Sam Higginbottom Institute of Agriculture, Technology and science , formerly Allahabad Agricultural Institute is a government aided deemed university located in Allahabad, India.Established in 1910 by Dr. Sam Higginbottom as Allahabad Agricultural Institute towards improving the economic status of rural population. It became the first institute in India to offer a degree in Agricultural Engineering in 1942.As a tribute to its founder, the institution submitted a proposal to the Ministry of Human Resource Development in 2009 to re-christen Allahabad Agricultural Institute as Sam Higginbottom Institute of Agriculture, Technology and science. The Institute was conferred deemed university status on 15 March 2000 and got certified as a Christian Minority Educational Institution in December 2005. The MHRD has placed SHIATS in the list of elite category 'A' deemed universities on the basis of the expert committee recommendation.The academic infrastructure of the university is organized into eight faculties — which are divided into twenty two constituent schools. It contains a total of seventy eight academic departments and three research centres with emphasis on scientific, agricultural, technological education and research. Since its inception, the institute has produced many notable scientists, geneticists and agricultural engineers. While having completed its own hospital, Hayes Memorial Mission Hospital, the university is in the process of starting a medical college as per Medical Council of India norms. Wikipedia.
Gahoi S.,Sam Higginbottom Institute of Agriculture |
Gautam B.,Sam Higginbottom Institute of Agriculture
Computational Biology and Chemistry | Year: 2017
The root-knot nematode, Meloidogyne incognita causes significant damage to various economically important crops. Infection is associated with secretion of effector proteins into host cytoplasm and interference with host innate immunity. To combat this infection, the identification and functional annotations of Excretory/Secretory (ES) proteins serve as a key to produce durable control measures. The identification of ES proteins through experimental methods are expensive and time consuming while bioinformatics approaches are cost-effective by prioritizing the experimental analysis of potential drug targets for parasitic diseases. In this study, we predicted and functionally annotated the 1889 ES proteins in M. incognita genome using integration of several bioinformatics tools. Of these 1889 ES proteins, 473 (25%) had orthologues in free living nematode Caenorhabditis elegans, 825(67.8%) in parasitic nematodes whereas 561 (29.7%) appeared to be novel and M. incognita specific molecules. Of the C. elegans homologues, 17 ES proteins had “loss of function phenotype” by RNA interference and could represent potential drug targets for parasite intervention and control. We could functionally annotate 429 (22.7%) ES proteins using Gene Ontology (GO) terms, 672 (35.5%) proteins to protein domains and established pathway associations for 223 (11.8%) sequences using Kyoto Encyclopaedia of Genes and Genomes (KEGG). The 162 (8.5%) ES proteins were also mapped to several important plant cell-wall degrading CAZyme families including chitinase, cellulase, xylanase, pectate lyase and endo-β-1,4-xylanase. Our comprehensive analysis of M. incognita secretome provides functional information for further experimental study. © 2017 Elsevier Ltd
Sahu A.K.,Motilal Nehru Medical College |
Singh S.K.,Guru Jambheshwar University of Science and Technology |
Verma A.,Sam Higginbottom Institute of Agriculture
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2011
The present study deals with formulation and evaluation of floating matrix tablets of Chitosan and HPMC using furosemide as model drug. Floating matrix tablets using Chitosan and HPMC in various concentrations were formulated and investigation of in vitro dissolution, floating capability, drug release kinetics and mechanism, similarity factor analysis were performed along with Differential Scanning Calorimetry to determine the physiochemical properties of the prepared tablets and the excipients. Effect of Chitosan and HPMC concentration on drug release kinetics and buoyancy was also determined. Formulations showed 78.53, 63.72, 50.19, 46.67, 74.95 and 76.52% of drug released in 8 hrs respectively. The values of t50% and t80% were found to be between 293.78 to 513.13 minutes for 50% of drug release and 488.72 to 826.69 minutes for 80% of drug release. In vitro drug release of furosemide in all the formulations was best explained by zero order equation and followed mechanism typical of non-Fickian diffusion. Most of the formulations showed floatation lag time of less <1 min and floated throughout the dissolution process. By combining HPMC with Chitosan in various blends we obtained formulations following zero order kinetics with floatation period of more than 8hrs and suitable for oral control release of furosemide.
