Richmond, CA, United States

Sangamo BioSciences

www.sangamo.com
Richmond, CA, United States

Time filter

Source Type

Patent
Sangamo BioSciences | Date: 2016-09-23

Disclosed herein are Htt repressors and methods and compositions for use of these Htt repressors.


Described herein are constructs used for liver-specific expression of a transgene.


Patent
Sangamo BioSciences and CHDI Foundation Inc. | Date: 2017-03-15

Disclosed are methods and compositions for treating or preventing Huntingtons Disease (HD). Specifically, provided are methods and compositions for reducing and/or eliminating Huntingtin (Htt) aggregates, ameliorating motor deficits, increasing cellular activity (e.g., ATP activity), and/or reducing apoptosis in subject with HD, the methods comprising administering a repressor of a mutant Htt (mHtt) allele to the subject. Further disclosed are methods of diagnosis of HD and/or monitoring the disease progression comprising detecting mHtt in a subject.


Patent
Biogen, Maxcyte Inc. and Sangamo BioSciences | Date: 2016-11-09

Disclosed herein are methods and compositions for increasing RNA activity in a cell.


Patent
Sangamo BioSciences | Date: 2017-04-12

Methods and compositions for genetic alteration of cells are provided.


Patent
Sangamo BioSciences | Date: 2017-03-22

Methods and compositions for treatment of a genetic disease are provided. Specifically, the disclosure provides a fusion molecule comprising a DNA-binding domain and a functional domain (e.g., a cleavage domain). The fusion molecule may comprise an engineered nuclease that binds to target site in a region of interest in a genome for genome editing. Further disclosed are methods for altering the expression of one or more genes involved in a genetic disease (e.g., genes producing microRNAs).


Patent
Sangamo BioSciences | Date: 2016-12-15

Disclosed herein are methods and compositions for inactivating MHC genes, using zinc finger nucleases (ZFNs) comprising a zinc finger protein and a cleavage domain or cleavage half-domain in conditions able to preserve cell viability. Polynucleotides encoding ZFNs, vectors comprising polynucleotides encoding ZFNs and cells comprising polynucleotides encoding ZFNs and/or cells comprising ZFNs are also provided.


The present disclosure is in the field of genome engineering, particularly regulating targeted modification of the genome.


Patent
Sangamo BioSciences | Date: 2017-07-26

Nucleases and methods of using these nucleases for inserting a sequence encoding a therepeutic protein such as an enzyme into a cell, thereby providing proteins or cell therapeutics for treatment and/or prevention of a lysosomal storage disease.


Patent
Sangamo BioSciences | Date: 2016-12-15

Disclosed herein are compositions for linking DNA binding domains and cleavage domains (or cleavage half-domains) to form non-naturally occurring nucleases with alternative configurations. Also described are methods of making and using compositions comprising these linkers.

Loading Sangamo BioSciences collaborators
Loading Sangamo BioSciences collaborators