Guzel M.,Samsun Training and Research Hospital |
Salt O.,Yozgat State Hospital
Surgery Today | Year: 2014
Purpose: This study examined the feasibility of using the serum intestinal fatty acid binding protein (I-FABP) level for the early diagnosis of acute mesenteric ischemia, and investigated whether it contributes to the clinical decision-making process.Method: Thirty patients diagnosed with acute mesenteric ischemia, 27 patients with other types of acute abdomen who presented with acute abdomen symptoms but were not diagnosed with acute mesenteric ischemia, and 20 healthy people were included in the study. Mesenteric ischemia was confirmed by a pathological evaluation in patients who underwent intestinal resection due to detection of mesenteric ischemia during surgery.Results: There was no significant difference in the leukocyte counts and d-dimer levels between subjects with mesenteric ischemia and acute abdomen due to other causes (p > 0.05). There was a significant difference in the serum I-FABP level between these groups (p < 0.001).Conclusion: The I-FABP level is a more reliable parameter for diagnosing acute mesenteric ischemia compared to leukocytosis and d-dimer elevation. © 2013, Springer Japan.
Kan E.,Samsun Training and Research Hospital |
Kilickan E.,Samsun Training and Research Hospital |
Ayar A.,Karadeniz Technical University |
Colak R.,Ondokuz Mayis University
International Ophthalmology | Year: 2015
The purpose of this study was to determine whether α-lipoic acid and fisetin have protective effects against cataract in a streptozotocin-induced experimental cataract model. Twenty-eight male BALB/C mice were made diabetic by the intraperitoneal administration of streptozotocin (200 mg/kg). Three weeks after induction of diabetes, mice were divided randomly into 4 groups in which each group contained 7 mice; fisetin-treated group (group 1), α-lipoic acid-treated group (group 2), fisetin placebo group (group 3), α-lipoic acid placebo group (group 4). Fisetin and α-lipoic acid were administered intraperitoneally weekly for 5 weeks. Cataract development was assessed at the end of 8 weeks by slit lamp examination, and cataract formation was graded using a scale. All groups developed at least grade 1 cataract formation. In the fisetin-treated group, the cataract stages were significantly lower than in the placebo group (p = 0.02). In the α-lipoic acid-treated group, the cataract stages were lower than in the placebo group but it did not reach to a significant value. Both fisetin and α-lipoic acid had a protective effect on cataract development in a streptozotocin-induced experimental cataract model. The protective effect of fisetin appears as though more effective than α-lipoic acid. © 2014, Springer Science+Business Media Dordrecht.
Kan E.,Samsun Training and Research Hospital |
Ylmaz A.,Samsun Training and Research Hospital |
Demirag M.D.,Samsun Training and Research Hospital |
Calk M.,Samsun Training and Research Hospital
Seminars in Ophthalmology | Year: 2015
Purpose: To determine the relationship between cerebro vascular disease and pseudoexfoliation syndrome. Materials and Methods: This cross-sectional case control study consisted of 50 patients with ischemic-type cerebro vascular disease and 50 control subjects. All subjects were investigated for diabetes mellitus and hypertension status and underwent a detailed ophthalmic examination. A diagnosis of pseudoexfoliation syndrome was made if characteristic greyish particulate matter was found on the anterior lens capsule after pupillary dilatation by slit-lamp examination. All subjects were compared in terms of pseudoexfoliation syndrome, diabetes mellitus, and hypertension. Pearson Chi Square and Student’s t test were used for statistical analysis. Logistic regression analyses of the risk factors between groups were also made. Results: The presence of pseudoexfoliation syndrome was significantly higher in patients with cerebro vascular disease when compared to the control subjects (p = 0.02). The frequency of diabetes mellitus was similar between the two groups. Arterial hypertension was significantly more frequent in the patient group when compared to the control subjects (p < 0.01). The logistic regression analysis showed that both pseudoexfoliation syndrome and hypertension were significantly associated with cerebro vascular disease. Conclusion: In the present study, we found that pseudoexfoliation syndrome frequency was found to be higher in patients with cerebro vascular disease than in control subjects. A slit-lamp examination of the eye could be an important marker that indicates the risk of cerebro vascular disease. We recommend an evaluation of all subjects with pseudoexfoliation syndrome for the presence of cerebro vascular disease. Longitudinal studies with larger populations are needed to confirm this relationship. © 2015 Informa Healthcare USA, Inc. All rights reserved: reproduction in whole or part not permitted
Iltar S.,Ankara Nuclear Research And Training Center |
Alemdaroglu K.B.,Ankara Nuclear Research And Training Center |
Say F.,Ankara Nuclear Research And Training Center |
Say F.,Samsun Training and Research Hospital |
Aydogan N.H.,Ankara Nuclear Research And Training Center
Bone and Joint Journal | Year: 2013
Redisplacement is the most common complication of immobilisation in a cast for the treatment of diaphyseal fractures of the forearm in children. We have previously shown that the three-point index (TPI) can accurately predict redisplacement of fractures of the distal radius. In this prospective study we applied this index to assessment of diaphyseal fractures of the forearm in children and compared it with other cast-related indices that might predict redisplacement. A total of 76 children were included. Their ages, initial displacement, quality of reduction, site and level of the fractures and quality of the casting according to the TPI, Canterbury index and padding index were analysed. Logistic regression analysis was used to investigate risk factors for redisplacement. A total of 18 fractures (24%) redisplaced in the cast. A TPI value of > 0.8 was the only significant risk factor for redisplacement (odds ratio 238.5 (95% confidence interval 7.063 to 8054.86); p < 0.001). The TPI was far superior to other radiological indices, with a sensitivity of 84% and a specificity of 97% in successfully predicting redisplacement. We recommend it for routine use in the management of these fractures in children. © 2013 The British Editorial Society of Bone and Joint Surgery.
