Saiseikai Tondabayashi Hospital
Saiseikai Tondabayashi Hospital
Morikawa C.,Tezukayama Rehabilitation Hospital |
Kusumi R.,Osaka Police Hospital |
Ae M.,Saiseikai Tondabayashi Hospital |
Mori C.,Saiseikai Suita Hospital |
Iwata A.,Osaka Prefecture University
Rigakuryoho Kagaku | Year: 2017
[Purpose] This study aimed to determine the effect of an individual’s ability to select an appropriate joint position on physical performance. [Subjects and Methods] Forty-six young females participated in this study. Their ability to select an appropriate knee joint position was determined based on two different knee joint angles. The first was the angle at which the participants expected to show the miximum knee extensor strength, and the second was the angle at which their strength actually peaked. The subjects were divided into two groups according to their ability to select an appropriate knee joint position. We measured the subjects’ sprint and vertical jump performance, and examined performance differences between the two groups. [Results] The subjects that exhibited a greater ability to select an appropriate knee joint position demonstrated significantly better sprint and jump performance. [Conclusion] The ability to select an appropriate joint position has a large effect on physical performance. © 2017, Society of Physical Therapy Science (Rigaku Ryoho Kagakugakkai). All rights reserved.
PubMed | Red Cross, Saiseikai Tondabayashi Hospital, Akashi Medical Center, Hiroshima General Hospital of West Japan Railway Company and 6 more.
Type: Journal Article | Journal: Clinical endocrinology | Year: 2016
In adrenal vein sampling (AVS) for patients with primary aldosteronism, the contralateral ratio of aldosterone/cortisol (A/C) between the nondominant adrenal vein and the inferior vena cava is one of the best criteria for determining lateralized aldosterone secretion. Despite successful cannulation in some patients, the A/C ratios in the adrenal veins are bilaterally lower than that in the inferior vena cava (bilateral aldosterone suppression; BAS).To investigate the prevalence of BAS in AVS and how to resolve this condition.Retrospective study involving nine referral centres.Four hundred and ninety-one patients who were confirmed as having primary aldosteronism and had an AVS between January 2006 and December 2013.The prevalence of BAS before and after ACTH stimulation was compared. In addition, we investigated other methods for overcoming BAS.In 304 patients with successful AVS before ACTH stimulation, BAS was observed in 29 (95%). BAS was resolved after ACTH stimulation in 22 patients. In 276 patients with successful AVS both before and after ACTH stimulation, the frequency of BAS was significantly reduced after ACTH (87% vs 25%, P < 001). In a few patients, BAS was also resolved by adding a sampling point at the common trunk of the left adrenal vein and by an alternative drainage vein from the adrenal tumour.BAS sometimes occurs in AVS without ACTH stimulation. ACTH stimulation significantly reduces BAS with a single AVS procedure.
PubMed | Ageo Central General Hospital, Saiseikai Tondabayashi Hospital, Daiichi Sankyo, Waseda University and 6 more.
Type: | Journal: Cardiovascular intervention and therapeutics | Year: 2017
Prasugrel is a third-generation thienopyridine that achieves potent platelet inhibition with less pharmacological variability than other thienopyridines. However, clinical experience suggests that prasugrel may be associated with a higher risk of de novo and recurrent bleeding events compared with clopidogrel in Japanese patients undergoing percutaneous coronary intervention (PCI). In this review, we evaluate the risk of bleeding in Japanese patients treated with prasugrel at the doses (loading/maintenance doses: 20/3.75mg) adjusted for Japanese patients, evaluate the risk factors for bleeding in Japanese patients, and examine whether patients with a bleeding event are at increased risk of recurrent bleeding. This review covers published data and new analyses of the PRASFIT (PRASugrel compared with clopidogrel For Japanese patIenTs) trials of patients undergoing PCI for acute coronary syndrome or elective reasons. The bleeding risk with prasugrel was similar to that observed with the standard dose of clopidogrel (300/75mg), including when bleeding events were re-classified using the Bleeding Academic Research Consortium criteria. The pharmacodynamics of prasugrel was not associated with the risk of bleeding events. The main risk factors for bleeding events were female sex, low body weight, advanced age, and presence of diabetes mellitus. Use of a radial puncture site was associated with a lower risk of bleeding during PCI than a femoral puncture site. Finally, the frequency and severity of recurrent bleeding events during continued treatment were similar between prasugrel and clopidogrel. In summary, this review provides important insights into the risk and types of bleeding events in prasugrel-treated patients.Trial registration numbers: JapicCTI-101339 and JapicCTI-111550.
