Prieto-Andres A.,San Jorge University
Profesional de la Informacion | Year: 2017
Immigration and its regulation are key issues in society and, as such, are subject to political discourses that show the arguments of the different social actors, especially political parties. Press is one of the main mechanisms used by these social actors to show such discourses. Hence, this paper analyzes how six Spanish newspapers presented the political discourses on the Foreigners law, as the main legal-political instrument to manage immigration, from 2003 to 2016, as well as the position of the political parties that were the main sources of discourse. To achieve this, we worked with the Zapata-Barrero model, which categorizes political discourses on immigration into two types: pro-Active discourses and re-Active discourses, which shows their preference for managing multiculturalism as a challenge or a problem, respectively.
Coetzee D.D.,Stellenbosch University |
Lopez V.,San Jorge University |
Smith C.,Stellenbosch University
Journal of Ethnopharmacology | Year: 2016
Ethnopharmacological relevance Extracts from and alkaloids contained in plants in the genus Sceletium have been reported to inhibit ligand binding to serotonin transporter. From this, the conclusion was made that Sceletium products act as selective serotonin-reuptake inhibitors. However, other mechanisms which may similarly result in the anxiolytic or anti-depressant effect ascribed to Sceletium, such as monoamine release, have not been investigated. Aims of the study The current study investigated simultaneously and at two consecutive time points, the effect of high-mesembrine Sceletium extract on both monoamine release and serotonin reuptake into both human astrocytes and mouse hippocampal neurons, as well as potential inhibitory effects on relevant enzyme activities. Materials and methods Human astrocytes and mouse hippocampal cells were treated with citalopram or Sceletium extract for 15 and 30 min, after which protein expression levels of serotonin transporter (SERT) and vesicular monoamine transporter-2 (VAMT-2) was assessed using fluorescent immunocytochemistry and digital image analysis. Efficacy of inhibition of acetylcholinesterase (AChE) and monoamine oxidate-A (MAO-A) activity were assessed using the Ellman and Olsen methods (and appropriate controls) respectively. Results We report the first investigation of mechanism of action of Sceletium extract in the context of serotonin transport, release and reuptake in a cellular model. Cell viability was not affected by Sceletium treatment. High-mesembrine Sceletium extract down-regulated SERT expression similarly to citalopram. In addition, VMAT-2 was upregulated significantly in response to Sceletium treatment. The extract showed only relatively mild inhibition of AChE and MAO-A. Conclusions We conclude that the serotonin reuptake inhibition activity ascribed to the Sceletium plant, is a secondary function to the monoamine-releasing activity of high-mesembrine Sceletium extract (TrimesemineTM). © 2015 Elsevier Ireland Ltd.
Sargin S.A.,Alanya Alaaddin Keykubat University |
Selvi S.,Balikesir University |
Lopez V.,San Jorge University
Journal of Ethnopharmacology | Year: 2015
Ethnopharmacological relevance This paper provides new and significant ethnopharmacological information on medicinal plants used by native people who live in Sarigöl and its surroundings in Turkey. Aim of the study To compile herbal remedies from the area of Sarigöl with their traditional uses, parts of the plant used and form of administration as well as to calculate ethnobotanical indices and validate its therapeutic use. Materials and methods Plant samples that have been collected by herbalists or informants from Sarigöl and its surroundings for medical purposes were studied by visiting the villages during the study period, and then brought to the laboratory to identify the species. The relative frequency citation (RFC), use value (UV), informant consensus factor (ICF) and fidelity level (FL) were computed for the plants included in the study as well as a pharmacological validation from International Official sources by using WHO, ESCOP and EMA monographs. Results In this research conducted between 2010 and 2013, 141 taxa affiliated with 55 families, including 3 Gymnosperms, were determined as they used for medical purposes. The study was carried out by visiting 15 villages and 4 herbalist shops identified in Sarigöl and its surroundings. Asteraceae, Lamiaceae, Fabaceae, Rosaceae and Apiaceae have been detected as the most consumed families for medical purposes. The research showed that most of the informants agreed on the use of Vitis vinifera fruits to cure gastrointestinal diseases that demonstrated the highest fidelity level (0.62). Only 31, out of 141, of the species recorded in this study, currently have a monograph with a validated use. Conclusion During the survey, it was observed that local people consumed plants in the form of the infusion, whereas when using hard organs such as bark or branches, decoctions were preferred. It was identified that most of the medicinal plants have been used for gastrointestinal and respiratory disorders, and they are mainly utilized in the form of infusion or decoction. Vitis vinifera has a different traditional use compared to therapeutic indication proposed by monographs from Official sources like ESCOP or EMA. © 2015 Elsevier Ireland Ltd. All rights reserved.
