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Amagasaki, Japan

Araki T.,Saiseikai Kanazawa Hospital | Tsuchiya T.,Kanazawa Cardiovascular Hospital
Journal of the Japan Diabetes Society | Year: 2010

Eicosapentaenoic acid (EPA) treatment is recommended by the Japan Atherosclerosis Society for high-risk hypercholesterolemic subjects, including those with diabetes mellitus. A high ratio of plasma EPA to arachidonic acid (AA) is reported to reduce coronary event incidence. Serum malondialdehyde- modified lowdensity lipoprotein (MDA-LDL), a major component of oxidized LDL, is a useful marker for predicting coronary events in those with diabetes. We studied the relationship between the EPA/A A ratio and serum MDA-LDL concentration in 60 subjects with type 2 diabetes mellitus divided into group A (n = 30, EPA/A A ratio <0.5) and group B (n = 30; EPA/A A ratio >0.5). Serum MDA-LDL was significantly higher in group A than in group B (86 ± 22 U/L vs 73 ± 20 U/L). Serum MDA-LDL decreased significantly from 92 ± 27 U/L at baseline to 70 ± 23 U/L in 12 group A subjects administered 1,800 mg of EPA daily for 3 months after EPA treatment, with the EPA/AA ratio increasing from 0.35 ± 0.08 to 1.20 ± 0.53. These results suggest that EPA treatment may reduce the oxidative stress observed in those with diabetes and a low EPA/AA ratio. Source


Sasaki T.,Kanazawa University | Ota T.,Tonami General Hospital | Ookura Y.,Saiseikai Kanazawa Hospital | Sugiyama K.,Kanazawa University
Clinical Ophthalmology | Year: 2012

Background: The purpose of this work was to report on the performance of medial blepharosynechioplasty (MBSP), a newly devised technique for treating severe dry eye. Methods: In this retrospective, nonrandomized clinical trial, three cases with severe dry eye (Sjögren's syndrome) associated with repeated punctal plug loss were treated using MBSP to create a synechia between the upper and lower lid medial borders of the puncta to suppress the lacrimal pump. Results: Postoperative follow-up showed improvement in the corneal condition in all three cases that persisted for 12-35 months. None of the patients had visual impairment. Conclusion: MBSP is a promising treatment for severe dry eye and merits further study. © 2012 Sasaki et al, publisher and licensee Dove Medical Press Ltd. Source


Katano K.,Saiseikai Kanazawa Hospital | Kakuchi Y.,Saiseikai Kanazawa Hospital | Nakashima A.,Saiseikai Kanazawa Hospital | Takahashi S.,Saiseikai Kanazawa Hospital | Kawano M.,Kanazawa University
Clinical Nephrology | Year: 2011

Hepatic and/or renal cyst infection is a major complication in patients with polycystic kidney disease. In many cases, drainage of infected cysts is necessary, although accurate detection of infected cysts from among the numerous hepatic or renal cysts present is often difficult, because the findings of infected cysts on computed tomography and T1- and T2-weighted magnetic resonance imaging resemble those of normal cysts. We describe here a case of polycystic kidney disease complicated by hepatic cyst infection. On diffusion-weighted magnetic resonance imaging (DWMRI), which is occasionally used in the diagnosis of cerebral abscesses, infected hepatic cysts showed higher signal intensity than other cysts, facilitating differentiation of the cysts requiring drainage from numerous other cysts. Infected cysts showed a marked decrease of the apparent diffusion coefficient (ADC) values compared with those of normal cysts. DWMRI was very effective in detecting infected cysts in our patient and may be of value in other such cases with polycystic kidney disease. ©2011 Dustri-Verlag Dr. K. Feistle. Source


Katano K.,Saiseikai Kanazawa Hospital | Kakuchi Y.,Saiseikai Kanazawa Hospital | Nakashima A.,Saiseikai Kanazawa Hospital | Nakahama K.,Saiseikai Kanazawa Hospital | Kawano M.,Kanazawa University
Clinical and Experimental Nephrology | Year: 2010

A 54-year-old Japanese man entered our hospital for investigation of appetite loss. His blood pressure was 201/113 mmHg, and laboratory findings revealed renal failure and hyponatremia. On physical examination, disorientation and dysarthria were observed. Hemodialysis was performed the same day. Magnetic resonance imaging (MRI) after hemodialysis revealed swelling of the brainstem and a high signal intensity on fluid-attenuated inversion recovery (FLAIR) imaging, similar to findings of central pontine myelinolysis (CPM), which is generally irreversible. However, on an apparent diffusion coefficient (ADC) map based on diffusion-weighted MRI, higher signal intensity was observed in the area of the high signal intensity on FLAIR imaging, which is not seen in CPM. The abnormal neurological symptoms improved within a few days, and MRI findings also normalized. We diagnosed the lesion as the brainstem variant of reversible posterior leukoencephalopathy syndrome (RPLS) with uremia. ADC map was very useful in diagnosing RPLS with uremia. © 2010 Japanese Society of Nephrology. Source


Mori K.,Houju Memorial Hospital | Yamada K.,Kanazawa University | Konno T.,Kanazawa University | Inoue D.,Kanazawa University | And 6 more authors.
Internal Medicine | Year: 2015

We herein report the case of a 65-year-old man with pericardial involvement associated with autoimmune pancreatitis. Chest CT imaging showed pericardial thickening. The patient responded to corticosteroid therapy, and the pericardial thickening resolved. Multiple organs are involved in immunoglobulin G4 (IgG4)- related disease (IgG4-RD); however, only a few cases of IgG4-related chronic constrictive pericarditis have been reported. To our knowledge, this is the first reported case of IgG4-RD with pericardial involvement at an early stage. This case indicates that recognizing pericardial complications in autoimmune pancreatitis is important and that CT imaging may be useful for obtaining the diagnosis and providing follow-up of pericardial lesions in cases of IgG4-RD. © 2015 The Japanese Society of Internal Medicine. Source

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