Saitama, Japan
Saitama, Japan

Saitama University is a Japanese national university located in a suburban area of Sakura-ku, Saitama City capital of Saitama Prefecture in Tokyo Metropolitan Area.The University has five faculties for undergraduate education -Liberal Arts, Education, Economics, Science, and Engineering- and four graduate schools -Cultural Science, Education, Economic Science, and Science and Engineering-, all offering programs leading to doctorates as well as master’s degrees. The total enrollment in the university is more than 8,500 with more than 500 overseas students pursuing undergraduate and postgraduate studies . Wikipedia.


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Patent
Yokohama City University and Saitama University | Date: 2015-02-26

The present invention finds out find out the requirements necessary for preparing a cell condensate in vitro from a large number of cells (several ten thousand to several million cells) and provides a method of forming a cell condensate for self-organization which is capable of realizing complex higher structures (such as liver and kidney) and interactions with other organs. A method of preparing a cell condensate in vitro, comprising culturing a mixture of cells and/or tissues of a desired type in a total cell count of 400,000 or more and 100,000 to 400,000 mesenchymal cells to form a cell condensate of 1 mm or more in size. A cell condensate prepared by the above-described method. A method of preparing a three-dimensional tissue structure, comprising allowing self-organization of a cell condensate prepared by the above-described method to form a three-dimensional tissue structure that has been provided with higher structures. A gel-like support wherein the side on which culture is to be performed has a U- or V-shaped cross-section.


Patent
Saitama University | Date: 2015-02-23

A magnetic levitation device includes a pair of magnets, a displacement detection means, and a control means. The pair of magnets generate magnetic force for supporting a ferromagnet in a noncontact manner. The displacement detection means detect the displacement of the ferromagnet in a lateral shift direction. The control means suppresses the vibration of the ferromagnet in a lateral shift direction. The control means controls the pair of magnets so that a stronger magnetic force acts on the ferromagnet that is displaced in a direction departing from the center of the vibration than when the ferromagnet is displaced in a direction returning to the center of the vibration.


Patent
Yokohama City University and Saitama University | Date: 2017-02-01

The present invention finds out find out the requirements necessary for preparing a cell condensate in vitro from a large number of cells (several ten thousand to several million cells) and provides a method of forming a cell condensate for self-organization which is capable of realizing complex higher structures (such as liver and kidney) and interactions with other organs. A method of preparing a cell condensate in vitro, comprising culturing a mixture of cells and/or tissues of a desired type in a total cell count of 400,000 or more and 100,000 to 400,000 mesenchymal cells to form a cell condensate of 1 mm or more in size. A cell condensate prepared by the above-described method. A method of preparing a three-dimensional tissue structure, comprising allowing self-organization of a cell condensate prepared by the above-described method to form a three-dimensional tissue structure that has been provided with higher structures. A gel-like support wherein the side on which culture is to be performed has a U- or V-shaped cross-section.


Patent
Saitama University | Date: 2017-03-29

A magnetic levitation device includes a pair of magnets, a displacement detection means, and a control means. The pair of magnets generate magnetic force for supporting a ferromagnet in a noncontact manner. The displacement detection means detect the displacement of the ferromagnet in a lateral shift direction. The control means suppresses the vibration of the ferromagnet in a lateral shift direction. The control means controls the pair of magnets so that a stronger magnetic force acts on the ferromagnet that is displaced in a direction departing from the center of the vibration than when the ferromagnet is displaced in a direction returning to the center of the vibration.


Patent
Zeria Pharmaceutical Co. and Saitama University | Date: 2016-02-03

To provide a therapeutic agent for gastrointestinal disorder such as diabetic gastroparesis. A postprandial gastrokinetic agent containing (A) ghrelin or a ghrelin agonist and (B) motilin or a motilin agonist as active ingredients, in which both the ingredients (A) and (B) are administered so as to act on the stomach after food intake.


