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Srinivasan N.,University of Oklahoma | Oswal A.,University of Oklahoma | Garg S.,University of Oklahoma | Nahar J.,University of Oklahoma | And 2 more authors.
American Journal of the Medical Sciences | Year: 2010

Systemic lupus erythematosus (SLE) is a well-known autoimmune chronic inflammatory disease, which can virtually affect any organ system in the body. Although hemolytic anemia has been known to occur in <10% of SLE patients, they are usually mediated through warm antibodies. It is extremely rare to see cold antibody-mediated hemolytic anemia in SLE, and only few cases have been reported in literature to our knowledge. This is a unique case report of SLE associated with cold agglutinin hemolytic anemia in a patient presented with generalized tender lymphadenopathy and typical B-symptoms including fever, night sweats, and significant weight loss. © Copyright 2010 Southern Society for Clinical Investigation.

Raghvendra G.,Nkp Salve Institute Of Medical Science And Research Center | Vishwamohan U.,Government Arts and Commerce College
Research Journal of Chemistry and Environment | Year: 2011

With the ever growing concerns of new HIV infections around the world, despite the best possible comprehensive resource mobilization, it is desired to develop microbicides for vaginal and anal applications to prevent the transmission of HIV virus especially among the most vulnerable women usually devoid of their sexual and reproductive rights. Researches need to focus on the costing, availability, accessibility, applicability, efficiency and effectiveness of the microbicides to be used across strata of extremely different socio cultural dimensions, individual practices, preferences and habits. Therefore, the challenges continue to be addressed with initial reports and history of observed failures. The golden edge visible for success of various other microbicides shows the path of success towards reaching a consensus for scientifically developed microbicides and their use after all the phases of trials are over. However, queries related to the highly potent drugs and their limited usefulness need to be resolved by the careful and cautious application of mind by the drug control authorities and related drug distribution systems across nations. The overall and comparative assessment of the drugs being tested as microbicides along with the experiences gained in the field will clarify the scenario for further subsequent actions at the levels of policy makers, implementers and interventionists.

Chimne H.D.,Nkp Salve Institute Of Medical Science And Research Center | Ksheersagar D.D.,Nkp Salve Institute Of Medical Science And Research Center
Journal of the Anatomical Society of India | Year: 2012

Dermatoglyphics is the scientific study of epidermal ridges and their configurations on the palmar region of hand and fingers and plantar region of foot and toes. Against the genetic background of dermatoglyphic patterns and coronary artery disease, the study was undertaken to determine the correlation between them. The present study includes 150 cases of angiographically proven coronary artery disease (CAD) and 150 cases of healthy normal individuals. The palmar prints of both hands were taken on white paper by Ink method as described by Cummins and Midlo. It is noted that there is significant decrease in loops with corresponding increase in whorls in males, (M+F) combined series and left hand of CAD patients. The true palmar pattern is significantly decreased in thenar area in females; third interdigital area in (M+F) combined series and right hand; and fourth interdigital area in left hand of CAD patients. There is significant increase in '4' palmar triradii in males, (M+F) combined series and right hand; and '5' palmar triradii in females with significant decrease in '6' palmar triradii in both sexes and both hands of CAD patients. The mean value of atd angle is significantly increased in males, (M+F) combined series and left hand of CAD patients as compared to the controls. There is no significant correlation in ab ridge count and CAD. © 2012 Anatomical Society of India.

Sagdeo M.M.,Nkp Salve Institute Of Medical Science And Research Center | Arora D.,Nkp Salve Institute Of Medical Science And Research Center
JK Science | Year: 2011

The present study was carried out on 500 females in the age group of 40-60yrs to find out average age of menopause in rural and urban women and associated menopausal symptoms & its awareness & prevalence by predesigned questionnaire. We found out that, the percentage of all menopausal symptoms is more in urban women as compared to rural cases. Commonly observed symptoms' are hot flushes, joint & muscular discomfort and physical & mental exhaustion. However women don't come out with sexual problem much both in rural and urban.The symptoms are at peak during 45-55 years and after 55 years severity decreases. However the urinary symptoms and heart discomfort are more in > 55 years in urban women. Though the urban women are consulting physician for menopausal problems still percentage is very less. On the other hand rural women don't come out with their problems.

Dhoble C.,Nkp Salve Institute Of Medical Science And Research Center | Saoji N.,Nkp Salve Institute Of Medical Science And Research Center | Jeswani J.,Nkp Salve Institute Of Medical Science And Research Center | Rios R.,National Autonomous University of Nicaragua, Managua
American Journal of Case Reports | Year: 2015

Objective: Unusual clinical course Background: Hepatopulmonary syndrome (HPS) is a pulmonary complication characterized by a triad of chronic liver disease, arterial hypoxemia, and pulmonary vascular dilations. Agitated saline contrast echocardiography is a simple inexpensive criterion standard procedure for confirming the diagnosis of HPS. Case Report: Here, we discuss a case of a 45-year-old male Indian patient with no medical history who presented to our hospital with exertional dyspnea, hypoxia, and classical signs of HPS. A diagnosis of cirrhosis was made on the basis of history, liver enzymes, and ultrasound, while HPS was diagnosed using transthoracic echocardiography with agitated saline. Conclusions: HPS, although a complication of cirrhosis, can be the initial presentation in undiagnosed cirrhotic patients. Thus, it is important to include HPS in differentials when dealing with cases of progressive dyspnea. Also, the possibility of a liver disease etiology should be explored in patients with unexplained hypoxemia. © Am J Case Rep, 2015.

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