Platelet-rich plasma injection is more effective than hyaluronic acid in the treatment of knee osteoarthritis [Injekce plazmy obohacené destičkovým koncentrátem je efektivnější než kyselina hyaluronová vléčbě gonartrózy]
Say F.,Ondokuz Mayis University |
GURLER D.,Samsun Training and Research Hospital |
Yener K.,Samsun Training and Research Hospital |
BulBul M.,Istanbul University |
Malkoc M.,Istanbul University
Acta Chirurgiae Orthopaedicae et Traumatologiae Cechoslovaca | Year: 2013
PURPOSE OF THE STUDY: There is increasing use of platelet-rich plasma (PRP) in orthopaedics as it is a simple, cheap and minimally invasive technique. This study aimed to compare the effects of the use of PRP and hyaluronic acid (HA) injections in the knee of patients diagnosed with and being followed-up for degenerative arthritis. MATERIALS AND METHODS: This prospective study included 90 patients with complaints of knee pain with findings of mild or moderate degenerative arthritis. In the PRP group (n = 45), one intra-articular injection was applied and in the HA group (n = 45), three doses of intra-articular injection were applied. Clinical evaluation was made by Knee Injury and Osteoarthritis Outcome Score (KOOS) and avisual pain scale. RESULTS: No severe adverse events was observed. Statistically significant better results in the KOOS score and visual pain scale was determined in PRP group than HA group at 3 months and 6 months follow up. The cost of the application for the PRP group was lower than that of the HA group. CONCLUSION The results of this study have shown the application of single dose PRP to be a safe, effective and low-cost method for treating OA. However, further studies are required for amore clear result. © Česká společnost pro ortopedii a traumatologii 2006.
Yagmur C.,Samsun Training and Research Hospital |
Guneren E.,Samsun Training and Research Hospital |
Kefeli M.,Ondokuz Mayis University |
Ogawa R.,Nippon Medical School
Journal of Plastic, Reconstructive and Aesthetic Surgery | Year: 2011
Background: Previous reports have suggested that the extent of wound contraction, epithelisation and total healing time were influenced by denervation of tissues. In this article, we studied for the first time the effect of sensory denervation on prevention of excessive dermal scarring. Materials and Methods: Sixteen New Zealand white rabbits were used. Denervation of the right ears was performed by surgical excision of two main sensory nerves. Dissections were also performed on left ears without any nerve excision for the control group. After 14 days of follow-up and confirmation of tissue denervation, an excessive dermal scarring model as defined by Morris et al. was made by surgery on both ears. Twenty-eight days after making the wounds, the tissues were extirpated for analyses. The scars were evaluated by the scar elevation index (SEI), epithelisation time and inflammatory cell count. Results: The SEI of the denervated side scars was significantly lower than that of the non-denervated side. The rate and timing of total epithelisation and inflammatory cell count between groups yielded no difference. Conclusions: In this study, the surgical denervation skin reduced scarring. It was suggested that understanding the exact role of sensory nerves and neural mediators in excessive dermal scarring is necessary for the prevention and treatment of scarring. © 2011 British Association of Plastic.
Say F.,Ondokuz Mayis University |
Gurler D.,Samsun Training and Research Hospital |
Inkaya E.,Samsun Training and Research Hospital |
Bulbul M.,Istanbul University
Acta Orthopaedica et Traumatologica Turcica | Year: 2014
Objective: The aim of this study was to compare the effects of platelet-rich plasma (PRP) and steroid injections in patients diagnosed with plantar fasciitis. Methods: A total of 50 patients with chronic plantar fasciitis were included in the study and divided into 2 groups. In the PRP group (n=25), PRP taken from the patients' blood was activated using calcium chloride and injected in a single dose. In the steroid group (n=25), a single dose methylprednisolone with local anesthetic injection was given. Clinical evaluation was made using the American Foot and Ankle Score (AFAS) and the visual analog scale (VAS). Results: No complications were seen in any patients. Mean AFAS was 85.5±4.2 at 6 weeks and 90.6±2.6 at 6 months in the PRP group and 75.3±4.8 and 80.3±4.7, respectively, in the steroid group (p<0.001). The difference in the mean VAS between the PRP group (2.4±0.8 and 1±0.8) and the steroid group (4±1.1 and 2.6±0.9) at the 6th week and 6th month was statistically significant (p<0.001). Changes in AFAS and VAS scores were significantly higher in the PRP group (p<0.001). Conclusion: The application of PRP appears to be more effective than steroid injection in terms of pain and functional results in the treatment of chronic plantar fasciitis. © 2014 Turkish Association of Orthopaedics and Traumatology.
