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Shrestha S.,Hind Institute of Medical science | Sharma P.,Santosh Medical College & Hospital Santosh University | Kumar P.,Santosh Medical College & Hospital Santosh University | Saxena S.P.,Hind Institute of Medical science | Sharma R.,TSM Medical College and Hospital
Asian Journal of Pharmaceutical and Clinical Research | Year: 2017

Among the adipokines, adiponectin is the first one to be described just over a decade ago. It is produced exclusively by adipose tissue and circulates in high concentration in human plasma accounting for 0.01% of proteins in plasma, almost thousand times higher than that of leptin. The normal circulating level of adiponectin ranges from 2 to 30 µg/ml. It is now observed that besides adipose tissue, adiponectin can also be produced by several other tissues such as hepatocytes, cardiomyocytes, and placenta. Adiponectin executes its action via autocrine as well as and paracrine effects. Researchers working in this area have revealed that adiponectin has insulin-sensitizing, anti-inflammatory and cardioprotective effects. Our review focuses on adiponectin, its mode of action on different peripheral tissues such as skeletal muscles, heart, liver, brain and its the correlative account in various diseases. © 2017 The Authors.


Sharma P.,Santosh Medical College & Hospital Santosh University | Kumar P.,Santosh Medical College & Hospital Santosh University | Sharma R.,TSM Medical College & Hospital | Dhot P.S.,Santosh Medical College & Hospital Santosh University
Asian Journal of Pharmaceutical and Clinical Research | Year: 2016

The most potential application of the stem cells (SCs) in human beings lies in their ability to regenerate cells and tissues. They differentiate themselves into specific cell type, thereby availing remarkable source of replacement cells and tissues. They differentiate themselves into specific cell types, thereby availing renewable source of replacement cells and tissues. Their potential of regeneration has now opened many avenues in the field of medical science and research. As a therapeutic adjuvant in near future, the SCs will emerge as an efficient technique to completely heal a number of diseases including diabetes, heart diseases and strokes, osteoarthritis, rheumatoid arthritis, and macular degeneration. The researches, which are underway, some of them will surely be proved as safe and effective SC treatment in the market in due course of time. © 2016, Innovare Academics Sciences Pvt. Ltd. All rights reserved.

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