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Umeoka F.,Saiseikai Matusuyama Hospital | Miyaoka H.,Saiseikai Matusuyama Hospital | Oka Y.,Saiseikai Matusuyama Hospital | Inada N.,Saiseikai Matusuyama Hospital | Okada T.,Saiseikai Matusuyama Hospital
Journal of the Japan Diabetes Society

The frequency of hepatocellular carcinoma (HCC) with underlying nonalcoholic steatohepatitis (NASH) is increasing, and insulin resistance due to underlying obesity and diabetes is suspected of playing a role in hepatic carcinogenesis. This study divided 80 patients with type 2 diabetes and coexisting chronic liver disease into patients with HCC (n = 36) and without HCC (n = 44), then compared insulin resistance and frequency of use of insulin and oral hypoglycemic agents (insulin secretion-stimulating drugs, and metformin). Fasting serum insulin was 14.5 ± 5.5 μ U/m/ in the HCC group and 8.65 ± 5.0 μ U/ml in the non-HCC group. The homeostasis model assessment-insulin resistance index was 4.34 ± 1.74 in the HCC group and 2.53 ± 1.21 in the nonHCC group. In both cases, values were significantly higher in the HCC group (P < 0.05). In addition, the frequency of metformin use was significantly lower in the HCC group than in the non-HCC group. This suggests that treatment of insulin resistance with metformin may reduce the incidence of HCC. Source

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