed with SPSS version 19 software (SPSS Inc, Chicago, Illinois).120 patients affected by MM were potentially eligible for recruitment. About 1/3 patients needed an operation for vertebral involvement. The disability was mainly related to the number of vertebrae affected by MM. No difference in disability and quality of life was observed between operated and non-operated patients, according to age, levels, and follow-up. The operated patients with a Thoracic location reported lower disability and higher quality of life than non-operated patients. Non-operated patients with one or two vertebrae affected reported lower levels of quality of life.When a spinal column involvement occurs, the probability of undergoing surgery is about 40%. Operated patients show a moderate disability and the increased tendency is related to the number of vertebrae involved. The quality of life is middle in average and middle-high in patients operated for thoracic lesions. Nowadays the spinal surgeon must have a perspective view about MM vertebral lesions, evaluating the stability of the spine, the presence of deformity, the risk of vertebral fractures and the presence of drug resistant pain, that deteriorate the disability and the quality of life related to the underlying disease.

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