Agency: European Commission | Branch: FP7 | Program: MC-IRSES | Phase: FP7-PEOPLE-2013-IRSES | Award Amount: 174.80K | Year: 2013
MEDCHANGe focuses on the analysis of the relationships between global networks (Internet), flows (virtual and spatial mobilities of individuals, information i.e. migration also in light of gender issues such those of Moroccon female migrants; climate change migrants; tourism and heritage valorisation flows) and geographical localities in terms of local development and marginalisation/segregation. MEDCHANGe will shed lights on changing relationships at the spatial scales of some Mediterranean countries (Algeria, Israel, Italy, Morocco, Portugal, Spain) due to the dialectics of global flows, borders crossing and local structural changes. Our network of scholars will work in synergy and complementarities thru joint field research, workshops and seminars by investigating both the spatial and behavioural origins and development of our topics and their contemporary changing dynamics in selected territorial cases (Tel Aviv, Algier, Lisbon, Marrakesh, Casablanca, Naples-Caserta, Zaragoza, Genoa). In order to achieve this goal, MEDCHANGe activities are structured into three main levels: 1) a theoretical-methodological level; 2) an empirical analysis of case studies in different countries; 3) an operational level. Theoretically we will contribute to the redefinition of the concepts that denote the field of investigation,Mediterranean changing relationships namely mobility, connectivity, gender, heritage,spatial justice, entrepreneurship, inclusion, climate migration, and the idea of the Mediterranean integration in a frame of uneven development. Empirically, we aims to exchange skills, knowledge, expertise, mobilities to document the different ways in which transformations of the Mediterranean cities and villages take place, and grasp the implications of the so-called virtual spatial mobilities in terms of inclusion, citizenship, security, intercultural dialogue. At the operational level we look forward for studying successful stories and practices of cooperation.
Martinez De Yuso A.,San Jorge University |
Rubio B.,CSIC - Institute of Carbochemistry |
Izquierdo M.T.,CSIC - Institute of Carbochemistry
Fuel Processing Technology | Year: 2014
The aim of this work was to compare the effect of different activating atmospheres on the final properties and adsorption performance of activated carbons. Almond shell based activated carbons have been obtained by chemical activation with phosphoric acid. Two sets of activated carbons were prepared. First set was prepared under inert atmosphere at different impregnation ratios, temperatures and times of activation. Second set of activated carbons was prepared at the same activating conditions except the activating atmosphere using an oxidant one. Activated carbons prepared under both activation atmospheres were characterized by elemental analysis (EA), thermogravimetry (TGA), temperature programmed desorption (TPD), point zero charge (PZC), Boehm titration and N2 physisorption. To study the adsorption performance of the activated carbons toluene adsorption-desorption isotherms were determined gravimetrically. The results obtained confirm that the activating atmosphere has a strong influence on the final characteristics of the activated carbons. Activated carbons with higher oxygen content and more negative surface charge have been obtained by changing the activating atmosphere by an oxidant one. Surface area is also higher for activated carbons prepared under oxidant atmosphere. However toluene adsorption capacity is lower for activated carbons prepared under oxidant atmosphere due to their surface chemistry. © 2013 Elsevier B.V.
Lopez V.,San Jorge University |
Calvo M.I.,University of Navarra
Plant Foods for Human Nutrition | Year: 2011
Tea is a popular beverage whose consumption is associated with prevention of certain disorders. The objective of the study was to investigate the potential neuroprotective effect of white tea extract (WTE) on hydrogen peroxide induced toxicity in PC12 cells. Cells were treated with various doses of WTE (10-250 μg/ml) before exposition to 250 μM hydrogen peroxide and cell survival was determined through the MTT and LDH assays. Oxidative stress was quantified in the cells after treatments as intracellular reactive oxygen species (ROS) production and the antioxidant activity of the extract was assessed in a cell free system in terms of free radical scavenging capacity. Results showed that WTE has a significant protective effect in the PC12 cell line against hydrogen peroxide as cell survival was significantly superior in WTE-treated cells compared to hydrogen peroxide-treated cells. A reduction on intracellular oxidative stress as well as radical scavenging properties were produced by WTE. Results suggest that WTE protects PC12 cells against H2O2-induced toxicity, and that an antioxidant mechanism through ROS scavenging may be in part responsible for cells neuroprotection. © 2011 Springer Science+Business Media, LLC.
