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Ghāziābād, India

Suhail N.,iversity | Bilal N.,iversity | Khan H.Y.,iversity | Hasan S.,iversity | And 4 more authors.
Journal of Clinical Pharmacy and Therapeutics | Year: 2012

What is known and Objective: Reactive oxygen/nitrogen species generated by antineoplastic agents are prime suspects for the toxic side-effects of acute or chronic chemotherapy. The present study was undertaken to test whether vitamins C and E (VCE) supplementation protect against some of the harmful effects of commonly used anticancer drugs in breast-cancer patients. Methods: In a randomized 5-month study, the activity of various antioxidant enzymes (superoxide dismutase, catalase, glutathione-S-transferase and glutathione reductase) and the levels of malondialdehyde and reduced glutathione were measured in forty untreated breast-cancer patients (stage II) and compared with those of healthy controls. The degree of DNA damage was also assessed in the peripheral lymphocytes of the patients by alkaline single cell gel electrophoresis. The untreated patients were then randomly assigned to either treatment with chemotherapy alone (5-fluorouracil 500 mg/m 2 i.v. day 1, doxorubicin 50 mg/m 2 i.v. day 1 and cyclophosphamide 500 mg/m 2 i.v. day 1, every 3 weeks for six cycles) or to the same chemotherapy regimen supplemented with VCE (vitamin C 500 mg tablet and vitamin E 400 mg gelatin capsule). On completion of the treatments, both the groups were studied again for the levels of the markers measured prior to treatment. Results and Discussion: The untreated group showed significantly lower levels of antioxidant enzymes (P < 0·001) and reduced glutathione (P < 0·001), and more extensive lipid peroxidation (P < 0·001) and DNA damage than healthy controls. Similar but less pronounced patterns were observed in the patients receiving chemotherapy alone. The group of patients receiving VCE supplementation had all the marker levels moving towards normal values. Activities of superoxide dismutase, catalase, glutathione-S-transferase and glutathione reductase, and the levels of reduced glutathione were significantly increased (P < 0·01) while, the levels of malondialdehyde and DNA damage were significantly (P < 0·01) reduced in the VCE supplemented group relative to those of patients receiving chemotherapy alone as well as relative to the pretreatment levels. What is new and Conclusion: Co-administration of VCE restored antioxidant status, lowered by the presence of breast-cancer and chemotherapy. DNA damage was also reduced by VCE. The results suggest that VCE should be useful in protecting against chemotherapy-related side-effects and a randomized control trial to evaluate the effectiveness of VCE in breast-cancer patients using clinical outcomes would be appropriate. © 2011 Blackwell Publishing Ltd.


Kharb P.,Sharda University | Samanta P.P.,Sharda University | Jindal M.,Sharda University | Singh V.,Santosh University
Journal of Clinical and Diagnostic Research | Year: 2013

Introduction: The purpose of teaching is to facilitate learning and to encourage the learners to learn more effectively. The learning style is an individual's consistent way of perceiving, pro-cessing and retaining new information. Educational researchers have shown an increasing interest in the learning styles, the re-lated instructional methods and the andrgogical teaching tech-niques. This interest is spurred by a desire to help the students to become capable and successful learners. Aim: The aim of this study was to determine the preferred learning styles of medical students as well as their preferences of specific teaching-learning methods. Method: A cross sectional study was conducted on 100 first semester medical students who were enrolled at SMS & R, Sharda University, India. The VARK questionnaire, version 7.1 was used to categorize the learning preferences/modes as visual (V), auditory (A), read and write (R) and kinaesthetic (K). The students were also asked to rank the various teach-ing methodologies viz. lectures, tutorials, demonstrations and practicals/dissections from the most preferred choice to the least preferred one. Results: The majority (61%) of the students had multimodal VARK preferences. Among them, 41%, 14% and 6% preferred the bimodal, trimodal and the quadrimodal ways of informa-tion presentation. 39% of the respondents had one strong (unimodal) learning preference. The most common unimodal preference was kinaesthetic, followed by visual, auditory and read and write. The most preferred teaching methodology was practical/dissection (39%) and tutorial was the least preferred one (12%). Conclusion: One single approach to teaching does not work for every student or even for most of the students. The educa-tors' awareness of the various learning styles of the students and their efforts towards matching the teaching and learning styles may help in creating an effective learning environment for all the students.


