Sakihai Institute

Gifu-shi, Japan

Sakihai Institute

Gifu-shi, Japan

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Nagata C.,Gifu University | Wada K.,Gifu University | Nakamura K.,Gifu University | Tamai Y.,Gifu University | And 3 more authors.
Menopause | Year: 2012

OBJECTIVE: Prospective studies on physical activity and diet and the onset of natural menopause are scarce. The aim of this study was to examine the association of physical activity and dietary factors potentially related to endogenous estrogen levels such as fats, dietary fiber, soy isoflavones, and alcohol with the onset of menopause in a cohort of premenopausal women. METHODS: Study participants were 3,115 premenopausal Japanese women aged 35 to 56 years derived from the participants in the Takayama Study. Physical activity was assessed by a validated questionnaire at baseline, and the metabolic equivalent score was calculated. The dietary intakes were estimated by a validated food frequency questionnaire at baseline and adjusted for total energy. Menopause status was defined as the absence of menstruation for 12 months or more. The Cox proportional hazard model was used to estimate the hazard ratio of the occurrence of menopause after controlling for age, parity, body mass index, smoking status, years of education, and lifelong irregular menstrual cycle. RESULTS: During the 10-year follow-up, 1,790 women experienced natural menopause. A high physical activity level and a high intake of polyunsaturated fat were moderately but significantly associated with the earlier onset of menopause; the hazard ratios for the highest versus lowest quartile were 1.17 (95% CI, 1.02-1.34) for physical activity and 1.15 (95% CI, 1.01-1.31) for polyunsaturated fat intake. Total fat, other types of fat, dietary fiber, soy isoflavones, and alcohol were not associated with the onset of menopause. CONCLUSIONS: These data suggest that high levels of physical activity and polyunsaturated fat intake are associated with earlier onset of menopause.


Oba S.,Gifu University | Nagata C.,Gifu University | Nakamura K.,Gifu University | Fujii K.,Gifu University | And 4 more authors.
Metabolism: Clinical and Experimental | Year: 2010

We assessed the relationship of the dietary glycemic index (GI), glycemic load (GL), and intake of carbohydrate and rice, and risk of mortality from stroke and its subtypes. The cohort consisted of 12561 men and 15 301 women residing in Takayama, Japan, in 1992. At the baseline, a food frequency questionnaire was administered; and the dietary GI, GL, and intake of carbohydrates and rice were estimated. Deaths from stroke occurring in the cohort were prospectively noted until 1999 with data from the office of the National Vital Statistics. The risk of mortality from stroke was assessed with a Cox proportional hazard model after adjusting for age; body mass index; smoking status; physical activity; history of hypertension; education; and intake of total energy, alcohol, dietary fiber, salt, and total fat. The risk of stroke subtypes was assessed in the age-adjusted model. The hazard ratios of total stroke comparing the highest vs the lowest quartiles of the dietary GI were 0.78 (95% confidence interval [CI], 0.41-1.47) with P trend = .50 in men and 2.09 (95% CI, 1.01-4.31) with P trend = .10 in women. Among women, the association was also significant with the risk of ischemic stroke (hazard ratio = 2.45; 95% CI, 1.01-5.92; P trend = .03); and a significant positive trend was also observed between dietary GL and mortality from hemorrhagic stroke (P trend = .05). The current study implies that diets with a high dietary GI increase the risk of mortality from stroke among Japanese women. © 2010 Elsevier Inc.


Oba S.,Gifu University | Nagata C.,Gifu University | Nakamura K.,Gifu University | Fujii K.,Gifu University | And 4 more authors.
British Journal of Nutrition | Year: 2010

Although the inverse association between coffee consumption and risk of diabetes has been reported numerous times, the role of caffeine intake in this association has remained unclear. We evaluated the consumption of coffee and other beverages and food containing caffeine in relation to the incidence of diabetes. The study participants were 5897 men and 7643 women in a community-based cohort in Takayama, Japan. Consumption of coffee, green tea, oolong tea, black tea and chocolate snacks were measured with a semi-quantitative FFQ in 1992. At the follow-up survey in 2002, the development of diabetes and the time of diagnosis were reported. To assess the association, age, smoking status, BMI, physical activity, education in years, alcohol consumption, total energy intake, fat intake and women's menopausal status were adjusted. Among men who consumed one cup per month to six cups per week and among those who consumed one cup per d or more, the associated hazard ratios were 069 (95% CI 050, 097) and 069 (95% CI 049, 098) compared with those who drank little to no coffee, with a P value for trend of 032. The hazard ratios for women with the same coffee consumption patterns were 108 (95% CI 074, 160) and 070 (95% CI 044, 112), with a P value for trend of 003. The association between estimated total caffeine intake and risk of diabetes was insignificant both among men and among women. The results imply that coffee consumption decreased the risk of developing diabetes. The protective effect may exist aside from the influence of caffeine intake.


