San Gallicano Dermatologic Institute for Research and Care

Rome, Italy

San Gallicano Dermatologic Institute for Research and Care

Rome, Italy

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Elia F.,San Gallicano Dermatologic Institute for Research and Care | Paolino G.,San Gallicano Dermatologic Institute for Research and Care | Donati M.,San Gallicano Dermatologic Institute for Research and Care | Solivetti F.M.,San Gallicano Dermatologic Institute for Research and Care
Journal of Ultrasound | Year: 2016

Purpose: Multiple miliaryosteoma cutis (MMOC) is a rare nodular skin disease, characterized by tiny bone nodules in the dermis and subcutaneous tissue, presenting clinically as multiple normochromic papules and nodules, usually on the face. We described the case of MMOC of the face in a woman, ultrasonically evaluated with very high frequency probe. Materials and methods: A 45-year-old patient with multiple papules, 3–5 mm in diameter, grouped in the frontal region. Skin ultrasound examination, cutaneous biopsy and laboratory evaluation were performed. Results: High-frequency ultrasound showed the presence of multiple hyperechogenic linear and roundish structures, associated by hypoechogenic shadow. The histology revealed a normal orthokeratotic stratified epithelium with fragment of mature lamellar bone localized at level of the reticular dermis. Laboratory evaluation was normal. According to the clinical, pathological, laboratory and instrumental analyses, a final diagnosis of miliaryosteoma cutis (or primary osteoma cutis not associated with Albright’s hereditary osteodystrophy) was made. Conclusion: In case of multiple papules of subcutaneous tissue, the diagnosis of MMOC, although rare, should be considered and high-frequency sonography, identifying the calcifications, suggests diagnosis. © 2015, Società Italiana di Ultrasonologia in Medicina e Biologia (SIUMB).


Bonadies A.,Dermatologic Institute for Research and Care | Elia F.,San Gallicano Dermatologic Institute for Research and Care | Solivetti F.M.,San Gallicano Dermatologic Institute for Research and Care | Vidiri A.,Regina Elena Cancer Institute | And 2 more authors.
Anticancer Research | Year: 2015

Dermatofibrosarcoma protuberans (DFSP) is an uncommon cutaneous sarcoma with high recurrence rate. Radical surgery is the treatment of choice, although in cosmetically-sensitive areas such as the head and neck, this option is often not pursued. Electrochemotherapy (ECT) is a minimal invasive anti-tumor modality which is increasingly being used to treat skin metastases from different malignancies. A 31-year-old woman presented with subcutaneous local multirecurring DFSP located at the proximal end of the left eyebrow. ECT was offered as a palliative treatment to avoid radical disfiguring surgery. Two days following ECT, the patient was discharged in good general health. Partial tumor regression was appreciable at two months' follow-up by ultrasound and magnetic resonance imaging. At six months, residual fibrotic tissue was observed; at three years, no evidence of the tumour was detected. In our case, ECT achieved good local tumor control with excellent cosmetic results, preserving the patient's quality of life.


Laino L.,San Gallicano Dermatologic Institute for Research and Care | Elia F.,San Gallicano Dermatologic Institute for Research and Care | Desiderio F.,San Gallicano Dermatologic Institute for Research and Care | Scarabello A.,San Gallicano Dermatologic Institute for Research and Care | And 3 more authors.
Journal of Experimental and Clinical Cancer Research | Year: 2015

Background: At skin level, a cancerization field (CF) indicates some chronically photoexposed areas in which, besides a primary tumor, histological or biomolecular modifications without clinical signs are present. Active telethermography (ATT) allows us to observe the imaging of a hyperthermic halo (HH) surrounding the tumor. The Authors hypothesize HH as a possible expression of CF. Objectives: The aim of this study were to verify whether HHs have the same histological or immunohistochemical characteristics as the CF and, secondly, to evaluate the efficacy of a device containing the enzyme photolyase in modifying thermographic parameters in these area. Methods: The study included 30 patients affected by actinic keratosis, evaluated clinically and by ATT at time 0 and after 3, 6 and 9 months. Results: The ATT showed the presence of HHs in all the patients and, after the treatment, a significant modification of both the extension of these areas and the thermal parameters. In 5 patients for whom, while operated, two other biopsies were performed, respectively on the HH and on a perilesional non-hyperthermic area, in the HH, we detected a p53 and Ki 67 over-expression. Conclusions: Our results indicate that ATT could represent a useful paraclinic method in identifying CFs in subjects at risk. © 2015 Laino et al.


