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Hen Y.,Sakakibara Heart Institute Clinic | Iguchi N.,Sakakibara Heart Institute Hospital | Takada K.,Sakakibara Heart Institute Hospital | Utanohara Y.,Sakakibara Heart Institute Hospital | And 9 more authors.
Respiration and Circulation | Year: 2011

We examined the relationship between late gadolinium enhancement (LGE) findings on cardiac MRI and the reverse remodeling effect of Carvedilol. Fifty-six patients with left ventricular ejection fraction (EF) of less than 50% and no significant stenotic lesion on coronary angiography were studied. Cardiac MRI was conducted before Carvedilol administration, and ultrasonography was conducted both before and 3 months after administration. Heart rate decreased significantly (p<0.0001) from 80.9±19.6/min before administration to 69.1±11.0/min after administration. The patients were stratified into LGE-negative, low-LGE, and high-LGE groups from pre-treatment MRI findings. The change (post-treatment - pre-treatment values) in the end-diastole volume index (ΔEDVI), change in end-systole volume index (ΔESVI), and change in EF (ΔEF) were compared among these three groups. ΔEDVI (ml/m 2) was -31.0±32.7 in the LGE-negative group, -24.0±21.7 in the low-LGE group and -3.3±24.2 in the high-LGE group. ΔESVI (ml/m 2) was -31.0±27.5 in the LGE-negative group, -30.7±18.8 in the low-LGE group. and -7.0±20.1 in the high-LGE group. ΔEF(%) was 13.5±11.6 in the LGE-negative group, 18.3±9.6 in the low-LGE group, and 5.7±8.1 in the high-LGE group. Significant differences were observed between groups for all three parameters. The reverse remodeling effect as a result of Carvedilol administration differed depending on the percentage of LGE findings in the left ventricle. Source

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