Wonju, South Korea
Wonju, South Korea

Sangji University is a private university located in Wonju, Gangwon Province, South Korea. Established in 1955, it has seven colleges and six graduate schools. Its top areas of study are Oriental Medicine and Tourism. The Sangji Foundation also manages Sangji Yeongseo College and Sangji Girls Middle and High Schools. Wikipedia.

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Kim S.-H.,Daejeon University | Hong J.-H.,Sangji University | Lee Y.-C.,Sangji University
European Journal of Pharmacology | Year: 2013

Allergic asthma is a chronic airway disorder characterized by airway hyperresponsiveness to allergens, chronic airway inflammation, airway edema, increased mucus secretion, excess production of Th2 cytokines, and eosinophil accumulation in the lungs. Ursolic acid is known for its pharmacological effects, such as its anti-tumor, anti-inflammatory and antimicrobial activities. To investigate the anti-asthmatic effects and mechanism of ursolic acid, we studied the development of pulmonary eosinophilic inflammation and enhanced pause (Penh) in a mouse model of allergic asthma. In this study, BALB/c mice were systemically sensitized to ovalbumin followed by intratracheal, intraperitoneal, and aerosol allergen challenges. We investigated the effect of ursolic acid and Cyclosporin A (CsA) on Penh, pulmonary eosinophilic infiltration, various immune cell phenotypes, Th2 cytokines, IL-17 production, and ovalbumin specific IgE production in a mouse model of asthma. In BALB/c mice, ursolic acid had suppressed eosinophil infiltration, allergic airway inflammation, and Penh, which occurred by suppressing the production of IL-5, IL-13, IL-17, and ovalbumin-specific IgE by blocking the GATA-3 and STAT6 pathways. Our data suggest the therapeutic mechanism of ursolic acid in asthma is based on reductions of Th2 cytokines (IL-5 and IL-13), ovalbumin-specific IgE production, and eosinophil infiltration via the Th2-GATA-3, STAT6, and IL-17-NF-κB pathways. © 2012 Elsevier B.V. All rights reserved.


Jung H.,Sangji University | Chung K.,Sangji University
Information Technology and Management | Year: 2016

As the basic paradigm of health management has changed from diagnosis and treatment to preventative management, health improvement and management has received growing attention in societies around the world. Recently the number of obese youth has risen globally and obesity has caused serious problems regarding almost all of the diseases of these days. This study presents dietary nutrition recommendations based on knowledge for obese youth. The knowledge-based dietary nutrition recommendations herein include not only static dietary nutritional data but also individualized diet menus for them by utilizing knowledge-based context data through a collaborative filtering method. The suggested method utilizes the basic information on obese youth, forms a similarity clustering with a high correlation, applies the similarity weight on {user-menu} matrix within the similarity clustering and utilizes the knowledge based collaborative filtering to recommend the dietary nutritional menu. Also by using the knowledge-based context-aware modeling, the study constitutes a {user-menu} merge matrix and solves the sparse problem of previous recommendation system. The suggested method herein, unlike the conventional uniformed dietary nutrition recommendations for obesity management, is capable of providing the personalized recommendations. Also through mobile devices, users can receive personalized recipes and menus anytime and anywhere. By using the proposed method, the researcher develops a mobile application of dietary nutrition recommendation service for obese management. A mobile interface will be built herein and applied in an experiment to test its logical validity and effectiveness. © 2015, Springer Science+Business Media New York.


Hwang G.-H.,Sangji University | Cho J.-Y.,Sangji University
Journal of Industrial Microbiology and Biotechnology | Year: 2014

