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Osaki A.,Niigata University | Suda T.,Niigata University | Waguri N.,Niigata City General Hospital | Ishikawa T.,Saiseikai Niigata Second Hospital | And 8 more authors.
Journal of Vascular and Interventional Radiology

Purpose: To establish a formula to guide appropriate embolization volume for postprocedural platelet gain following partial splenic arterial embolization (PSE) for hypersplenism. Materials and Methods: The hepatic volume (Vh) and splenic volume (Vsp) were measured by using 2-mm-thick computed tomography images before and after PSE in 20 patients with various chronic liver diseases. A formula was derived from the relationship between the platelet count increase ratio (dPlt%) and the organ volumes, which was then evaluated in another cohort. Results: After an embolization of a median of 72.1% of the spleen (interquartile range, 38.2%-93.8%), the dPlt% was 67.7% ± 40.0 and significantly correlated with the increasing ratio of Vh to Vsp (P = .019, ρ = 0.52). Because the difference in Vh/Vsp ratio after PSE was significantly correlated with the spleen embolization ratio (eVsp%; P = .0003, ρ = 0.72), the estimated dPlt% could be derived from the Vh/Vsp ratio before PSE and the eVsp%. The estimated dPlt% was significantly correlated with the actual dPlt% (P = .0003, ρ = 0.72). When the formula was evaluated in another cohort of 14 cases, another strict correlation was observed (P < .0001, ρ = 0.92). Conclusions: These data suggest that platelet count after PSE can be predicted before the procedure by using the Vh/Vsp ratio and the anticipated spleen embolization volume. The use of such a prediction can prevent too much or too little embolization, thereby leading to an improvement in the risk/return trade-off in PSE. © 2012 SIR. Source

Ishikawa T.,Saiseikai Niigata Second Hospital
World Journal of Gastroenterology

Hepatocellular carcinoma (HCC) is a major cause of cancer death, and chronic hepatitis B is a serious worldwide problem. The epidemiology of HCC is distinctive. Hepatitis B virus (HBV) plays a major role in hepatocarcinogenesis. Prevention of HBV-related HCC is a key issue in current hepatology. This paper describes the prevention and clinical features of HBV-related HCC, along with a short review of the disease. © 2010 Baishideng. Source

Shibasaki Y.,Niigata University | Seki Y.,Niigata Prefectural Shibata Hospital | Tanaka T.,Niigata University | Miyakoshi S.,Niigata University | And 16 more authors.
Leukemia Research

We focused on the level of reduction of Wilms' tumor gene 1 (WT1) mRNA in bone marrow as minimal residual disease during chemotherapies in adult acute myeloid leukemia (AML) patients. Forty-eight patients were enrolled in this study. Log levels of reduction of WT1 mRNA transcript after induction therapy compared with those at diagnosis were associated with disease-free survival (DFS) (. P=. 0.0066) and overall survival (OS) (. P=. 0.0074) in patients who achieved complete remission. Also log levels of reduction of WT1 mRNA transcript after final consolidation therapy compared with those at diagnosis were associated with DFS (. P=. 0.015) and OS (. P=. 0.012). By multivariate analysis, log levels of reduction of WT1 mRNA transcript after induction therapy and after final consolidation therapy compared with those at diagnosis were extracted as risk factors for outcome. Our results suggest that early and deep reduction of tumor burden may be important for the outcome of AML patients. In addition, it may be useful for the decision to proceed with allogeneic SCT as post-remission therapy. © 2015 Elsevier Ltd. Source

Seki K.,Saiseikai Niigata Second Hospital | Honma T.,Saiseikai Niigata Second Hospital | Nagashima A.,Niigata University | Togashi T.,Niigata Medical Center | And 5 more authors.
Endoscopic Forum for Digestive Disease

We report two cases of early gastric cancer arising in one of multiple gastric hyperplastic polyps after eradication of Helicobacter pylori (H. pylori). Case 1 had been followed for 5 years after eradication. A polyp decreased in size and a tiny depressed area appeared at the top of the polyp. The biopsy specimen from the lesion revealed moderately to poorly differentiated adenocarcinoma and the lesion was completely resected by endoscopic submucosal dissection (ESD). Case 2 showed a change in shape from a pedunculated polyp to a depressed lesion in 6 months after eradication of H. pylori. The biopsy specimen revealed moderately differentiated adenocarcinoma and the lesion was resected by ESD. These cases suggest that a cancer arising from the diminishing hyperplastic polyps may exist among the patients eradicated of H. pylori. Careful survey is in order. Source

Sogawa M.,Niigata Prefectural Central Hospital | Fukuda T.,Saiseikai Niigata Second Hospital | Tayama M.,Saiseikai Niigata Second Hospital | Moro H.,Saiseikai Niigata Second Hospital | Ishihara N.,Saiseikai Niigata Second Hospital
General Thoracic and Cardiovascular Surgery

An asymptomatic 73-year-old man underwent resection of a cardiac tumor arising fromthe right ventricular outflow tract, and reconstruction of the right ventricular outflow tract using an expanded polytetrafluoroethylene sheet. Histological examination revealed a cavernous-capillary type cardiac hemangioma, which is a very rare cardiac tumor. © The Japanese Association for Thoracic Surgery 2012. Source

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