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Williams P.L.,Harvard University | Korrick S.A.,Harvard University | Sergeyev O.,Samara State Medical University | Revich B.,Russian Academy of Sciences | And 2 more authors.
American Journal of Epidemiology | Year: 2014

Organochlorine pesticides (OCPs) have been linked to adult metabolic disorders; however, few studies have examined these associations in childhood. We prospectively evaluated the associations of baseline serum OCPs (hexachlorobenzene, β-hexachlorocyclohexane, and p,p′-dichlorodiphenyldichloroethylene) in Russian boys with subsequent repeated measurements of serum glucose, insulin, lipids, leptin, and calculated homeostatic model assessment of insulin resistance (IR). During 2003-2005, we enrolled 499 boys aged 8-9 years in a prospective cohort; 318 had baseline serum OCPs and serum biomarkers measured at ages 10-13 years. Multivariable generalized estimating equation and mediation regression models were used to examine associations and direct and indirect (via body mass index (BMI) (weight (kg)/height (m)2)) effects of prepubertal OCP tertiles and quintiles with biomarkers. In multivariable models, higher p,p′-dichlorodiphenyldichloroethylene (quintile 5 vs. quintile 1) was associated with lower leptin, with relative mean decreases of 61.8% (95% confidence interval: 48.4%, 71.7%) in models unadjusted for BMI and 22.2% (95% confidence interval: 7.1%, 34.9%) in models adjusted for BMI; the direct effect of p,p′-dichlorodiphenyldichloroethylene on leptin accounted for 27% of the total effect. IR prevalence was 6.6% at ages 12-13 years. Higher hexachlorobenzene (tertile 3 vs. tertile 1) was associated with higher odds of IR in models adjusted for BMI (odds ratio = 4.37, 95% confidence interval: 1.44, 13.28). These results suggest that childhood OCPs may be associated with IR and lower leptin. © 2014 The Author.


Duplyakov D.,Samara State Medical University | Golovina G.,Medical Center | Lyukshina N.,Childrens Multifield Hospital No 1 | Surkova E.,Samara State Medical University | And 2 more authors.
Seizure | Year: 2014

Episodes of transient loss of consciousness (TLOC) are commonly due to syncope or epileptic seizures. The distinction between both entities on clinical grounds and eyewitness accounts can be challenging and is often hampered by similar clinical features. We briefly summarize syncope-related symptoms and present the case of a female patient who suffered from TLOC episodes due to both reflex syncope and epileptic seizures. Seizure-induced syncope is a rare complication particularly of non-generalized temporal lobe seizures and may be suspected in people with epilepsy who report new semiological features with sudden onset of atonia, TLOC and seizure-related falls. We review epidemiological, clinical and electroencephalographic aspects of seizure-related asystole and syncope and discuss their clinical relevance. The implantation of a cardiac pacemaker appears to efficiently prevent seizure-related falls and consecutive injuries and is an important treatment option if full seizure-control cannot be achieved in these patients. We describe a second case of a patient with refractory temporal lobe epilepsy and seizure-related syncope which ceased after the implantation of a cardiac pacemaker. © 2014 British Epilepsy Association.


Ovchinnikov E.L.,Samara State Medical University | Ivanov V.V.,Samara Engineering College
Journal of Physics: Conference Series | Year: 2011

The methodology of theoretical base of sound dosimetry is offered. The physiological approach to a problem is considered, is constructed bio- and psychophysical model of sound effects on human hearing, and values of comfortable, tolerable and destructive sound pressure and establishment its maximal levels. © 2011 Published under licence by IOP Publishing Ltd.


Gaidel A.V.,Samara State Aerospace University | Pervushkin S.S.,Samara State Medical University
Computer Optics | Year: 2013

In the paper method of the musculoskeletal system osteoporotic diseases computer diagnostics with a help of the femoral neck roentgenograms texture an alysisis proposed and researched. Problem of the texture features providing acceptable recognition quality selection is solved. Method work is researched on the real roentgenograms set with the known diagnoses. Researches results demonstrating a possibility to use proposed method in the clinical practice are adduced. During the work computer program designed both for proposed method research and for clinical diagnostics is developed.


Sazonova O.V.,Samara State Medical University | Baturin A.K.,Russian Academy of Medical Sciences
Voprosy Pitaniia | Year: 2010

The data of the investigation of 340 average income men and women ages 18-60 whose labour is characterized by low power expenditure, are represented in this article. Their food ration contains about 13% of protein and more than 40% of fat, the most part of it contains the saturated fatty acids. 55% of men and 50% of women have got body mass index (BMI) more than 25; obesity is revealed with 7% of men and 18% of women. Glucose blood level is raised at 30% of the surveyed and is correlated with the consumption of the added sugar (r=0,44;p<0,05). The cholesterol maintenance in blood is above normal with 60% of the surveyed, cholesterol connection with the cholesterol food maintenance is not revealed.


Volobuev A.N.,Samara State Medical University
Technical Physics | Year: 2016

Electrodynamic principles of circular dichroism are developed using a concept of conducting circular structures in matter. A simplified representation of material equations for an optically active medium is obtained in the absence of a transition to the complex domain. A dependence of the absorption coefficient of a circular polarization as a component of the linearly polarized radiation on material parameters is found. Such parameters are analyzed to reveal a possibility of construction of a circular polaroid. © 2016, Pleiades Publishing, Ltd.


