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Newtown Square, PA, United States

SAP SE is a German multinational software corporation that makes enterprise software to manage business operations and customer relations. SAP is headquartered in Walldorf, Baden-Württemberg, Germany, with regional offices in 130 countries. Wikipedia.

Biofilm-related infections caused by Candida albicans and associated drug resistant micro-organisms are serious problems for immunocompromised populations. Molecules which can prevent or remove biofilms are needed. Twenty-eight terpenoids of plant origin were analysed for their activity against growth, virulence attributes, and biofilms of C. albicans. Eighteen molecules exhibited minimum inhibitory concentrations of <2 mg ml(-1) for planktonic growth. Selected molecules inhibited yeast to hyphal dimorphism at low concentrations (0.031-0.5 mg ml(-1)), while adhesion to a solid surface was prevented at 0.5-2 mg ml(-1). Treatment with 14 terpenoids resulted in significant (p < 0.05) inhibition of biofilm formation, and of these, linalool, nerol, isopulegol, menthol, carvone, α-thujone, and farnesol exhibited biofilm-specific activity. Eight terpenoids were identified as inhibitors of mature biofilms. This study demonstrated the antibiofilm potential of terpenoids, which need to be further explored as therapeutic strategy against biofilm associated infections of C. albicans.

Kilbinger M.,SAP
Reports on Progress in Physics | Year: 2015

Cosmic shear is the distortion of images of distant galaxies due to weak gravitational lensing by the large-scale structure in the Universe. Such images are coherently deformed by the tidal field of matter inhomogeneities along the line of sight. By measuring galaxy shape correlations, we can study the properties and evolution of structure on large scales as well as the geometry of the Universe. Thus, cosmic shear has become a powerful probe into the nature of dark matter and the origin of the current accelerated expansion of the Universe. Over the last years, cosmic shear has evolved into a reliable and robust cosmological probe, providing measurements of the expansion history of the Universe and the growth of its structure. We review here the principles of weak gravitational lensing and show how cosmic shear is interpreted in a cosmological context. Then we give an overview of weak-lensing measurements, and present the main observational cosmic-shear results since it was discovered 15 years ago, as well as the implications for cosmology. We then conclude with an outlook on the various future surveys and missions, for which cosmic shear is one of the main science drivers, and discuss promising new weak cosmological lensing techniques for future observations. © 2015 IOP Publishing Ltd.

Agency: Cordis | Branch: H2020 | Program: IA | Phase: LCE-03-2015 | Award Amount: 17.11M | Year: 2016

In ELICAN, a strong team of complementary European companies with worldwide leading presence in the Wind Energy industry join forces to provide the market with a disruptive high-capacity and cost-reducing integrated substructure system for deep offshore wind energy. The technology is exceptionally fitted to meet the technical and logistical challenges of the sector as it moves into deeper locations with larger turbines, while allowing for drastic cost reduction. This project will design, build, certify and fully demonstrate in operative environment a deep water substructure prototype supporting Adwens 5MW offshore wind turbine, the be installed in the Southeast coast of Las Palmas (Canary Islands). It will become the first bottom-fixed offshore wind turbine in all of Southern Europe and the first one worldwide to be installed with no need of heavy-lift vessels. The revolutionary substructure consists in an integrated self-installing precast concrete telescopic tower and foundation that will allow for crane-free offshore installation of the complete substructure and wind turbine, thus overcoming the constraints imposed by the dependence on heavy-lift vessels. It will allow for a full inshore preassembly of the complete system, which is key to generate a highly industrialized low-cost manufacturing process with fast production rates and optimized risk control. The main benefits to be provided by this ground-breaking technology are: Significant cost reduction (>35%) compared with current solutions. Direct scalability in terms of turbine size, water depth, infrastructure and installation means. Complete independence of heavy-lift vessels Excellently suited for fast industrialized construction. Robust and durable concrete substructure for reduced OPEX costs and improved asset integrity. Suitable for most soil conditions, including rocky seabeds. Enhanced environmental friendliness regarding both impact on sea life and carbon footprint.

Agency: Cordis | Branch: H2020 | Program: RIA | Phase: ICT-16-2015 | Award Amount: 6.31M | Year: 2016

The TOREADOR project is aimed at overcoming some major hurdles that until now have prevented many European companies from reaping the full benefits of Big Data analytics (BDA). Companies and organisations in Europe have become aware of the potential competitive advantage they could get by timely and accurate Big Data analytics, but lack the IT expertise and budget to fully exploit BDA. To overcome this hurdle, TOREADOR takes a model-based BDA-as-a-service (MBDAaaS) approach, providing models of the entire Big Data analysis process and of its artefacts. TOREADOR open, suitable-for-standardisation models will support substantial automation and commoditisation of Big Data analytics, while enabling it to be easily tailored to domain-specific customer requirements. Besides models for representing BDA, TOREADOR will deliver an architectural framework and a set of components for model-driven set-up and management of Big Data analytics processes. Once TOREADOR MBDAaaS will become widespread, price competition on Big Data services will ensue, driving costs of Big Data analytics well within reach of EU organizations (including SMEs) that do not have either in-house Big Data expertise or budget for expensive data consultancy. Activities supported and automatised by TOREADOR will include (i) planning Big Data sources preparation (ii) negotiating machine-readable Service Level Agreements for BDA detailing privacy, timing, and accuracy needs (iii) choosing data management and algorithm parallelisation strategies (iv) ensuring auditing and assessment of legal compliance (for example, to privacy regulations) of BDA enactment. TOREADOR framework will address automatically all major problems of on-demand data preparation, including handling Big Data opacity, diversity, security, and privacy compliance, and will support abstract modelling of the BDA life cycle from distributed data acquisition/storage to the design and parallel deployment of analytics and presentation of results.

Agency: Cordis | Branch: H2020 | Program: RIA | Phase: LCE-06-2015 | Award Amount: 12.99M | Year: 2016

Four European TSOs of Central-Eastern Europe (Austria, Hungary, Romania, Slovenia), associated with power system experts, electricity retailers, IT providers and renewable electricity providers, propose to design a unique regional cooperation scheme: it aims at opening Balancing and Redispatching markets to new sources of flexibility and supporting such sources to act on such markets competitively. Thanks to a prototype aggregation solution and renewable generation forecasting techniques, flexibility providers distributed generators (DG) and Commercial and Industrial (C&I) consumers providing demand response (DR) are enabled, through retailers acting as flexibility aggregators, to provide competitive offers for Frequency Restoration Reserve (including secondary control activated with a response time between 30 seconds and 15 minutes). A comprehensive techno-economic model for the cross-border integration of such services involves a common activation function (CAF) tailored to congested borders and optimized to overcome critical intra-regional barriers. The resulting CAF is implemented into a prototype Regional Balancing and Redispatching Platform, securely integrated within the four TSOs IT systems: this makes research activities about cross-border integration flexible while linking with the aggregation solution. Use cases of growing complexity are pilot tested, going from the involvement of DR and DG into national balancing markets to cross-border competition between flexibility aggregators. Based on past experience with tertiary reserve, participating C&I consumers and DG are expected to provide close to 40MW of secondary reserve. Impact analyses of the pilot tests together with dissemination activities towards all the stakeholders of the electricity value chain will recommend business models and deployment roadmaps for the most promising use cases, which, in turn, contribute to the practical implementation of the European Balancing Target Model by 2020.

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