Herrero P.,San Jorge University
Clinical rehabilitation | Year: 2012
To investigate whether hippotherapy (when applied by a simulator) improves postural control and balance in children with cerebral palsy. Stratified single-blind randomized controlled trial with an independent assessor. Stratification was made by gross motor function classification system levels, and allocation was concealed. Children between 4 and 18 years old with cerebral palsy. Interventions: Participants were randomized to an intervention (simulator ON) or control (simulator OFF) group after getting informed consent. Treatment was provided once a week (15 minutes) for 10 weeks. Gross Motor Function Measure (dimension B for balance and the Total Score) and Sitting Assessment Scale were carried out at baseline (prior to randomization), end of intervention and 12 weeks after completing the intervention. Thirty-eight children participated. The groups were balanced at baseline. Sitting balance (measured by dimension B of the Gross Motor Function Measure) improved significantly in the treatment group (effect size = 0.36; 95% CI 0.01-0.71) and the effect size was greater in the severely disabled group (effect size = 0.80; 95% CI 0.13-1.47). The improvements in sitting balance were not maintained over the follow-up period. Changes in the total score of the Gross Motor Function Measure and the Sitting Assessment Scale were not significant. Hippotherapy with a simulator can improve sitting balance in cerebral palsy children who have higher levels of disability. However, this did not lead to a change in the overall function of these children (Gross Motor Function Classification System level V).
Calvo S.,San Jorge University
International Journal of Rehabilitation Research | Year: 2016
Dry needling for hypertonia and spasticity (DNHS) is a technique used for decreasing hypertonia and spasticity and for the improvement of function in patients with damage to the central nervous system. There is limited evidence supporting the effectiveness of this technique on the basis of objective assessments. The aim of the present case report was to quantify the effects of dry needling (DNHS technique) on the contractile properties of spastic muscles in an individual with stroke. The DNHS technique was applied to a 50-year-old male 2.5 years after stroke who had a complaint of spasticity. The treated muscles were biceps brachii, triceps brachii, rectus femoris, semitendinosus, biceps femoris, medial gastrocnemius, and lateral gastrocnemius. Tensiomyography was used to assess maximal displacement (Dm) of treated muscles. We performed a preintervention and postintervention measurement and a follow-up measurement 3 weeks after intervention. After the application of the DNHS technique, a decrease in the level of local muscle stiffness was observed for all muscles after intervention and at the 3-week follow-up, quantified by an increase in Dm. The usefulness of tensiomyography for detecting changes in patients with spasticity correlated with clinical measures in this field requires further research to establish the reliability of the different parameters provided by the equipment. Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved.
Lopez V.,San Jorge University
Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas | Year: 2011
Traditional medicinal plants have been the origin and basis of pharmacology and therapeutics. On the other side, over the last decades, natural product and medicinal plant research have been cut down within pharmaceutical companies claiming economic and availability reasons. However, traditional medicinal plants have played an important role in drug discovery. For these reason, ethnobotany and traditional medicine may still be a useful strategy and a valuable tool for future pharmaceutical research. © 2011 The Authors.
San Jorge University | Date: 2013-04-03
A electronic management for interactions of a person with a plurality of objects (4) is disclosed. In the persons environment, objects (4) must have an attached electromagnetic tag (1) comprising a unique identification code. The person carries portable reading means (2) to periodically read electromagnetic tags (1) of near objects (4). Processing means (3) receive the identification code previously read together with additional information regarding the location and the time of each reading operation in order to create specific tag reading events (5) that can be grouped for further analysis according to location and temporal values of each read tag (1). Therefore, the processing means can define representative points and to identify individual interactions and then relate interactions in a simpler and more accurate manner.