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Majāz al Bāb, Tunisia

Douik H.,Salah Azaiz Institute of Cancer | Attia Romdhane N.,University of Sfax | Guemira F.,Salah Azaiz Institute of Cancer
Pathology Research and Practice | Year: 2016

Background: Nasopharyngeal carcinoma (NPC) is a particular entity of head neck cancer, tightly related to Epstein-Barr virus infection and thus to HLA genes. In this study, we aimed to analyze HLA-E polymorphism in NPC advent and prognosis.130 unrelated patients with CNP and 180 unrelated and healthy controls were included in our study. HLA-E genotyping was performed by PCR/RFLP method; SPSS (13.0) was used for statistical analysis, and survival curbs were established with the "Kaplan-Meier" method (Log Rank. <. 0.05). Results: We found a significant difference within HLA-E*103 variants between patients and controls: E*1031 and E*1032 were associated with CNP (OR=1.613, p =0.013 and OR=1.0809, p =0.055), and E*1033 with controls (OR=0.254, p <10-4). Conclusion: Our study reveals that HLA-E polymorphism is associated with nasopharyngeal cancer. HLA-E expression studies could be used to understand the implication of E*103 variants. © 2016 Elsevier GmbH. Source


Ben Chaaben A.,Salah Azaiz Institute of Cancer | Ben Chaaben A.,French Institute of Health and Medical Research | Ben Chaaben A.,University of Tunis | Busson M.,French Institute of Health and Medical Research | And 12 more authors.
Tissue Antigens | Year: 2011

The interleukin 12 (IL-12) cytokine, encoded by polymorphic genes, plays a central role in the T helper 1 cell-mediated immunity against tumors. We investigated whether the 3' untranslated region +1188 A/C polymorphism (rs 3212227) influences the nasopharyngeal carcinoma (NPC) risk in Tunisian patients. DNA analysis of 247 patients and 284 healthy individuals showed a higher frequency of the 1188 C allele and the CC genotype in patients than in controls (P = 0.00001and P = 0.00005) suggesting that the C variant allele is associated with the susceptibility to NPC. Additional testing showed that the homozygous CC genotype is also associated with advanced stage of the tumor extension at presentation (P = 0.022). Our data suggest that the impaired production of IL-12 behaves as a risk factor for NPC occurrence and progression. © 2011 John Wiley & Sons A/S. Source


Ben Chaaben A.,Salah Azaiz Institute of Cancer | Ben Chaaben A.,French Institute of Health and Medical Research | Ben Chaaben A.,University of Tunis | Mariaselvam C.,French Institute of Health and Medical Research | And 16 more authors.
Immunobiology | Year: 2015

Nasopharyngeal carcinoma (NPC) is a complex multifactorial disorder involving both genetic and environmental factors. Polymorphisms of genes encoding nitric oxide synthase (NOS) and antioxidant glutathione-S transferases (GSTs) have been associated with various tumors. We examined the combined role of NOS3, NOS2 and GST polymorphisms in NPC risk in Tunisians. We found that NOS3-786C allele and -786 CC genotype, NOS3+894T allele and +894 GT+TT genotypes, NOS2-277 G allele and -277 GG genotype, and GSTT1 del/del genotype, are more prevalent in NPC patients as compared to healthy controls. Our results suggest that genetically driven dysfunction in red-ox stress pathway could augment the risk in NPC-susceptible individuals. © 2014 Elsevier GmbH. Source


Ben Chaaben A.,Salah Azaiz Institute of Cancer | Mariaselvam C.,Salah Azaiz Institute of Cancer | Salah S.,Salah Azaiz Institute of Cancer | Busson M.,Salah Azaiz Institute of Cancer | And 15 more authors.
Immunobiology | Year: 2015

Nasopharyngeal carcinoma (NPC) is a complex multifactorial disorder involving both genetic and environmental factors. Polymorphisms of genes encoding nitric oxide synthase (NOS) and antioxidant glutathione-S transferases (GSTs) have been associated with various tumors. We examined the combined role of NOS3, NOS2 and GST polymorphisms in NPC risk in Tunisians. We found that NOS3−786C allele and −786 CC genotype, NOS3+894T allele and +894 GT+TT genotypes, NOS2−277 G allele and −277 GG genotype, and GSTT1 del/del genotype, are more prevalent in NPC patients as compared to healthy controls. Our results suggest that genetically driven dysfunction in red–ox stress pathway could augment the risk in NPC-susceptible individuals. Source

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