PubMed | San Gallicano Dermatologic Institute for Research and Care, Dermatologic Institute for Research and Care and Regina Elena Cancer Institute
Type: Case Reports | Journal: Anticancer research | Year: 2015

Dermatofibrosarcoma protuberans (DFSP) is an uncommon cutaneous sarcoma with high recurrence rate. Radical surgery is the treatment of choice, although in cosmetically-sensitive areas such as the head and neck, this option is often not pursued. Electrochemotherapy (ECT) is a minimal invasive anti-tumor modality which is increasingly being used to treat skin metastases from different malignancies. A 31-year-old woman presented with subcutaneous local multirecurring DFSP located at the proximal end of the left eyebrow. ECT was offered as a palliative treatment to avoid radical disfiguring surgery. Two days following ECT, the patient was discharged in good general health. Partial tumor regression was appreciable at two months follow-up by ultrasound and magnetic resonance imaging. At six months, residual fibrotic tissue was observed; at three years, no evidence of the tumour was detected. In our case, ECT achieved good local tumor control with excellent cosmetic results, preserving the patients quality of life.


PubMed | San Gallicano Dermatologic Institute for Research and Care
Type: Case Reports | Journal: Journal of ultrasound | Year: 2016

Multiple miliaryosteoma cutis (MMOC) is a rare nodular skin disease, characterized by tiny bone nodules in the dermis and subcutaneous tissue, presenting clinically as multiple normochromic papules and nodules, usually on the face. We described the case of MMOC of the face in a woman, ultrasonically evaluated with very high frequency probe.A 45-year-old patient with multiple papules, 3-5mm in diameter, grouped in the frontal region. Skin ultrasound examination, cutaneous biopsy and laboratory evaluation were performed.High-frequency ultrasound showed the presence of multiple hyperechogenic linear and roundish structures, associated by hypoechogenic shadow. The histology revealed a normal orthokeratotic stratified epithelium with fragment of mature lamellar bone localized at level of the reticular dermis. Laboratory evaluation was normal. According to the clinical, pathological, laboratory and instrumental analyses, a final diagnosis of miliaryosteoma cutis (or primary osteoma cutis not associated with Albrights hereditary osteodystrophy) was made.In case of multiple papules of subcutaneous tissue, the diagnosis of MMOC, although rare, should be considered and high-frequency sonography, identifying the calcifications, suggests diagnosis.


PubMed | San Gallicano Dermatologic Institute for Research and Care and Italian National Cancer Institute
Type: | Journal: Journal of experimental & clinical cancer research : CR | Year: 2015

At skin level, a cancerization field (CF) indicates some chronically photoexposed areas in which, besides a primary tumor, histological or biomolecular modifications without clinical signs are present. Active telethermography (ATT) allows us to observe the imaging of a hyperthermic halo (HH) surrounding the tumor . The Authors hypothesize HH as a possible expression of CF.The aim of this study were to verify whether HHs have the same histological or immunohistochemical characteristics as the CF and, secondly, to evaluate the efficacy of a device containing the enzyme photolyase in modifying thermographic parameters in these area.The study included 30 patients affected by actinic keratosis, evaluated clinically and by ATT at time 0 and after 3, 6 and 9months.The ATT showed the presence of HHs in all the patients and, after the treatment, a significant modification of both the extension of these areas and the thermal parameters. In 5 patients for whom, while operated, two other biopsies were performed, respectively on the HH and on a perilesional non-hyperthermic area, in the HH, we detected a p53 and Ki 67 over-expression.Our results indicate that ATT could represent a useful paraclinic method in identifying CFs in subjects at risk.

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