Recently, Corynebacterium glutamicum has been shown to exhibit gluconate bypass activity, with two key enzymes, glucose dehydrogenase (GDH) and gluconate kinase, that provides an alternate route to 6-phosphogluconate formation. In this study, gene disruption analysis was used to examine possible metabolic functions of three proteins encoded by open reading frames having significant sequence similarity to GDH of Bacillus subtilis. Chromosomal in-frame deletion of three genes (NCgl0281, NCgl2582, and NCgl2053) encoding putative NADP +-dependent oxidoreductases led to the absence of GDH activity and correlated with increased specific glucose 6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase activities. This finding suggested that enhanced carbon flux from glucose was directed toward the oxidative pentose phosphate (PP) pathway, when the mutant was cultivated with 6 % glucose. Consequently, the mutant showed 72.4 % increased intracellular NADPH and 66.3 % increased extracellular l-ornithine production. The enhanced activities of the oxidative PP pathway in the mutant explain both the increased intracellular NADPH and the high extracellular concentration of l-ornithine. Thus, the observed metabolic changes in this work corroborate the importance of NADPH in l-ornithine production from C. glutamicum. © 2014 Society for Industrial Microbiology and Biotechnology.


Kim S.-H.,Sangji University | Chung K.-Y.,Sangji University
Multimedia Tools and Applications | Year: 2014

This paper describes the development of a 3D simulator that enables a user to analyze the stability of a finite slope causing plane activity among a range of slopes comprised of a finite slope and infinite slope. Until now, there has been considerable theory and research into slope stability. Nevertheless, few systems can be confirmed directly by simulating the stability analysis of a slope, such as landslides. In: other words, virtual experiments, such as the analysis of the slope, cannot be performed due to the absence of a system. For that reason, in this study, a 3D simulator was developed for stability analysis of a finite slope causing plane activity from the landslide phenomena that actually occurred or had very high probability. The Nvidia PhysX, which is utilized to develop computer games and simulators, was used to develop a 3D simulator with physical features. In: addition, OpenGL was used to provide a three-dimensional visual effect from the simulator. In: this paper, the values of each variable were determined to confirm whether landslides can occur easily when the factor of safety (F s ) was within a certain range in the 3D simulator. The 3D simulator developed in this paper was found to be quite useful because it can verify visually whether landslides occur easily in different environments and conditions. © 2013 Springer Science+Business Media New York.


Chu Y.H.,Sangji University | Shul Y.G.,Yonsei University
International Journal of Hydrogen Energy | Year: 2010

Low-temperature direct alcohol fuel cells fed with different kinds of alcohol (methanol, ethanol and 2-propanol) have been investigated by employing ternary electrocatalysts (Pt-Ru-Sn) as anode catalysts. Combinatorial chemistry has been applied to screen the 66-PtRuSn-anode arrays at the same time to reduce cost, time, and effort when we select the optimum composition of electrocatalysts for DAFCs (Direct Alcohol Fuel Cells). PtRuSn (80:20:0) showed the lowest onset potential for methanol electro-oxidation, PtRuSn (50:0:50) for ethanol, and PtRuSn (20:70:10) for 2-propanol in CV results respectively, and single cell performance test indicated that Ru is more suitable for direct methanol fuel cell system, Sn for direct ethanol fuel cell system, and 2-propanol could be applied as fuel with low platinum composition anode electrocatalyst. The single cell performance results and electrochemical results (CV) were well matched with the combinatorial electrochemical results. As a result, we could verify the availability of combinatorial chemistry by comparing the results of each extreme electrocatalysts compositions as follows: PtRuSn (80:20:0) for methanol, PtRuSn (50:0:50) for ethanol and PtRuSn (20:70:10) for 2-propanol. © 2009 Professor T. Nejat Veziroglu. Published by Elsevier Ltd. All rights reserved.


Chung K.-Y.,Sangji University
Multimedia Tools and Applications | Year: 2014

As ubiquitous commerce using IT convergence technologies is coming, it is important for the strategy of cosmetic sales to investigate the sensibility and the degree of preference in the environment for which the makeup style has changed focusing on being consumer centric. The users caused the diversification of the facial makeup styles, because they seek makeup and individuality to satisfy their needs. In this paper, we proposed the effect of the facial makeup style recommendation on visual sensibility. Development of the facial makeup style recommendation system used a user interface, sensibility analysis, weather forecast, and collaborative filtering for the facial makeup styles to satisfy the user's needs in the cosmetic industry. Collaborative filtering was adopted to recommend facial makeup style of interest for users based on the predictive relationship discovered between the current user and other previous users. We used makeup styles in the survey questionnaire. The pictures of makeup style details, such as foundation, color lens, eye shadow, blusher, eyelash, lipstick, hairstyle, hairpin, necklace, earring, and hair length were evaluated in terms of sensibility. The data were analyzed by SPSS using ANOVA and factor analysis to discover the most effective types of details from the consumer's sensibility viewpoint. Sensibility was composed of three concepts: contemporary, mature, and individual. The details of facial makeup styles were positioned in 3D-concept space to relate each type of detail to the makeup concept regarding a woman's cosmetics. Ultimately, this paper suggests empirical applications to verify the adequacy and the validity of this system. © 2013 Springer Science+Business Media New York.