The aromatic compounds have for a long time played important roles in organic chemistry. The skeletons of most aromatic compounds consist mainly of carbon atoms and other second-row elements. However, a recent question is whether the concept of aromaticity can be applied when the carbon atoms of the π-frameworks are substituted by heavier group 14 atoms. In contrast to recent extensive works on the creation of silicon- and germanium-containing carbocyclic π-frameworks, which demonstrated novel heavier aromatic compounds, no one knew whether or not the concept of aromaticity could be applied to tin-containing carbocyclic compounds in 2001. We therefore targeted the synthesis of a dilithiostannole, which is a tin-analog of the cyclopentadienyl anion. Dilithiostannoles and its benzannulated derivatives were successfully synthesized by reduction of the corresponding 1,1-diphenyl derivatives. X-ray diffraction analysis of the dilithiostannoles revealed that each of the stannole rings is almost planar without bond alternation of the C-C bonds. Based on their structural features and very negative nucleus-independent chemical shift (NICS) values calculated at 1.0. Å above the rings, the dilithiostannoles were concluded to be the first tin-containing carbocyclic aromatic compounds. In the benzannulated derivatives, each of the stannole rings is more aromatic than its adjacent benzene ring, as determined by theoretical calculations. The synthesis of dilithioplumbole was also accomplished and it was concluded to have considerable aromatic character, as supported by X-ray diffraction analysis and theoretical calculations. Therefore, the concept of aromaticity is now extended to lead-containing carbocyclic compounds. The reactivity of the dilithio-stannoles and -plumbole is also demonstrated. © 2011 Elsevier B.V.


Patent
Saitama University | Date: 2016-04-13

Provided are a new peptide, a vector inserting a DNA that codes said peptide, a transformant obtained by transformation with that vector, and applications of said peptide, vector and transformant. The peptide according to the present invention comprises an amino acid sequence set forth in SEQ ID NO: 1, or an amino acid sequence obtained by substituting, deleting or adding one or more amino acids to/from the amino acid sequence set forth in SEQ ID NO: 1. This peptide and the vector inserting a DNA that codes this peptide are suitable for use in an agent for promoting the proliferation of pancreatic hormone-producing cells, or a differentiation induction promoter that induces differentiation to pancreatic hormone-producing cells.


Patent
Saitama University | Date: 2015-01-07

A measurement device includes: a light source section (10) that generates a pump beam (P) and a Stokes beam (S); a pulse stretch section (30) that stretches the pulse of the pump beam (P) so that the pulse width of the Stokes beam (S) is shorter than the pulse width of the pump beam (P); an optical splitter section (41) that splits the Stokes beam (S) into two beams; an optical scan section (50) that scans a subject (S) with the pulse-stretched pump beam (P) and one (S_(M)) of the two beams split by the optical splitter section (41); a first optical detection section (70) that detects an anti-Stokes beam (AS) from the subject (S); a second optical detection section (80) that detects an interference beam of the other (S_(S)) of the two beams and the Stokes beam (S_(M)) reflected by the subject (S); and a signal processing section (90) that performs an image generation process based on a detection signal from the first optical detection section (70) and a detection signal from the second optical detection section (80).


The purpose of the present invention is to provide an evaluation method and evaluation kit for evaluating the risk of onset of diffuse alveolar damage due to such factors as anticancer drug administration. The purpose of the present invention is also to provide a method for evaluating the risk of onset of side effects in anticancer drug treatment. An evaluation method and evaluation kit for evaluating the risk of onset of diffuse alveolar damage, including detecting gene polymorphism present in the MUC4 gene. A method for evaluating the risk of onset of side effects in anticancer drug treatment, including detecting gene polymorphism present in the MUC4 gene of a patient scheduled for anticancer drug administration.


Patent
Ochanomizu University and Saitama University | Date: 2015-12-02

It is an object of the present invention to provide a novel therapeutic agent for demyelinating disease which has an action to suppress demyelination of nerve axons. According to the present invention, a therapeutic agent for demyelinating disease which comprises cyclic phosphatidic acids, carba-cyclic phosphatidic acids, thia-cyclic phosphatidic acids, or a salt thereof is provided.

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