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Figueira R.D.C.S.,Fertility Assisted Fertilization Center | De Almeida Ferreira Braga D.P.,Sapientiae Institute Educational | Semiao-Francisco L.,Fertility Assisted Fertilization Center | Madaschi C.,Fertility Assisted Fertilization Center | And 4 more authors.
Fertility and Sterility | Year: 2010

Morphologic abnormalities in the oocyte are relevant for determining its developmental fate and could be related to controlled ovarian stimulation protocols and ovarian response. The contributing factors of oocyte dysmorphism incidence and its effects on fertilization potential and embryo development are the object of discussion in this study. © 2010 by American Society for Reproductive Medicine. Source


De Almeida Ferreira Braga D.P.,Fertility Assisted Fertilization Center | De Almeida Ferreira Braga D.P.,Sapientiae Institute Educational | Setti A.S.,Sapientiae Institute Educational | De Cassia S. Figueira R.,Fertility Assisted Fertilization Center | And 4 more authors.
Journal of Assisted Reproduction and Genetics | Year: 2012

Purpose: To evaluate different factors that might affect the incidence of embryo aneuploidy in intracytoplasmic sperm injection cycles (ICSI). Methods: One hundred and ninety ICSI cycles in conjunction with preimplantation genetic screening (PGS) were included. The influence of the following variables on the aneuploidy incidence was evaluated: (i) maternal and (ii) paternal ages, (iii) dose of FSH administered, (iv) dose of FSH per number of retrieved matured oocytes (FSH/MII), (v) serum 17â-oestradiol levels on the ovulation trigger day, (vi) aspirated follicles and (vii) retrieved oocytes. Results: A total of 440 embryos were successfully biopsied, of which 240 were considered euploid and 200 were considered aneuploid. The paternal age (Slope: 0.2, p00.372), total dose of FSH (Slope: 0.2, p00.218), FSH/MII (Slope: 0.1, p00.296) and 17â-oestradiol levels (Slope: 0.2, p0 0.378) were not correlated with the presence of aneuploidy. However, the maternal age (Slope: 1.7, p<0.01), aspirated follicles (Slope: 1.9, p<0.01) and retrieved oocytes (Slope: 2.6, p<0.01) were negatively correlated with the incidence of aneuploidy. Conclusions: Even in older patients, lower oocyte yields may represent a more appropriate response to ovarian stimulation, allowing the most competent follicles and oocytes to develop and thereby reducing the occurrence of embryo aneuploidy. © Springer Science+Business Media, LLC 2012. Source


Setti A.S.,Sapientiae Institute Educational | Figueira R.C.S.,Fertility Assisted Fertilisation Center | Braga D.P.A.F.,Sapientiae Institute Educational | Braga D.P.A.F.,Fertility Assisted Fertilisation Center | And 4 more authors.
Reproductive BioMedicine Online | Year: 2012

The aim of this prospective randomized study was to determine if the use of intracytoplasmic morphologically selected sperm injection (IMSI) is associated with gender incidence. Couples who underwent IVF-preimplantation genetic screening (PGS) cycles, as a result of advanced maternal age, were randomly allocated into two groups: intracytoplasmic sperm injection (ICSI; n = 80) or intracytoplasmic morphologically selected sperm injection (IMSI; n = 80). The incidences of genders were compared between ICSI- and IMSI-derived embryos. Considering all the biopsied embryos were characterized as normal for sex chromosome, the results showed that IMSI results in a significantly higher incidence of female embryos as compared with ICSI (65.1% versus 54.0%, respectively, P = 0.0277). After analysing only euploid embryos for the eight selected chromosomes, a significantly higher incidence of XX embryos derived from IMSI was also observed compared with ICSI cycles (66.9% versus 52.5%, respectively, P = 0.0322). This result was confirmed by logistic regression, which demonstrated a nearly 2-fold increase in euploid XX embryos derived from spermatozoa selected by high magnification (OR 1.83, 95% CI 1.05-3.35, P = 0.032). A higher proportion of morphologically normal spermatozoa analysed under high magnification seem to carry the X chromosome. The aim of this study was to determine if the use of intracytoplasmic morphologically selected sperm injection (IMSI) is associated with gender incidence. Couples who underwent IVF with preimplantation genetic screening, as a result of advanced maternal age, were randomly allocated into two groups: intracytoplasmic sperm injection (ICSI; n = 80) or intracytoplasmic morphologically selected sperm injection (IMSI; n = 80). The incidences of genders were compared between ICSI- and IMSI-derived embryos. Our results showed that a significantly higher incidence of female embryos derived from IMSI compared with ICSI cycles (66.9% versus 52.5%, respectively, P = 0.0322). This result was confirmed by logistic regression, which demonstrated a nearly 2-fold increase in female embryos derived from sperm selected by high magnification (OR 1.83, 95% CI 1.05-3.35, P = 0.032). A higher proportion of morphologically normal spermatozoa analysed under high magnification seem to carry the X chromosome. © 2012, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved. Source

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