Gupta S.,Venkateshwara Institute of Medical science | Gupta R.,Venkateshwara Institute of Medical science | Gupta G.,Santosh University | Gupta K.,Birla Institute of Technology and Science
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2015

Diabetes mellitus is most frequently occurring metabolic disorder. ABO blood group was found to be associated with various disorders. An association between ABO blood group and type 2 diabetes mellitus has been observed in various studies, but conflicting results were obtained.1122 known diabetic patients, both male and female were enrolled for the study. ABO blood group, random blood sugar and body mass index were measured. Slide agglutination method was performed for measuring the ABO blood group. Obesity was measured by body mass index, which was obtained by dividing the weight of an individual by the square of height. Significant results (<0.05) were obtained between male and female population among the various blood groups. There was a significant difference (<0.05) between the obese and non obese persons of type 2 diabetes mellitus. The highest percentage of diabetic patients was observed in B blood group followed by O blood group in both male and female. Among the entire study population approximately 38% patients were having B blood group. Patients having AB blood group were lowest in the entire study population.


Sharma P.,Santosh University | Kumar P.,Santosh University
Asian Journal of Pharmaceutical and Clinical Research | Year: 2016

For thousands of years, yoga an ancient holistic relaxation practice has been used as an effective therapeutic tool that counteracts the adverse clinical conditions of human beings. A host of bodily changes has been observed under the influence of yoga. Such practices are really helpful in numerous disorders including hypertension, obesity, anxiety, insomnia and aging itself and a number of other disorders. However, the underlying molecular mechanisms that explain these clinical benefits are still an enigma. The efficacy of yoga and meditation as an adjunct to routine management of various diseases and disorder is a great challenge in the present scenario. Ayurvedic knowledge of yoga is much more incompatible with its understanding of biochemical and hematological changes. Exploring the biochemical association with various yogic postures and practices will definitely improve the practice as therapeutic adjuvant and thus, will improve the quality of life. © 2016, Asian Journal of Pharmaceutical and Clinical Research. All rights reserved.


Sharma R.,TSM Medical College and Hospital | Sharma P.,Santosh University | Kumar P.,Santosh University | Gupta G.,Santosh University
Asian Journal of Pharmaceutical and Clinical Research | Year: 2016

Objective: Osteoporosis is quite common in elderly people, especially in post-menopausal women. The role of Magnesium, an impOrtant cation along with calcium for bone formation, is not very well-studied in osteoporosis as well as osteopenia group. Methods: Total 68 post-menopausal women 48-75 years of age group, were included in this study. In which, 33 women were having osteoporosis while rest 35 were from osteopenia. The differentiation between osteoporosis and osteopenia were done with the bone mineral density usually expressed in T score and Z score. Serum total calcium, ionized calcium, serum phosphate, serum alkaline phosphatase, and serum magnesium were estimated in post-menopausal women. Results: Significant results were obtained in various parameters. In osteopenic women, the mean values of total calcium (8.25±1.25 vs. 9.29±0.62) and ionized calcium (4.22±0.51 vs. 4.64±0.31) were significantly (<0.001) higher. The serum concentration of alkaline phosphatase (159.87±37.11 vs. 137.21±33.29) was significantly higher (<0.01) in osteoporosis group. The serum concentration of magnesium (1.95±0.44 vs. 2.22±0.42) was lower in osteoporosis group, and the result was statistically significant (<0.05). Conclusion: In post-menopausal women, osteoporosis is characterized by a lower concentration of magnesium. Hypomagnesemia may result in inflammatory disorders which have an existing relationship with bone loss. The dietary intake of magnesium supplement may be useful in reducing the adverse effect of osteoporosis. © 2016, Asian Journal of Pharmaceutical and Clinical Research. All rights reserved.

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