Anatol'evna R.O.,Samara State Medical University | Veniaminovich F.O.,Samara State Medical University | Mikhaylovich K.S.,Samara State Medical University
Journal of Geriatric Cardiology | Year: 2016

Objective: To identify the factors associated with the development of postoperative atrial fibrillation (POAF) after coronary artery bypass graft (CABG) in elderly patients with coronary artery disease (CAD). Methods: A total of 81 patients with CAD who underwent CABG were enrolled in the study. Patients were divided into two groups: Group 1, without postoperative atrial fibrillation (59 patients, 74.6% men, mean age 65.8 ± 4.0 years); Group 2, with early new-onset atrial fibrillation after CABG (22 patients, 90.9% men, mean age 67.7 ± 5.4 years). Interleukin (IL)-6, IL-8, IL-10, C-reactive protein (CRP), fibrinogen, superoxide dismutase (SOD), N-terminal pro-B-type natriuretic peptide (NT-proBNP), and troponin I were studied. Results: During the observation period, atrial fibrillation occurred in 27.2% cases, an average of 4.9 ± 3.8 days after surgery. In group 2, the left atrium (LA) dimension was larger than in group 1 (43.9 ± 3.4 mm vs. 37.6 ± 3.9 mm, P < 0.001). Patients with POAF had significantly higher IL-6 (72.7 ± 60.8 pg/mL vs. 38.0 ± 34.6 pg/mL, P = 0.04), IL-8 (11.9 ± 6.0 pg/mL vs. 7.7 ± 5.4 pg/mL, P = 0.01) and SOD (2462.0 ± 2029.3 units/g vs. 1515.0 ± 1292.9 units/g, P = 0.04) compared with group without POAF. The multivariate analysis showed that the odds ratio (OR) for POAF development in patients with left atrium more than 39 mm was 2.1 [95% confidence interval (CI): 1.2-3.8, P = 0.0004], IL-6 levels more than 65.18 pg/mL - 1.4 (95% CI: 1.1-2.7, P = 0.009), IL-8 levels more than 9.67 pg/mL - 1.2 (95% CI: 1.1-3.7, P = 0.009), SOD more than 2948 units/g - 1.1 (95% CI: 1.01-2.9, P = 0.04). Conclusions: In our study, the independent predictors of postoperative atrial fibrillation after CABG in elderly patients were left atrium dimension and the increased postoperative concentration of IL-6, IL-8 and superoxide dismutase. ©2016 JGC All rights reserved.


Shishkovsky I.,Samara State Medical University | Volchkov S.,Samara State Medical University
Proceedings of SPIE - The International Society for Optical Engineering | Year: 2013

The objective of the investigation was to test the biocompatibility of 3D porous biopolymer matrices (tissue-cellular scaffolds), made of biocompatible and bioresorbable polymers (polycarbonate, polyetheretherketone /PEEK/, polycaprolactone), including the materials with biocompatible oxide ceramics additive (TiO2, Al2O3, ZrO2 and hydroxyapatite) of micron and nano sizes, for tissue-engineering purposes. The porous samples were prepared via a layer-by-layer SLS method. The surface microstructures and their roughness were analyzed by the optical microscopy equipped with the cell analysis software. The cellular morphology, proliferative activity and adhesion of the polymeric and ceramopolymeric matrices were the subjects for comparison. The study showed that all the tested materials posessed biocompatible properties. The experimentally estimated cell duplication speed per day turned out to be maximal for polycarbonate (0.279 duplications per day) and for PEEK + Al2O3 = 3:1 group (0.30 dupl/day) against 0.387 dupl/day for the reference sample and 0.270 dupl/day for the group of cells placed close to the pure titanium samples. © 2013 Copyright SPIE.


Vachev A.N.,Samara State Medical University
Angiologii{combining double inverted breve}a i sosudistai{combining double inverted breve}a khirurgii{combining double inverted breve}a = Angiology and vascular surgery | Year: 2012

Assessed herein are the results of treating a total of 119 patients presenting with chronic critical ischaemia of the lower extremities accompanied by necrosis of distal portions of the foot. All patients underwent various successful operations of lower-limb revascularization, followed by evaluating the terms of healing of the wounds on the foot after necrectomy and minor amputations. A conclusion was made that after successful limb revascularization for critical ischaemia in patients with atherosclerosis accompanied by coagulative necrosis, performing minor amputations and necrectomies should be delayed.


Pavlichenko A.,Russian National Research Medical University | Smirnova D.,Samara State Medical University
Asian Journal of Psychiatry | Year: 2012

Four influential papers that have appeared recently in the main psychiatric journals from Russia are summarized. The first paper examines socio-demographic profile and clinical manifestations and data of people with mental disorders attending the private psychiatric clinics. It was seen that about 50% of private mental health settings' patients had never consulted a public psychiatric service before seeking help at private psychiatric clinics. Private mental health services have proven their effectiveness in the treatment of non-psychotic disorders and intervention in early onset psychoses. The second paper describes neuropsychological and evolutionary approaches in understanding the comorbidity between depressive and anxiety disorders. It suggests that if anxiety disorder manifests as the first diagnosis, it is more likely that the person will have depression than vice versa. The next article concludes that there is a specific vulnerability of different groups of somatically ill patients to particular mental disorders: cancer is mainly associated with dissociative disorders and asthenia; patients with cardiac disorders are more likely to have comorbid anxiety disorders, hypochondriasis and severe depression. Patients with dermatological illnesses are more likely to have obsessive-compulsive disorder, delusional disorder and mild depression. The last paper discusses some social-psychological and neuro-immunological parameters of people with "dangerous" professions. Using mathematical method, the authors created a model that can decrease the negative influence of work-related extreme factors. © 2012 Elsevier B.V.

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