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Hochhegger B.,Santa Casa de Porto Alegre | Hochhegger B.,Federal University of Rio de Janeiro | Marchiori E.,Federal University of Rio de Janeiro | Palermo L.,Federal University of Rio de Janeiro
British Journal of Radiology | Year: 2012

Metastatic pulmonary calcification is a consequence of calcium deposition in the normal pulmonary parenchyma, secondary to abnormal calcium metabolism. The most characteristic radiological manifestation is poorly defined nodular opacities that are mainly seen in the upper lung zone. The aim of this report is to describe the CT and MRI findings observed in two patients with metastatic pulmonary calcification. The disease may present in CT as consolidations with calcification, and with a high lesion/ muscle signal intensity ratio on T 1 weighted imaging without contrast in MRI. The high signal on T 1 weighted imaging probably occurs because the low calcium concentration of the lesion changes the surface effects of diamagnetic calcium particles, causing T 1 shortening of water protons. MRI is a good option for characterising calcium accumulation caused by a metabolic disorder. © 2012 The British Institute of Radiology.

Hochhegger B.,Santa Casa de Porto Alegre | Marchiori E.,Federal University of Fluminense | Sedlaczek O.,University of Heidelberg | Irion K.,Liverpool Heart and Chest Hospital | And 5 more authors.
British Journal of Radiology | Year: 2011

Imaging studies play a critical role in the diagnosis and staging of lung cancer. CT and 18-fluorodeoxyglucose positron emission tomography CT (PET/CT) are widely and routinely used for staging and assessment of treatment response. Many radiologists still use MRI only for the assessment of superior sulcus tumours, and in cases where invasion of the spinal cord canal is suspected. MRI can detect and stage lung cancer, and this method could be an excellent alternative to CT or PET/CT in the investigation of lung malignancies and other diseases. This pictorial essay discusses the use of MRI in the investigation of lung cancer. © 2011 The British Institute of Radiology.

Leonardi D.,Burns Unit | Oberdoerfer D.,Federal University of Rio Grande do Sul | Fernandes M.C.,Federal University of Health Sciences, Porto Alegre | Meurer R.T.,Federal University of Health Sciences, Porto Alegre | And 7 more authors.
Burns | Year: 2012

Autografts represent the gold standard for the treatment of full thickness burns. Factors such as lack of suitable donor sites and poor skin quality, however, have led to the development of artificial dermal substitutes. The investigation of mechanisms leading to enhanced functionality of these skin substitutes has been attracting great attention. This study aimed to investigate the effect of autologous stem cells on the integration and vascularization of a dermal substitute in full-thickness skin wounds, in a murine model. Two cell populations were compared, whole bone marrow cells and cultivated mesenchymal stem cells, isolated from mice transgenic for the enhanced green fluorescent protein, which allowed tracking of the transplanted cells. The number of cells colonizing the dermal substitute, as well as vascular density, were higher in mice receiving total bone marrow and particularly mesenchymal stem cells, than in control animals. The effect was more pronounced in animals treated with mesenchymal stem cells, which located primarily in the wound bed, suggesting a paracrine therapeutic mechanism. These results indicate that combining mesenchymal stem cells with artificial dermal substitutes may represent an important potential modality for treating full thickness burns, even in allogeneic combinations due to the immunoregulatory property of these cells. © 2012 Elsevier Ltd and ISBI.

Belem L.C.,Federal University of Rio de Janeiro | Zanetti G.,Federal University of Rio de Janeiro | Hochhegger B.,Santa Casa de Porto Alegre | Guimaraes M.D.,Camargo Cancer Center | And 4 more authors.
Respiratory Medicine | Year: 2014

Metastatic pulmonary calcification (MPC) is a subdiagnosed metabolic lung disease that is commonly associated with end-stage renal disease. This interstitial process is characterized by the deposition of calcium salts predominantly in the alveolar epithelial basement membranes. MPC is seen at autopsy in 60-75% of patients with renal failure. It is often asymptomatic, but can potentially progress to respiratory failure. Chest radiographs are frequently normal or demonstrate confluent or patchy airspace opacities. Three patterns visible on high-resolution computed tomography have been described: multiple diffuse calcified nodules, diffuse or patchy areas of ground-glass opacity or consolidation, and confluent high-attenuation parenchymal consolidation. The relative stability of these pulmonary infiltrates, in contrast to infectious processes, and their resistance to treatment, in the clinical context of hypercalcemia, are of diagnostic value. Scintigraphy with bone-seeking radionuclides may demonstrate increased radioactive isotope uptake. The resolution of pulmonary calcification in chronic renal failure may occur after parathyroidectomy, renal transplantation, or dialysis. Thus, the early diagnosis of MPC is beneficial. The aim of this review is to describe the main clinical, pathological, and imaging aspects of MPC. © 2014 Elsevier Ltd. All rights reserved.

Linden-Junior E.,Private Practice | Becker J.,Grande Rio University | Schestatsky P.,Federal University of Rio Grande do Sul | Rotta F.T.,Santa Casa de Porto Alegre | And 2 more authors.
Arquivos de Neuro-Psiquiatria | Year: 2013

Objective: To determine the prevalence of amyotrophic lateral sclerosis (ALS) in the city of Porto Alegre, Brazil. Method: We conducted an extensive investigation in clinics and hospitals that provide specialized assistance to these patients, contacted neurologists and the regional association of people with ALS. Results: On July 31, 2010, 70 patients were alive and diagnosed with amyotrophic lateral sclerosis. Consi dering the population living in the city in the same period (1,409,351), the estimated prevalence was 5.0 cases per 100,000 people (95% CI, 3.9-6.2), being higher for men (5.2/100,000 95% CI, 3.6-7.2) than for women (4.8/100,000 95% CI, 3.4-6.5). The prevalence increased with age peaking in the age group 70-79 years in both genders. Conclusion: The prevalence of ALS in the city of Porto Alegre is similar to that reported in other parts of the world.

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