Keles M.K.,Konya Numune Hospital |
Demir A.,Ondokuz Mayis University |
Kucuker I.,Ondokuz Mayis University |
Alici O.,Samsun Training and Research Hospital
Microsurgery | Year: 2014
In this study, the histological and vital effects of rotation on multiple and single based perforator flaps were evaluated. A 6 cm × 6 cm abdominal perforator flap model was used on 80 male rats; half of these received a single-pedicled flap, and the other half double-pedicled. The flaps of control subgroups were raised and sutured without rotation. In rotation subgroups 90-, 180-, 270-degree rotations were performed, and rotation effects on flap viability and histological changes were analyzed. Among single- and double-pedicled perforator flaps, respectively, mean survival area was 12.59 cm2 and 27.84 cm2 in non-rotated subgroups, 12.49 cm 2 and 17.06 cm2 in 90-degree rotation subgroups, 5.96 cm2 and 9.96 cm2 in 180-degree rotation subgroups, and 1.45 cm2 and 1.70 cm2 in 270-degree rotation subgroups. While survival areas of double- and single-pedicled perforator flaps with the same rotation degree showed no statistically significant difference, non-rotated double-pedicled perforator flaps had a statistically larger survival area compared to single-pedicled perforator flap (P = 0.001). In the single-pedicled flap group, there were no statistical differences between survival flap areas of the non-rotated subgroup and the 90- and 180-degree rotation subgroups (P > 0.05), but the non-rotated subgroup had a statistically larger survival area compared to the 270-degree rotation subgroup (P = 0.003). In double-pedicled perforator flap group, the control subgroup had a statistically larger flap survival area compared to 90-degree, 180-degree, and 270-degree rotation subgroups (P = 0.004, P = 0.002, P = 0.001). Degenerative histological changes gradually increased in correlation with the rotation angle in both single- and double-pedicled groups. When double- and single-pedicled groups were compared; degenerative histology score displayed no statistical difference between control subgroups and rotated subgroups (P > 0.05). In this rat abdominal propeller perforator flap model, we found that double perforators without pedicle rotation could support larger flap survival when compared to the single pedicle. However, double perforators did not cause an increase of survival area when pedicles were rotated. In the single-pedicled perforator flap, the flap survival area did not significantly decrease until 180-degree pedicle rotation. In the double-pedicled perforator flap, the flap survival area decreased when the degree of rotation increased. The degenerative changes increased in correlation with the rotation degree in both single- and double-pedicled perforator flaps. © 2014 Wiley Periodicals, Inc. Microsurgery 34:464-469, 2014. © 2014 Wiley Periodicals, Inc.
Say F.,Ondokuz Mayis University |
Coskun S.,Ondokuz Mayis University |
Bulbul M.,Istanbul University |
Alici O.,Samsun Training and Research Hospital
Journal of Pediatric Orthopaedics Part B | Year: 2015
Myositis ossificans is a rarely encountered benign lesion characterized by a non-neoplastic heterotopic bone formation in both soft tissue and skeletal muscle. Three subgroups of myositis ossificans are identified: myositis ossificans progressiva, which is hereditary; nontraumatic or pseudomalignant myositis ossificans, which is developed in the absence of any trauma; and myositis ossificans circumscripta, which is related to evident and direct trauma. In this case report, we present a girl with a swelling on the forearm who was finally diagnosed with nontraumatic myositis ossificans. Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.
Akdeniz E.,Samsun Training and Research Hospital |
Bolat M.S.,Samsun Training and Research Hospital |
Akdeniz S.,Samsun Training and Research Hospital
Journal of Clinical and Analytical Medicine | Year: 2016
Pain is the most complaint symptom of patients in post-operative period. Main causes of post-operative pain are tissue damage, drenaige apparatus and surgical complications due to surgery. Inadequate post-operative pain management may cause increase in morbidity, mortality, hospitalization stay, respiratory and tromboembolic complications, risk of developing chronic pain and decrease in quality of life. Pain management is synonymous with patient comfort. Therefore, clinicians responsible for the treatment of pain manage-ment should have sufficient knowledge and experience. © 2016, Journal of Clinical and Analytical Medicine. All right reserved.