Wada K.,Gifu University | Nagata C.,Gifu University | Nakamura K.,Gifu University | Iwasa S.,Iwasa Maternity | And 3 more authors.
Endocrine Journal | Year: 2012

The association between light exposure at night and sex hormone levels in utero has scarcely reported. We assessed the associations between sleep duration or being awake in the late evening hours, which can be as indicator of light exposure at night, and the maternal and umbilical blood hormone levels during pregnancy and at delivery among Japanese women. The data for 236 women and their newborns who visited a maternal clinic in Gifu, Japan, between May 2000 and October 2001 were analyzed. Maternal blood samples were obtained at approximately the 10th weeks, 29th weeks of gestation, and at delivery. Umbilical cord artery blood was immediately drawn after birth. Information for sleep during pregnancy was obtained by a self-administered questionnaire. The levels of estradiol and testosterone were measured using radioimmunoassay. Maternal serum testosterone level in the 10th week was higher among those who were awake at or after 1:00 a.m. than among those who were asleep at that time (P = 0.032). Maternal estradiol level in the 29th week was inversely associated with sleep duration on weekends (P = 0.043). Umbilical testosterone level at delivery inversely correlated with sleep duration on weekdays (P = 0.030). These associations were somewhat stronger among mothers with female offspring than those with male offspring. These results suggested that exposure to light at night might increase sex hormone levels during pregnancy. © The Japan Endocrine Society.


Nakamura K.,Gifu University | Nagata C.,Gifu University | Wada K.,Gifu University | Tamai Y.,Gifu University | And 3 more authors.
Japanese Journal of Clinical Oncology | Year: 2011

Objective: To examine the association of smoking and lifestyle factors with pancreatic cancer death in the prospective design. Methods: Mortality from pancreatic cancer in regard to smoking, body mass index, physical activity, and alcohol, coffee and green tea intake, was studied in a prospective cohort of 30 826 inhabitants in Takayama, Japan. In 1992, each subject completed a self-administered questionnaire on demographic information, smoking, drinking habits, diet, exercise and medical histories. The response rate was 85.3%. Results: From 1992 to 1999, 33 men and 19 women died due to pancreatic cancer. Hazard ratios and 95% confidence intervals were determined using Cox proportional hazards models. Women who were defined as current smokers at baseline had significant and increased risk of pancreatic cancer death after adjustment for age, body mass index and history of diabetes mellitus (Hazard ratio:4.77, 95% confidence intervals:1.58-14.4). There were significant positive associations of pancreatic cancer death with the years of smoking and the number of cigarettes consumed daily in women in a dose-dependent manner. Current smokers indicated a non-significant risk increase in men (Hazard ratio: 3.81, 95% confidence intervals: 0.88-16.6). Body mass index, physical activity, and alcohol, coffee and green tea intake were not significantly associated with pancreatic cancer death. Conclusions: These data suggested that smoking increases the risk of death from pancreatic cancer in Japanese women. © The Author (2010). Published by Oxford University Press. All rights reserved.


Fujii K.,Gifu University | Nagata C.,Gifu University | Nakamura K.,Gifu University | Kawachi T.,Gifu University | And 4 more authors.
Journal of Epidemiology | Year: 2011

Background: Several studies have reported the prevalence of tinnitus among general populations; however, most of these studies were conducted in Europe or the United States. We estimated the prevalence of tinnitus among the general adult population in Japan. Methods: The subjects were participants in the Takayama Study, a population-based cohort study. In 2002, a total of 14 423 adults (6450 men and 7973 women) aged 45 to 79 years responded to a self-administered questionnaire that inquired about history of tinnitus, which was defined as episodes lasting longer than 5 minutes, excluding those occurring immediately after noise exposure. Respondents were also asked about the loudness and severity of tinnitus. Results: Overall, 11.9% of the subjects reported having tinnitus; the percentage was somewhat higher among men (13.2%) than women (10.8%). The prevalence of tinnitus increased with age in both sexes. Approximately 0.4% of the overall population reported that tinnitus had a severe effect on their ability to lead a normal life. Medical history of hypertension or ischemic heart diseases, use of steroid or antihypertensive medication, and employment as a factory worker or machine operator were associated with tinnitus status in both men and women. Conclusions: Tinnitus is relatively common in Japan. Although the use of various definitions of tinnitus in different studies makes it difficult to compare prevalence among populations, the present prevalence estimate was similar to those in studies in Europe and the United States. © 2011 by the Japan Epidemiological Association.

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