Chwinamul is a mountainous vegetable that refers to several species belonging to the family Compositae. Chwinamul has been used as a side dish or a medicinal herb to treat hypercholesterolemia, diabetes, common cold, atherosclerosis, and cardiovascular disease. Caffeoylquinic acids (CQs) are present in high levels in chwinamul, though caffeoyltartaric acids (CTs) are often occurred in the vegetables of Compositae. Here I review the chemical and pharmaceutical aspects of CQs and CTs. In particular, 13C-NMR data and CQ stereochemistry are discussed. CQ derivatives have antioxidative, peroxynitrite-scavenging, hepatoprotective, antiviral, antiobese, and antidiabetic activities.


Kang S.-K.,Inha University | Chung K.-Y.,Sangji University | Lee J.-H.,Inha University
Personal and Ubiquitous Computing | Year: 2014

This paper proposes a technique for the detection of head nod and shake gestures based on eye tracking and head motion decision. The eye tracking step is divided into face detection and eye location. Here, we apply a motion segmentation algorithm that examines differences in moving people's faces. This system utilizes a Hidden Markov Model-based head detection module that carries out complete detection in the input images, followed by the eye tracking module that refines the search based on a candidate list provided by the preprocessing module. The novelty of this paper is derived from differences in real-time input images, preprocessing to remove noises (morphological operators and so on), detecting edge lines and restoration, finding the face area, and cutting the head candidate. Moreover, we adopt a K-means algorithm for finding the head region. Real-time eye tracking extracts the location of eyes from the detected face region and is performed at close to a pair of eyes. After eye tracking, the coordinates of the detected eyes are transformed into a normalized vector of x-coordinate and y-coordinate. Head nod and shake detector uses three hidden Markov models (HMMs). HMM representation of the head detection can estimate the underlying HMM states from a sequence of face images. Head nod and shake can be detected by three HMMs that are adapted by a directional vector. The directional vector represents the direction of the head movement. The vector is HMMs for determining neutral as well as head nod and shake. These techniques are implemented on images, and notable success is notified. © 2013 Springer-Verlag London.


Patent
Yonsei University and Sangji University | Date: 2015-11-09

Disclosed herein is a bidirectional alternating application system for preventing or treating a brain tumor caused by malignant glioma cells in animals. The bidirectional alternating magnetic field application system can apply a magnetic field having weak intensity and low frequency to patients in need of the prevention or treatment of brain tumor to thereby specifically inhibit the proliferation and mobility of glioma cells without causing any damage to normal cells. Thus, the bidirectional alternating magnetic field application system can greatly reduce side effects occurring in patients after surgery.


Kim J.,BIT Computer Co. | Chung K.-Y.,Sangji University
Multimedia Tools and Applications | Year: 2014

To establish real u-healthcare environments, it is necessary to receive the context information obtained from various platforms at the proper time in portable devices which operate using both wired and wireless communication. Moreover, a knowledge model is required that reflects the information and characteristics needed for such services while remaining appropriate for medical reference. This paper develops an ontology-based healthcare context information model to implement a ubiquitous environment. Contextual information will be extracted and classified to implement the healthcare services using the context information model. The healthcare context information model can be defined using the ontology, and a common healthcare model will be developed by considering medical references and service environments. Application and healthcare service developers can use the sensed information in various environments by authoring device- and space-specific ontologies based on this common ontology. In addition, this paper designs a personalized u-healthcare service system. The validity of the model used in this study is evaluated for the food and exercise recommendation in u-healthcare services. © 2011 Springer Science+Business Media, LLC.

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