Dow AgroSciences and Sangamo BioSciences | Date: 2016-10-13
Methods and compositions for gene disruption, gene editing or gene stacking within a FAD2 loci by cleaving, in a site directed manner, a location in a FAD2 gene in a soybean cell, to generate a break in the FAD2 gene and then optionally integrating into the break a nucleic acid molecule of interest is disclosed.
Sangamo BioSciences | Date: 2016-10-14
Disclosed herein are compositions comprising non-naturally occurring zinc finger domains, fusion proteins comprising these zinc finger domains, polynucleotides encoding these proteins, cells expressing these proteins and pharmaceutical compositions comprising these proteins or polynucleotides as well as methods of modifying an Htt gene using these compositions for treating or preventing Huntingtons Disease.
Dow AgroSciences and Sangamo BioSciences | Date: 2016-12-14
Disclosed herein are methods and compositions for targeted modification of one or more endogenous plant malate dehydrogenase genes.
Dow AgroSciences and Sangamo BioSciences | Date: 2016-09-21
Disclosed herein are zinc fingers comprising CCHC zinc coordinating residues. Also disclosed are zinc finger proteins and fusion proteins comprising these CCHC zinc fingers as well as polynucleotides encoding these proteins. Methods of using these proteins for gene editing and gene regulations are also described.
Sangamo BioSciences and University of Washington | Date: 2016-06-03
The present disclosure is in the field of genome engineering, particularly targeted modification of the genome of a hematopoietic cell.
Sangamo BioSciences | Date: 2016-06-22
Sangamo BioSciences | Date: 2016-02-03
Disclosed herein are methods and compositions for targeted integration of an exogenous sequence into the human PPP1R12C locus, for example, for expression of a polypeptide of interest.
Sangamo BioSciences | Date: 2016-01-07
Disclosed herein are donor molecules comprising single-stranded complementary regions flanking one or more sequences of interest. The donor molecules and/or compositions comprising these molecules can be used in methods for targeted integration of an exogenous sequence into a specified region of interest in the genome of a cell.
Sangamo BioSciences and Children's Hospital of Philadelphia | Date: 2016-01-28
Cells and methods of using these cells for expressing a transgene expressing a protein that is aberrantly expressed in a metabolic disorders from a safe harbor locus.
Sangamo BioSciences | Date: 2016-01-27
Disclosed herein are compositions and methods for generating chromosomal translocations and targeted deletions of specific lengths and at specific locations the genome of cell.