Pawar K.,CCS Haryana Agricultural University |
Thompkinson D.K.,Sam Higginbottom Institute of Agriculture
Current Research in Nutrition and Food Science | Year: 2017
A dietary supplement containing multifunctional ingredient sources was formulated and optimized for management of diabetes. The formulated dietary supplement comprised of milk fat and groundnut oil (90:10), whey protein concentrate, skim milk powder and sodium caseinate (50:25:25) and resistant starch and maltodextrin (70:30). The feasibility of the formulated dietary supplement in terms of physico-chemical, microbiological and sensory attributes was evaluated during storage period. The formulated supplement was found to have 4.37, 15.93, 10.15, 3.39 and 66.15 percent moisture, protein, fat, ash and carbohydrate respectively. It was observed that there was slight increase in moisture, free fatty acid, thiobarbituric acid and insolubility index while a decrease in dispersibility and sensory attributes (color and appearance, flavor, overall acceptability) during the storage period. However, the dietary supplement stored at room temperature indicated non-significant changes in all physico-chemical, microbiological and sensory parameters throughout the storage period of 180 days. Thus, dietary supplement prepared had better acceptability for a period of six months.
Yadav P.,Sam Higginbottom Institute of Agriculture |
Yadav E.,Sam Higginbottom Institute of Agriculture |
Verma A.,Sam Higginbottom Institute of Agriculture |
Amin S.,Hamdard University
Journal of Pharmaceutical Investigation | Year: 2014
Poor water solubility is one of the reasons for erratic absorption after oral administration of furosemide (FSM), an antihypertensive loop diuretic. Self nano emulsifying drug delivery system (SNEDDS) is a novel drug delivery system utilized to improve the water solubility, permeability and ultimately bioavailability. FSM solubility was determined in various vehicles oils, surfactants and co surfactants. Self emulsification region for the rational design of SNEDDS formulations were identified by pseudoternary diagrams. Developed formulations were characterized by zeta potential determination, droplet size analysis, dilution test, viscosity determination, in vitro dissolution studies and in vivo pharmacodynamic evaluation. A remarkable increase in dissolution was observed for the optimized SNEDDS when compared with the plain FSM and marketed formulation by in vitro dissolution studies. The pharmacological effect of FSM was improved by SNEDDS formulation as compared to plain FSM. The study confirmed that the SNEDDS formulation can be used as a possible alternative to traditional oral formulations of FSM to improve its bioavailability. © 2014, The Korean Society of Pharmaceutical Sciences and Technology.
Sahu A.K.,Shambhunath Institute of Pharmacy |
Verma A.,Sam Higginbottom Institute of Agriculture
Journal of Pharmaceutical Investigation | Year: 2016
The present research was intended to develop a gastroretentive controlled release multiparticulate delivery system for a hypoglycemic drug, metformin hydrochloride (MTF) that could efficiently deliver the drug in active form and also increase its systemic bioavailability. In vitro and in vivo evaluations were performed to determine the efficacy of the formulation. MTF loaded microspheres were prepared by W/O/O double emulsion-solvent evaporation method and optimized by 32full factorial design. The ratio of eudragit RL100 & RS100 (EL:ES) and the chitosan concentration were evaluated as independent variables for dependent variables viz. percent drug release (%DR), percent yield (%Y) and encapsulation efficiency (EE). The morphological characteristics of the microspheres were assessed using scanning electron microscopy which revealed non-aggregated, spherical shape microspheres with rough and rugged surfaces. The particle size range of the formulated microspheres was found to be ~74.77–111.18 µm. In vitro drug release best fitted Korsmeyer Peppas release characteristics with Fickian diffusion release mechanism. The optimized batch F1 demonstrated 84.17 ± 5.80 % drug release, 85.47 ± 0.28 % yield and 70.79 ± 0.67 % EE. Optimized batch performed superior pharmacokinetics with prolonged and increased intensity of hypoglycemic effect (87.68 ± 4.9 %) a relative bioavailability of 154.71 % with respect to the marketed product (56.67 ± 4.7 %). These findings highlight the potential of formulated microparticles as a superior candidate for gastro-retentive sustained release delivery of MTF with respect to marketed product. © 2016, The Korean Society of Pharmaceutical Sciences and Technology.
Faqiri A.,Sam Higginbottom Institute of Agriculture |
Srivastav V.,Sam Higginbottom Institute of Agriculture |
Pandey R.K.,Sam Higginbottom Institute of Agriculture
International Journal of Civil Engineering and Technology | Year: 2017
For public works and building construction projects, concrete is one of the most important materials used. But the use of only fresh concrete is not good for environment and after demolition of the building there are so many wastages collected. So we can use this demolished concrete as recycled concrete for many construction and can save energy, cost and environment too. It means that we have utilized a tremendous amount of recycled concrete and we will have to continue to use it. On the other hand, sustainable development has become more and more important. This paper discusses the effect of recycling method on the different properties of the recycle concrete aggregate and in structural concrete. After the observation of the results it found that when the percentage of the RCA increased from 0% to 100% the compressive strength and tensile strength of the concrete had been decreases while water absorption of the concrete would be increases. © IAEME Publication.
