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Kucuk A.,University of Konya | Uslu A.U.,Kangal State Hospital | Ugan Y.,Sanliurfa Research and Education Hospital | Bagcaci S.,University of Konya | And 4 more authors.
Bratislava Medical Journal | Year: 2015

OBJECTIVE: Ankylosing spondylitis (AS) is a progressive chronic inflammatory disease mainly characterized by axial skeleton and sacroiliac joint involvement. We aimed to investigate the relation between neutrophil-tolymphocyte ratio (NLR) and disease severity of AS and to explore its availability in clinical practice. METHODS: A total of 102 AS patients and 60 individuals who were age- and gender-compatible with the control group were included into the study. Patients were divided into 2 groups according to Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) scores. Patients with BASDAI scores < 4 were considered to be having mild disease activity, whereas those with scores ≥ 4 were considered to be displaying severe disease activity. Hemogram test during the diagnosis, erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) and other laboratory values of the control group were recorded. RESULTS: NLR was observed to be higher in AS patients compared to the controls (2.47 ± 1.33 and 1.72 ± 0.47; respectively; p < 0.0001). NLR was observed to be significantly higher in severe AS disease activity compared to the mild AS disease activity (2.72 ± 1.41, 2.20 ± 1.19; respectively; p = 0.001). NLR had statistical significant differences between mild disease activity compared to the controls (2.20 ± 1.19 and 1.72 ± 0.47, respectively; p = 0.263). There was a positive correlation between NLR and BASDAI (r = 0.193, p = 0.041). The performance of NLR evaluating the disease severity by Roc analysis had sensitivity of 69%, specificity of 54% (cut-offvalue 1.91), and AUC of 0.652 (95% Cl, 0.549-0.755) (p = 0.006). CONCLUSIONS: NLR may be a simple and inexpensive marker to indicate disease activity in patients with AS in daily clinical practice.

Kucukdurmaz Z.,Sanliurfa Research and Education Hospital | Sezen Y.,Harran University | Yildiz S.,Harran University | Buyukhatipoglu H.,Harran University
European Journal of General Medicine | Year: 2011

Co-existence of coronary and cerebral aneurysms is rare, though coronary and cerebral aneurysms are not infrequent. We present a case with this co-existence of coronary and cerebral aneurysms presented with ST segment elevation myocardial infarction and cerebrovascular event.

Kocer N.E.,Baskent University | Kose F.,Sanliurfa Research and Education Hospital | Kayaselcuk F.,Baskent University | Besen A.,Baskent University | And 3 more authors.
UHOD - Uluslararasi Hematoloji-Onkoloji Dergisi | Year: 2013

Fascin is an actin-bundling protein that is expressed by dendritic cells of the lymphoid tissue. Fascin expression is also seen in the neoplastic cells of classical Hodgkin lymphomas, nearly half of the anaplastic lymphomas and in some diffuse large B-cell lymphomas. We aimed to investigate the clinical significance of fascin expression in CD20 positive diffuse large B-cell lymphomas (DLBCL) in patients treated with cyclophosphamide, doxorubicin, vincristine, and prednisolone plus rituximab (R-CHOP). Thirtyfour of the 55 patients included in the study showed fascin expression, 16 of them being diffuse and strong. There was no statistically significant correlation between fascin expression and overall survival and disease-free survival, sex, disease stage, chemotherapy response, whether or not having bulky disease, extranodal involvement, and international prognostic index (IPI) score. The study has failed to show prognostic significance of fascin expression in DLBCL patients treated with R-CHOP. However, because of the alterations in fascin expression in a variety of benign and malignant lymphoid entities, regardless of its prognostic impact, studies on fascin expression may help us to understand tumor biology of lymphomas better.

Oncel R.C.,Akdeniz University | Ucar M.,Akdeniz University | Karakas M.S.,Nigde State Hospital | Akdemir B.,Burdur State Hospital | And 4 more authors.
Clinical and Applied Thrombosis/Hemostasis | Year: 2015

In this study, we aimed to investigate the association of the neutrophil-to-lymphocyte ratio (NLR) with Global Registry of Acute Coronary Events (GRACE) risk score in patients with ST-segment elevated myocardial infarction (STEMI). We analyzed 101 consecutive patients with STEMI. Patients were divided into 3 groups by use of GRACE risk score. The association between NLR and GRACE risk score was assessed. The NLR showed a proportional increase correlated with GRACE risk score (P <.001). The occurrence of in-hospital cardiac death, reinfarction, or new-onset heart failure was significantly related to NLR at admission (P <.001). Likewise, NLR and GRACE risk score showed a significant positive correlation (r =.803, P <.001). In multivariate analysis, NLR resulted as a predictor of worse in-hospital outcomes independent of GRACE risk score. Our study suggests that the NLR is significantly associated with adverse in-hospital outcomes, independent of GRACE risk score in patients with STEMI. © 2014 The Author(s).

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