Richmond, CA, United States
Richmond, CA, United States

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Methods and compositions for gene disruption, gene editing or gene stacking within a FAD2 loci by cleaving, in a site directed manner, a location in a FAD2 gene in a soybean cell, to generate a break in the FAD2 gene and then optionally integrating into the break a nucleic acid molecule of interest is disclosed.


Patent
Sangamo BioSciences | Date: 2016-10-14

Disclosed herein are compositions comprising non-naturally occurring zinc finger domains, fusion proteins comprising these zinc finger domains, polynucleotides encoding these proteins, cells expressing these proteins and pharmaceutical compositions comprising these proteins or polynucleotides as well as methods of modifying an Htt gene using these compositions for treating or preventing Huntingtons Disease.


Patent
Dow AgroSciences and Sangamo BioSciences | Date: 2016-12-14

Disclosed herein are methods and compositions for targeted modification of one or more endogenous plant malate dehydrogenase genes.


Patent
Sangamo BioSciences | Date: 2016-09-23

Disclosed herein are Htt repressors and methods and compositions for use of these Htt repressors.


Described herein are constructs used for liver-specific expression of a transgene.


Patent
Sangamo BioSciences and CHDI Foundation Inc. | Date: 2017-03-15

Disclosed are methods and compositions for treating or preventing Huntingtons Disease (HD). Specifically, provided are methods and compositions for reducing and/or eliminating Huntingtin (Htt) aggregates, ameliorating motor deficits, increasing cellular activity (e.g., ATP activity), and/or reducing apoptosis in subject with HD, the methods comprising administering a repressor of a mutant Htt (mHtt) allele to the subject. Further disclosed are methods of diagnosis of HD and/or monitoring the disease progression comprising detecting mHtt in a subject.


Patent
Biogen, Maxcyte Inc. and Sangamo BioSciences | Date: 2016-11-09

Disclosed herein are methods and compositions for increasing RNA activity in a cell.


Patent
Sangamo BioSciences | Date: 2017-04-12

Methods and compositions for genetic alteration of cells are provided.


Patent
Sangamo BioSciences | Date: 2017-03-22

Methods and compositions for treatment of a genetic disease are provided. Specifically, the disclosure provides a fusion molecule comprising a DNA-binding domain and a functional domain (e.g., a cleavage domain). The fusion molecule may comprise an engineered nuclease that binds to target site in a region of interest in a genome for genome editing. Further disclosed are methods for altering the expression of one or more genes involved in a genetic disease (e.g., genes producing microRNAs).


Patent
Sangamo BioSciences | Date: 2016-06-22

Disclosed herein are methods and compositions for modulating expression of a PD1 gene.

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