Pawar A.S.,Sam Higginbottom Institute of Agriculture |
Gaikwad A.,Sam Higginbottom Institute of Agriculture
International Journal of Mechanical and Production Engineering Research and Development | Year: 2017
The objective of this study is to develop a new Bio-composite material to fulfil the demand of public & minimize the use of various non-biodegradable materials to save our environment & soil. In future, Bio-composite is going to replace many materials due to its better mechanical properties. In this paper, the focus is on the use of natural and agricultural wastes, which are present in abundance in nature & whose production can also be increased as per the need. In the present study, bio composite materials were developed, in which Natural fibres i.e. Banana, Sisal, and Wheat Straw fibre were used as reinforcing materials with Epoxy resin CY-230 and Hardener HY-951. In this Study, the mechanical properties such as Flexural, Compression and Impact Strengths of the specimens with different composition were tested and compared. Fabrication of different specimens was done by using hand layout technique. Bio-composite samples were developed with different composition of constituents. Mechanical tests were conducted according to ASTM and ISO standards and their properties were analysed. It has been observed that equal weight percentage of Banana & Sisal fibers i.e. specimen E2 possess much better mechanical properties. © TJPRC Pvt. Ltd.
Jaiswal N.,Sam Higginbottom Institute of Agriculture |
Verma Y.,Sam Higginbottom Institute of Agriculture |
Misra P.,Sam Higginbottom Institute of Agriculture
In Vitro Cellular and Developmental Biology - Plant | Year: 2017
The Glycyrrhiza genus, in the Fabaceae family, includes numerous medicinal and edible herbs that contain a wide range of phytochemicals which are used pharmaceutically and commercially. Glycyrrhiza spp. are under the threat of overexploitation and depletion; therefore, there is an urgent need for conservation. It is advantageous to develop in vitro techniques not only for propagation, multiplication and preservation but also for elicitation of secondary metabolite production. This review provides information on the micropropagation of different Glycyrrhiza spp. related to the use of different explants, the combination of plant growth regulators with different sterilization strategies, the culture conditions and additional factors influencing in vitro propagation (such as light, temperature, humidity and pH). Enhanced production of bioactive secondary metabolites by different elicitors is discussed. Different strategies for conservation of germplasm from Glycyrrhiza spp., namely encapsulation, cryopreservation and slow-growth system, are deliberated. The storage and availability of germplasm for commercial cultivation over the long run along with their germplasm evaluation using random amplification of polymorphic DNA and inter-simple sequence repeat techniques have also been presented. Successful multiplication, elicitation and downstream processing will lead to the production of not only greater quantities of planting material with improved quality but also commercially desired metabolites. The production of clinically novel compounds through biotransformation by cultured Glycyrrhiza spp. cells which can be used in future studies on somaclonal variation, genetic transformation and drug discovery is also reviewed. © 2017 The Society for In Vitro Biology
Borges V.,Sam Higginbottom Institute of Agriculture |
Jeberson W.,Sam Higginbottom Institute of Agriculture
Smart Innovation, Systems and Technologies | Year: 2016
Activity Recognition is a complex task of the Human Computer Interaction (HCI) domain. k-Nearest Neighbors (kNN) a non-parametric classifier, mimics human decision making, using experiences for segregating a new object. Fuzzy Logic mimics human intelligence to make decisions; but suffers from requiring domain expertise to propose novel rules. In this paper a novel technique is proposed that comes with efficient fuzzy rules from the training data. The kNN classifier is modified by incorporating fuzzification of the feature space by learning from the data and not relying solely on domain experts to draw fuzzy rules. Additional novelty is the efficient use of the Fuzzy Similarity Relations and Fuzzy Implicators for hybridization of the kNN Classifier. The proposed hybridized fuzzy kNN classifier is shown to perform 5.6 % better than the classical kNN counterpart. © Springer India 2016.
Verma A.,Sam Higginbottom Institute of Agriculture
Medicinal Chemistry Research | Year: 2012
Chitosan (CH)-based ciprofloxacin (CFX) prodrug conjugate have been successfully synthesized using isopropyl alcohol/water and glacial acetic acid mixture and the film was made by solution casting method. The FTIR spectrum result showed that CH-CFX complex exhibit an electrostatic interaction between NH 2 group of CH and COO - group of CFX. The physical parameters were analyzed by X-ray diffraction pattern and morphology by scanning electron microscopy. Thermal behavior of the films was analyzed by differential scanning calorimetry. The antimicrobial activity of the complexes against various Gram-positive bacteria (Staphylococcus aureus, Bacillus subtilis) and Gram-negative bacteria (Escherichia coli, Pseudomona. aeruginosa) was evaluated and found that the antibacterial activity of CH-CFX complex was greater than that of parent drug CFX. This may be due to the favorable pharmacokinetics, pharmacodynamics, excellent bacterial susceptibility and good stability of the drug conjugate. © 2012 Springer Science+Business Media, LLC.