PubMed | Red Cross, National Hospital Organisation, Saiseikai Tondabayashi Hospital, Akashi Medical Center and 6 more.
Type: Journal Article | Journal: Clinical endocrinology | Year: 2016
Although adrenal vein sampling (AVS) is the standard method for subtype diagnosis in primary aldosteronism (PA), protocol details including the sampling position in the adrenal vein are not standardized.To establish the optimum sampling position in the left adrenal vein based on postoperative outcome in PA patients.Retrospective study in nine referral centres.Of 496 consecutive PA patients who underwent AVS between 2006 and 2013, 217 with successful AVS under cosyntropin stimulation, and with concomitant data from two positions: proximal (common trunk) and distal (central vein) to the junction with the inferior phrenic vein, were included.Discordant rate of subtype diagnosis between common trunk and central vein, and postoperative outcomes in patients with discordant results.Subtype diagnosis using common trunk and central vein was discordant in 10 (46%) of the 217 patients ( = 087, P < 005). Of these 10 patients, eight with left unilateral subtype and two with bilateral subtype using common trunk data showed bilateral subtype and unilateral subtype, respectively, using central vein data. Five patients with left unilateral subtype and one with bilateral subtype by common trunk data underwent unilateral adrenalectomy. All six patients were cured of PA after adrenalectomy, resulting in false-negative rates of 17% (1/6) by common trunk data, and 83% (5/6) by central vein data.In view of its better potential diagnostic accuracy, technical ease, lower cost and lower risk of vein rupture, blood sampling from the common trunk of the left adrenal vein may be preferable as the standard method of AVS in patients with PA, although additional studies in a larger number of cases are required.
Taguchi T.,Osaka University |
Nakayama T.,Sakai Municipal Hospital |
Masuda N.,Osaka National Hospital |
Yoshidome K.,Osaka Police Hospital |
And 6 more authors.
Chemotherapy | Year: 2010
Background: Capecitabine is an established therapy for metastatic breast cancer. In Japan, a 4 weekly regimen is often used, but data for this schedule in the first-line setting are lacking. Methods: Metastatic breast cancer patients who had received no chemotherapy for recurrent disease received capecitabine 825 mg/m2 twice daily, on days 1-21 of a 28-day cycle until disease progression or unacceptable toxicity. The primary endpoint was response rate. Results: In 33 eligible patients, median age was 53 years (range 27-73). Prior adjuvant therapy included an anthracycline in 90% and a taxane in 40%. The response rate was 18%; a further 24% had stable disease for ≥6 months. Median progression-free and overall survival were 6.9 and 24.8 months, respectively. The only grade 3 events were neutropenia (6%) and hand-foot syndrome (15%). Conclusions: These preliminary results confirm previous data showing that a lower capecitabine dose is an active and well-tolerated first-line therapy for metastatic breast cancer. Copyright © 2010 S. Karger AG, Basel.
PubMed | Red Cross, Saiseikai Tondabayashi Hospital, Akashi Medical Center, Saiseikai Yokohama City Toubu Hospital and 6 more.
Type: | Journal: Journal of human hypertension | Year: 2016
Although laterality assessed by computed tomography (CT) in primary aldosteronism (PA) is not always concordant with that assessed by adrenal vein sampling (AVS), it is unclear whether all patients diagnosed with PA should undergo AVS for subtype classification. The aim of the current study was to investigate the accuracy of CT in subtype classification and to develop a prediction score for bilateral subtype in patients without adrenal tumour. As part of the WAVES-J study, 393 patients with PA were analysed. Subtyping using CT was concordant with that using AVS in 68% (269/393) of patients in the total sample, and in 38% (68/156) of patients with unilateral tumours, 56% (5/9) of patients with bilateral tumours and 89% (204/228) of patients without tumour. In patients without tumour, female gender, plasma aldosterone concentration (pgml
PubMed | Red Cross, Saiseikai Tondabayashi Hospital, Akashi Medical Center, National Hospital Organization Kyoto Medical Center and 8 more.
