Harison E.,Sami Shamoon College of Engineering
Information and Management | Year: 2010
U.S. legislation provides protection to database contents by intellectual property rights (IPRs) only if "a minimal degree of creativity" was involved in their creation. Although data collection may involve significant investments, factual content is not protected. The goal of the European Database Directive was to guarantee legal provisions for database content and digitized collections. However, the Directive has prompted a public debate about the accessibility to data sets for public use. We reviewed the legal status of database components and assessed the impact of both legislation regimes on a firm's strategies and policies. © 2010 Elsevier B.V. All rights reserved.
Mezhericher M.,Sami Shamoon College of Engineering
European Journal of Pharmaceutics and Biopharmaceutics | Year: 2014
The phenomenon of development of drying-induced stresses has been given a through consideration in the literature on drying of many products. At the same time, to the best of our knowledge, the open published sources contain no information on drying stresses in pharmaceutical granules prepared by continuous manufacturing methods. To study the appearance and evolution of drying-induced stresses in pharmaceutical granules during their production, in this work a theoretical model of drying of single wet pharmaceutical granule has been developed and successively validated by published experimental data obtained on ConsiGma™ continuous from-powder-to-tablet production line (GEA Pharma Systems). The results demonstrate that elevated temperatures of drying air result in faster drying process (which reduces the specific cost of the final product), but, on the other hand, quick drying leads to substantial drying-induced stresses which may damage the granule microstructure, resulting in cracking or even breakage of granules. The drying-induced stresses increase with drying temperature, porosity and size of dense non-hollow granules. The negative effects promoted by the drying-induced stresses should be taken into consideration when choosing operating conditions of continuous production lines including drying of pharmaceutical granules. © 2014 Elsevier B.V. All rights reserved.
Laslo Z.,Sami Shamoon College of Engineering
International Journal of Project Management | Year: 2010
It is well known that the progress of R&D projects has more and more begun to rely on the availability of individual experts who are generally scarce and expensive. The matrix structure considers periodic staffing of project teams which has been found to be efficient for non-scarce human resources but is impractical for individual experts. Our objective is to develop and evaluate an alternative approach for resource planning and scheduling that might be useful for project portfolio management. The method we suggest is an extension of a recently developed optimization model for a job-shop with several machines and chance-constrained deliveries. Our method determines in advance the hiring and releasing points of individual experts that maximize economic gain subject to chance-constrained delivery commitments. For this purpose, we use a simulation based on a greedy priority dispatching rule as well as a cyclic coordinate descent search-algorithm. A benchmarking of the staffing of project teams and the integrative methods shows that integrated planning and scheduling is a very useful tool for the decision-making process in project portfolio management. © 2009 Elsevier Ltd and IPMA.
Bykhovsky D.,Sami Shamoon College of Engineering
Applied Optics | Year: 2015
Free-space optical (FSO) communication may be severely influenced by the inevitable turbulence effect that results in channel gain fluctuations and fading. The objective of this paper is to provide a simple and effective simulator of the weak-turbulence FSO channel that emulates the influence of the temporal covariance effect. Specifically, the proposed model is based on lognormal distributed samples with a corresponding correlation time. The simulator is based on the solution of the first-order stochastic differential equation (SDE). The results of the provided SDE analysis reveal its efficacy for turbulent channel modeling. ©2015 Optical Society of America.
Gera A.E.,Sami Shamoon College of Engineering
International Journal of Reliability, Quality and Safety Engineering | Year: 2013
The recently introduced TSCSTFCF start-up demonstration procedure is generalized to include multi-state tests (success, degradation, failure). The expected number of required tests and the probability of acceptance are evaluated. Comparisons to the previously known multi-state TSCS, CSTF and CSCF procedures, and to the binary TSCSTFCF procedure with i.i.d. tests are provided. A constrained optimization is presented for reducing the expected number of required tests subject to some constraints. Some reduction in the total number of tests is achieved for a correct choice of the relevant design parameters. Also, a procedure for estimating the possibly unknown probabilities of success, degradation and failure is presented using a maximum likelihood technique. Finally, it is pointed out how to extend the analysis for the case of nonidentical units. © 2013 World Scientific Publishing Company.