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Farcomeni A.,SapienzaUniversity of Rome
Statistics and Computing

We introduce the concept of snipping, complementing that of trimming, in robust cluster analysis. An observation is snipped when some of its dimensions are discarded, but the remaining are used for clustering and estimation. Snipped k-means is performed through a probabilistic optimization algorithm which is guaranteed to converge to the global optimum. We show global robustness properties of our snipped k-means procedure. Simulations and a real data application to optical recognition of handwritten digits are used to illustrate and compare the approach. © 2013, Springer Science+Business Media New York. Source

Stefanutti C.,SapienzaUniversity of Rome | D'Alessandri G.,Immunohematology and Transfusion Medicine | Petta A.,Kaneka Pharma Europe NV | Harada-Shiba M.,Japan National Cardiovascular Center Research Institute | And 26 more authors.
Atherosclerosis Supplements

The MightyMedic (Multidisciplinary International Group for Hemapheresis TherapY and MEtabolic DIsturbances Contrast) Working Group has been founded in 2013. The leading idea was to establish an international network of interdisciplinary nature aimed at working to cross national borders research projects, clinical trials, educational initiatives (meetings, workshops, summer schools) in the field of metabolic diseases, namely hyperlipidemias, and diabetes, preventive cardiology, and atherosclerosis. Therapeutic apheresis, its indications and techniques, is a parallel field of investigation. The first on-line survey of the Group has been completed in the first half of 2014. The survey included # 24 Centers in Italy, Germany, Greece, UK, Sweden, Japan and USA. Relevant data have been collected on current practice in diagnosis, therapy and follow-up of dyslipidemias. 240 subjects with hyperlipidemia and treated with lipoprotein apheresis have been reported in the survey, but a large percentage of patients (35%) who could benefit from this therapeutic option are still treated by conventional drug approach. Genetic molecular diagnosis is performed in only 33% of patients while Lipoprotein(a) (Lp(a)) is included in cardiovascular disease risk assessment in 71% of participating Centers. New detailed investigations and prospective multicenter studies are needed to evaluate changes induced by the impact of updated indications and strategies, as well as new treatment options, targeting standardization of therapeutic and diagnostic approaches. © 2015 Elsevier Ireland Ltd. Source

Bruzzese V.,Medicina Interna | Zullo A.,Medicina Interna | Piacchianti Diamanti A.,SapienzaUniversity of Rome | Ridola L.,University of Rome La Sapienza | And 7 more authors.
Internal and Emergency Medicine

Vitamin D deficiency has been reported in patients with chronic inflammatory conditions, such as rheumatic and inflammatory bowel diseases (IBD). We evaluated the role of biologic therapy on vitamin D, calcium and parathormone (PTH) levels. This cross-sectional study enrolled consecutive patients with either rheumatic diseases or IBD who underwent an ambulatory visit. Patients receiving vitamin D/calcium supplementation were excluded. Vitamin D deficiency or insufficiency was diagnosed when values were <20 ng/mL and 21–29 ng/ml, respectively. Patients were sub-grouped according to biologic therapy. A multivariate analysis was performed. Two-hundred patients, including 136 with a rheumatic disease (M/F 37/99; mean age 60.7 ± 12.9 years) and 64 with IBD (M/F 41/23; Mean age 49.6 ± 13.1 years) were enrolled. Vitamin D deficiency/insufficiency was detected in as many as 63.5 % patients, being 61.8 and 67.2 % in patients with either rheumatic diseases or IBD, respectively. The prevalence of vitamin D deficiency/insufficiency was higher in those receiving biologics than other therapies (78.3 vs 43.2 %; p < 0.0001), in either rheumatic diseases (78.7 vs 41 %; p < 0.0001) or IBD (75 vs 50 %; p = 0.03) group. At multivariate analysis, only biologic therapy was independently associated with vitamin D deficit (OR 4.61; p = 0.001). Patients with vitamin D deficiency/insufficiency had hypocalcemia more frequently than controls (22.8 vs 10.9 %; p = 0.03), while PTH values did not differ significantly. This study finds that the prevalence of vitamin D deficiency/insufficiency was very high in patients with either rheumatic diseases or IBD receiving a biologic therapy. © 2016 SIMI Source

Da Pozzo A.,SapienzaUniversity of Rome | Petrucci E.,SapienzaUniversity of Rome
Desalination and Water Treatment

Abstract: The efficiency of both chemical and electrochemical Fenton processes to treat wastewater effluents from the manufacture of phosphorus-based flame retardants was investigated. Experimental tests were performed on solutions ranging from 600 to 2000 mg l−1 in terms of reduced phosphorus. Different concentrations and ratios of hydrogen peroxide and ferrous ions were tested, and the best conditions were found for both the processes. For the electrochemical treatment, where a gas diffusion cathode was adopted, the effect of carbon coating and current density was investigated, identifying the hydrophilic carbon coating, named Vulcan, as the best cathode material and the value of 100 A m−2 as the optimal current density. The results show that both the Fenton processes provide a powerful conversion to phosphate, with oxidation yields higher than 99%. However, a more cost-friendly sequential treatment, combining a preliminary chemical step to a final electro-oxidation, was proposed to reach a residual concentration of non-oxidized phosphorus less than 10 mg l−1, in compliance with the Italian regulation limits for industrial wastewater disposal. A preliminary economic evaluation is provided. © 2013 Balaban Desalination Publications. All rights reserved. Source

Pastori D.,University of Rome La Sapienza | Esposito A.,SapienzaUniversity of Rome | Mezzaroma I.,SapienzaUniversity of Rome
International Reviews of Immunology

Intravenous immunoglobulins (IVIGs) are generally used as replacement therapy for humoral immunodeficiencies. In consideration of their immune-modulating properties, they are also employed as "immune-modulating/ anti-inflammatory" treatment in different clinical conditions. In HIV-1 infection, an increased incidence of autoimmune and auto-inflammatory manifestations has been described, probably as a consequence of the chronic immune activation associated with the disease. The initial use in the treatment of bacterial infections in children with HIV/AIDS has been replaced by the treatment, in combination with antiretroviral therapy, of these autoimmune/inflammatory conditions. We review the results obtained with IVIGs therapy in these HIV-1-associated clinical manifestations. © 2011 Informa Healthcare USA, Inc. Source

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