Type: Journal Article | Journal: Clinical endocrinology | Year: 2015
Adrenal vein sampling (AVS) is the standard criterion for the subtype diagnosis in primary aldosteronism (PA). Although lateralized index (LI) 4 after cosyntropin stimulation is the commonly recommended cut-off for unilateral aldosterone hypersecretion, many of the referral centres in the world use LI cut-off of <4 without sufficient evidence for its diagnostic accuracy.The aim of the study was to establish the diagnostic significance of contralateral (CL) aldosterone suppression for the subtype diagnosis in patients with LI <4 in AVS.A retrospective multicentre study was conducted in Japan. Of 124 PA patients subjected to unilateral adrenalectomy after successful AVS with cosyntropin administration, 29 patients with LI<4 were included in the study. The patients were divided into Group A with CL suppression (n=16) and Group B (n=13) without CL suppression. Three outcome indices were assessed after 6months postoperatively: normalization/significant improvement of hypertension, normalization of the aldosterone to renin ratio (ARR) and normalization of hypokalaemia.The normalization/significant improvement of hypertension was 81% in Group A and 54% in Group B (P=02). The normalization of ARR was 100% in Group A and 46% in Group B (P=0004). Hypokalaemia was normalized in all patients of both groups. The overall cure rate of PA based on meeting all the three criteria was 81% in Group A and 31% in Group B (P=001).In patients with PA, where the LI is <4 on AVS, CL suppression of aldosterone is an accurate predictor of a unilateral source of aldosterone excess. CL suppression data should be interpreted in conjunction with computed tomographic adrenal imaging findings to guide surgical management.
PubMed | Saiseikai Tondabayashi Hospital and Osaka City University
Type: Journal Article | Journal: Medical molecular morphology | Year: 2016
Elastofibroma is a rare tumour that occurs in the subscapular space, and it typically presents in middle-aged and older individuals. The aetiology of elastofibroma remains unknown. Recent, sporadic reports have shown, immunohistologically, that fibroblasts in elastofibroma may produce abnormal elastic and collagen fibres through the action of transforming growth factor-beta (TGF-), a factor that promotes fibroblast proliferation. However, that finding lacked quantitative measurements and controls. Therefore, in this study, we performed quantitative, immunohistochemical analyses of TGF-1 and basic fibroblast growth factor (bFGF) in three elastofibromas, and we compared them to ten dermatofibromas and keloids, and five normal skin. In elastofibroma specimens, 16-59% fibroblasts were positive for TGF-1 in the cytoplasm, compared to 96% in dermatofibroma, 93% in keloid and 2% in normal dermis specimens. Also, in elastofibroma specimens, 26-67% of fibroblasts were positive for bFGF in the cytoplasm, compared to 97% in dermatofibroma, 97% in keloid, and 22% in normal dermis specimens. Intriguingly, the tumour size and growth rate were proportional to the percentage of cells positive for bFGF. Finally, greater levels of bFGF expressions in fibroblasts were associated with larger sized elastofibromas. These results suggested that elastofibroma development depended on high expression of TGF-1 and bFGF.
Hayashibe A.,Saiseikai Tondabayashi Hospital
International Journal of Surgery | Year: 2013
Background: Mechanical stapling method is widely established alternative to conventional hand suturing. Method: For gastrointestinal anastomoses. In this study, we compare the clinical results of mechanical stapling with those of hand suturing for gastrojejunostomy and jejunojejunostomy after Subtotal Stomach Preserving Pancreaticojejunostomy (SSPPD). Methods: Between 2002 and 2007, 42 patients who underwent SSPPD with concise records on operative procedure and time required for gastrojejunostomy and jejunojejunostomy were enrolled. Out of 42 patients, the mechanical stapling for gastrojejunostomy and jejunojejunostomy after SSPPD was performed for 19 patients and hand suturing for those in SSPPD was done for 23 patients. Results: All clinical characteristics were similar in both groups. There was no statistical difference between both groups in the rate of complications related to gastrojejunostomy and jejunojejunostomy. However, days of nasogastric intubation and days until liquid diet in the stapled group were significantly shorter than those in the hand sutured group. Time required for gastrojejunostomy and jejunojejunostomy was significantly shorter in the stapled group than in the hand sutured group. Conclusions: This study suggested that stapled anastomoses might require a shorter time to perform and decreased time for nasogastric intubation and until liquid diet is introduced. © 2012 Surgical Associates Ltd.
Nakabou M.,Saiseikai Tondabayashi Hospital |
Kai T.,Saiseikai Tondabayashi Hospital |
Maeshima T.,Saiseikai Tondabayashi Hospital |
Kanamasa K.,Saiseikai Tondabayashi Hospital
Clinical and Experimental Nephrology | Year: 2010
We herein report two cases of patients with chronic kidney disease who developed hypertensive encephalopathy, which occurred after a sudden discontinuance of antihypertensive agents. Both patients underwent care at our hospital after experiencing neurological abnormalities. In both patients, magnetic resonance imaging (MRI) revealed edema in the cerebral white matter and cortices, basal ganglia, brainstem, and cerebellum. Though recently the number of reports about hypertensive encephalopathy has decreased, we describe two case reports and also review the pertinent literature. © Japanese Society of Nephrology 2009.