nter Sami Labs Ltd

Bangalore, India

nter Sami Labs Ltd

Bangalore, India
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Nayak M.,nter Sami Labs Ltd | Nagarajan A.,nter Sami Labs Ltd | Majeed M.,nter Sami Labs Ltd | Majeed M.,Sabinsa Corporation | And 2 more authors.
Natural Product Research | Year: 2017

This study is aimed to isolate the phytoactives from the stem bark of Artocarpus hirsutus and evaluate their in vitro anti-acne activity. The ethanolic stem bark extract of A. hirsutus provided two major phytoactive constituents: (i) pyranocycloartobiloxanthone A, (1) and (ii) Artonine E, (2) whose structures were determined by NMR and MS spectroscopic analysis. The present study is the first to report compound 1 as a mixture of two anomers (α and β), approximately 70:30 ratio. Both compounds 1 and 2 were isolated for the first time from this plant. In vitro anti-acne activity of compounds 1 and 2 were evaluated by agar well diffusion method and the minimum inhibition was determined by broth micro dilution method. The result of anti-microbial activity (MIC = 2.0 μg/mL each) is comparable to antibiotic, Clindamycin (MIC = 0.03 μg/mL) and clearly demonstrate their potential as anti-acne agents. © 2017 Informa UK Limited, trading as Taylor & Francis Group

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