Chapayevsk, Russia

Samara State Medical University

www.samsmu.ru
Chapayevsk, Russia
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Shmygareva A.A.,Orenburg State University | Kurkin V.A.,Samara State Medical University | Sankov A.N.,Orenburg State University
International Journal of Pharmacognosy and Phytochemical Research | Year: 2016

A quantitative analysis method for total anthracenderivatives in rhizomes et radices of Rubia tinctorum with the using of direct spectrophotometry at analytical wavelength 520 nm there was developed. The developed optimal conditions of extraction of anthracenderivatives in rhizomes et radices of Rubia tinctorum L. - extractant is 80% ethyl alcohol; the ratio of "raw-extractant" - 1:30; extraction time -90 min. The relative degree of the determination of the total anthracenderivatives in rhizomes et radices of Rubia tinctorum L. in developed method with confidence probability 0,95 is no more than ±3,18%. The content of total anthracenderivatvies in rhizomata et radices of Rubia tinctorum L. varied from 4,50±0,02% to 4,85±0,03% (calculated on ruberythrinic acid). © 2016, International Journal of Pharmacognosy and Phytochemical Research. All rights reserved.


Shmygareva A.A.,Orenburg State University | Kurkin V.A.,Samara State Medical University | Sankov A.N.,Orenburg State University
International Journal of Pharmacognosy and Phytochemical Research | Year: 2016

A quantitative analysis method for total anthracene derivatives in Rubia Syrup preparation with the using of direct spectrophotometry at analytical wavelength 520 nm there was developed. The technology for producing of Rubia syrup from the decoction of rhizomata et radices of Rubia tinctorum L. in the ratio “the raw material: extract” 1:8 was elaborated. The relative degree of the determination of the total anthracene derivatives in Rubia Syrup in developed method with confidence probability 0,95 is no more than ±4,17%. The content of total anthracene derivatvies in Rubia syrup varied from 0,02±0,001% to 0,025±0,001% (calculated on ruberythrinic acid). © 2016, International Journal of Pharmacognosy and Phytochemical Research. All rights reserved.


Volobuev A.N.,Samara State Medical University
Technical Physics | Year: 2017

The problem of amplifying the signal that ensures the visualization of internal organs in the magnetic resonance tomograph due to the optimal selection of some of its parameters has been considered. The operating principle of the tomograph has been analyzed. The relation between the angle of the magnetic moment precession in hydrogen nuclei in an organism, the frequency of the ac magnetic field exciting this precession, and the constant magnetic field used has been determined using quantum-mechanical concepts. This relation makes it possible to determine the optimal parameters for tomograph operation. © 2017, Pleiades Publishing, Ltd.


Kurkin V.A.,Samara State Medical University | Akushskaya A.S.,Samara State Medical University
Pharmaceutical Chemistry Journal | Year: 2014

The composition and technology of ginseng syrup, a new drug from roots of Panax ginseng C. A. Meyer, were established. Qualitative and quantitative analytical procedures for this preparation used TLC and spectrophotometry with H2SO4 (70%) at analytical wavelength 526 nm. © 2014 Springer Science+Business Media.


Kurkina A.V.,Samara State Medical University
Pharmaceutical Chemistry Journal | Year: 2015

A quantitative determination method for total flavonoids in hawthorn fruit was developed using differential spectrophotometry (analytical wavelength 412 nm) and state standard sample hyperoside and was used to analyze a series of raw material samples. It was shown that the flavonoid content in hawthorn fruit varied in the range 0.112 – 0.183% (calculated as hyperoside). Statistical processing of the test results indicated that the error of a single determination of total flavonoids in hawthorn fruit at 95% confidence probability was ±4.87%. © 2015, Springer Science+Business Media New York.


Kurkina A.V.,Samara State Medical University
Pharmaceutical Chemistry Journal | Year: 2011

A method for assaying total flavonoids in common agrimony (Agrimonia eupatoria L.) herb based on differential spectrophotometry (analytical wavelength 403 nm) and cynaroside State Reference Compound (SRC) was developed. This method was used to analyze a series of raw material samples, which demonstrated that the flavonoid content of common agrimony herb ranged from 1.22% to 1.40% (expressed as cynaroside). Statistical analysis of these experiments showed that the error in single assays of total flavonoids in common agrimony herb was∈±∈4.02% at the 95% confidence level. © 2011 Springer Science+Business Media, Inc.


Davydova M.A.,Samara State Medical University
Voprosy Prakticheskoi Pediatrii | Year: 2017

The review discusses the problems of epidemiology, pathogenesis, diagnosing and treatment of juvenile idiopathic arthritis (JIA) from the positions of destructive lesions of the joints. Structural lesion of a joint has a direct influence on a patient's functional abilities, and progression of roentgenological changes might go on in patients with manifest clinical improvement. As is noted, early assessment of joint destruction is one of key methods for determination of JIA progression and response to basic therapy. Modern evidence of the possibilities of early diagnosis of joint lesions in JIA is presented. The review also evaluates the use of biological agents in paediatric rheumatology. Despite multiple research studies, the problem of risk factors of development of destructive changes in children with JIA still remains unsolved. The problem of objective evaluation of risks for development of joint destruction in different variants of JIA is also disputable.


Gaidel A.V.,Samara State Aerospace University | Pervushkin S.S.,Samara State Medical University
Computer Optics | Year: 2013

In the paper method of the musculoskeletal system osteoporotic diseases computer diagnostics with a help of the femoral neck roentgenograms texture an alysisis proposed and researched. Problem of the texture features providing acceptable recognition quality selection is solved. Method work is researched on the real roentgenograms set with the known diagnoses. Researches results demonstrating a possibility to use proposed method in the clinical practice are adduced. During the work computer program designed both for proposed method research and for clinical diagnostics is developed.


Volobuev A.N.,Samara State Medical University
Technical Physics | Year: 2016

Electrodynamic principles of circular dichroism are developed using a concept of conducting circular structures in matter. A simplified representation of material equations for an optically active medium is obtained in the absence of a transition to the complex domain. A dependence of the absorption coefficient of a circular polarization as a component of the linearly polarized radiation on material parameters is found. Such parameters are analyzed to reveal a possibility of construction of a circular polaroid. © 2016, Pleiades Publishing, Ltd.


Shishkovsky I.,Samara State Medical University | Volchkov S.,Samara State Medical University
Proceedings of SPIE - The International Society for Optical Engineering | Year: 2013

The objective of the investigation was to test the biocompatibility of 3D porous biopolymer matrices (tissue-cellular scaffolds), made of biocompatible and bioresorbable polymers (polycarbonate, polyetheretherketone /PEEK/, polycaprolactone), including the materials with biocompatible oxide ceramics additive (TiO2, Al2O3, ZrO2 and hydroxyapatite) of micron and nano sizes, for tissue-engineering purposes. The porous samples were prepared via a layer-by-layer SLS method. The surface microstructures and their roughness were analyzed by the optical microscopy equipped with the cell analysis software. The cellular morphology, proliferative activity and adhesion of the polymeric and ceramopolymeric matrices were the subjects for comparison. The study showed that all the tested materials posessed biocompatible properties. The experimentally estimated cell duplication speed per day turned out to be maximal for polycarbonate (0.279 duplications per day) and for PEEK + Al2O3 = 3:1 group (0.30 dupl/day) against 0.387 dupl/day for the reference sample and 0.270 dupl/day for the group of cells placed close to the pure titanium samples. © 2013 Copyright SPIE.

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