Richmond, CA, United States

Sangamo BioSciences

www.sangamo.com
Richmond, CA, United States
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Patent
Sangamo BioSciences | Date: 2017-03-22

Methods and compositions for treatment of a genetic disease are provided. Specifically, the disclosure provides a fusion molecule comprising a DNA-binding domain and a functional domain (e.g., a cleavage domain). The fusion molecule may comprise an engineered nuclease that binds to target site in a region of interest in a genome for genome editing. Further disclosed are methods for altering the expression of one or more genes involved in a genetic disease (e.g., genes producing microRNAs).


Patent
Sangamo BioSciences and CHDI Foundation Inc. | Date: 2017-03-15

Disclosed are methods and compositions for treating or preventing Huntingtons Disease (HD). Specifically, provided are methods and compositions for reducing and/or eliminating Huntingtin (Htt) aggregates, ameliorating motor deficits, increasing cellular activity (e.g., ATP activity), and/or reducing apoptosis in subject with HD, the methods comprising administering a repressor of a mutant Htt (mHtt) allele to the subject. Further disclosed are methods of diagnosis of HD and/or monitoring the disease progression comprising detecting mHtt in a subject.


The present disclosure is in the field of genome engineering, particularly regulating targeted modification of the genome.


Patent
Sangamo BioSciences | Date: 2017-01-04

Disclosed herein are methods and compositions for targeted, nuclease-mediated insertion of transgene sequences into the genome of a cell.


Patent
Sangamo BioSciences and Doyon | Date: 2017-04-12

Methods and compositions for genetic alteration of cells are provided.


Patent
Sangamo BioSciences | Date: 2017-04-12

Methods and compositions for genetic alteration of cells are provided.


Patent
Sangamo BioSciences | Date: 2017-04-19

The present invention relates to organisms which are homozygous for targeted modification of one or more endogenous genes. More specifically, the invention concerns organisms (e.g., plants or animals) in which both alleles of a gene are disrupted but in which the homozygous knockout organism does not contain exogenous sequences at the disrupted locus. The invention also concerns organisms (e.g., plants or animals) in which both alleles of a gene are modified by insertion of a transgene, wherein the transgene lacks sequences encoding a reporter (e.g., selectable marker).


Patent
Sangamo BioSciences and Sigma-Aldrich | Date: 2017-04-19

Disclosed herein are methods and compositions for genome editing of one or more loci in a rat, using fusion proteins comprising a zinc-finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding said fusion proteins are also provided, as are cells comprising said polynucleotides and fusion proteins.


Patent
Sangamo BioSciences | Date: 2017-04-19

Disclosed herein are polypeptides, polynucleotides encoding, cells and organisms comprising novel DNA-binding domains, including TALE DNA-binding domains. Also disclosed are methods of using these novel DNA-binding domains for modulation of gene expression and/or genomic editing of endogenous cellular sequences.


Patent
Sangamo BioSciences | Date: 2017-09-27

Disclosed herein are methods and compositions for targeted cleavage of a genomic sequence, targeted alteration of a genomic sequence, and targeted recombination between a genomic region and an exogenous polynucleotide homologous to M the genomic region. The compositions include fusion proteins comprising a cleavage domain (or cleavage half-domain) and an engineered zinc finger domain and polynucleotides encoding same. Methods for targeted cleavage include introduction of such fusion proteins, or polynucleotides encoding same, into a cell. Methods for targeted recombination additionally include introduction of an exogenous polynucleotide homologous to a genomic region into cells comprising the disclosed fusion proteins.

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