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Suzuki M.,University of Tokyo | Liu M.,University of Tokyo | Kurosaki T.,Social Insurance Saitama Hospital | Suzuki M.,Sakuragicho Ocean Clinic | And 12 more authors.
Clinical Genitourinary Cancer | Year: 2011

Background: Genome-wide association studies have revealed several genetic variants at 8q24 that are associated with prostate cancer susceptibility. Rs6983561 (A/C) is a single-nucleotide polymorphism located at 8q24 that has been established as a genetic risk marker for prostate cancer susceptibility. The present study investigated the association between the rs6983561 polymorphism and prostate cancer mortality in a Japanese population. Patients and Methods: The study examined 518 native Japanese male patients with sporadic prostate cancer. Germline DNA samples were obtained from all participants and genotyping of rs6983561was performed using a TaqMan assay. Observation periods were from the date of diagnosis of prostate cancer to May 21, 2010. The Cox proportional hazards model was used to estimate the cause-specific survival (CSS) and the overall survival (OS). Results: Patients with the CA/CC genotype of rs6983561 survived significantly longer than those with the AA genotype. In a multivariate model, the hazard ratios (HRs) and 95% confidence intervals (CIs) of the CSS and the OS for the rs6983561 polymorphism were 2.438 (1.262 5.046, P =.007) and 1.957 (1.142 3.485, P =.014), respectively. When the analysis was restricted to subjects with metastatic disease, the HRs of the CSS and the OS were 3.353 (95% CI, 1.689 7.446; P = 3.76 x 10 -4) and 3.361 (95% CI, 1.741 7.136; P = 1.70 x 10 -4), respectively. Conclusion: In the Japanese population examined in this study, the rs6983561 polymorphism at 8q24 was significantly associated with prostate cancer mortality, especially among patients with metastatic disease. © 2011 Published by Elsevier Inc.


Hosokawa T.,Social Insurance Saitama Hospital | Sato Y.,Social Insurance Saitama Hospital | Seki T.,Social Insurance Saitama Hospital | Maebara M.,Social Insurance Saitama Hospital | And 2 more authors.
Japanese Journal of Radiology | Year: 2010

Malignant transformation or tumor rupture is a rare complication of ovarian mature cystic teratomas. We present computed tomography (CT) images of a 52-year-old woman that revealed a large, predominantly cystic mass filled with fat and enhanced solid components located in the lower abdomen. Ten days later, the cystic mass ruptured, and massive ascites was observed on magnetic resonance imaging (MRI). Resulting from the rupture, MRI revealed reduced size and thickening wall of the tumor. After resection, the mass ruptured, and malignant transformation (squamous cell carcinoma) was observed. To our knowledge, there are no reports describing before and after images of a ruptured cystic teratoma with malignant transformation. © 2010 Japan Radiological Society.

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