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Mendzheritskii A.M.,Pedagogical Institute of the South Federal University | Karantysh G.V.,Pedagogical Institute of the South Federal University | Abramchuk V.A.,Pedagogical Institute of the South Federal University | Ryzhak G.A.,Saint Petersburg Institute of Bioregulation and Gerontology
Advances in Gerontology | Year: 2014

The effects of peptide geroprotectors, such as cortexin and pinealon, on the training of rats of different ages and the caspase-3 system in their brain structures were studied in the experimental model of acute hypoxic hypoxy. Regional changes were identified in the activity and the content of caspase-3 in the cerebral cortex and brainstem structures of young and old rats under the influence of peptide preparations. It is suggested that the functional state of the caspase-3 system in the brain is one of the reasons for the ability of animals to learn. Compared with cortexin, pinealon has a greater positive effect on the learning of both young and old animals in the Morris labyrinth. © 2014 Pleiades Publishing, Ltd. Source


Sidorenko A.V.,European Center for Social Welfare Policy and Research | Mikhailova O.N.,Saint Petersburg Institute of Bioregulation and Gerontology
Advances in Gerontology | Year: 2014

In this article, government policies on ageing in the CIS countries and Georgia (CIS+) are discussed. The implementation process of the Madrid International Plan of Action on Aging (MIPAA) from 2002 to 2012 was chosen as a framework for analyzing the government policy on ageing. The article begins with a concise overview of the demographic situation in the CIS+ countries, which belong to various stages of demographic transition. In conclusion, policy goals for implementing MIPAA during its third implementation cycle (2013-2017) are presented. © 2014 Pleiades Publishing, Ltd. Source


Khavinson V.Kh.,RAS Pavlov Institute of Physiology | Lin'kova N.S.,Saint Petersburg Institute of Bioregulation and Gerontology | Polyakova V.O.,Russian Academy of Medical Sciences | Durnova A.O.,Russian Academy of Medical Sciences | And 2 more authors.
Bulletin of Experimental Biology and Medicine | Year: 2014

We studied the effect of polypeptide complex isolated from calf kidney and short peptides T-31 (AED) and T-35 (EDL) on the expression of signaling molecules, markers of cell renewal (Ki-67, p53), remodeling of the extracellular matrix (MMP-14), and immune response (IL-8) in primary kidney cell cultures during aging. The complex of renal polypeptides and T-31 peptide activate cell renewal processes during aging of the renal epithelium, while gelatinase MMP-14 is the target of T-35 peptide. © 2014 Springer Science+Business Media. Source


Khavinson V.Kh.,RAS Pavlov Institute of Physiology | Linkova N.S.,Saint Petersburg Institute of Bioregulation and Gerontology | Kvetnoy I.M.,Saint Petersburg Institute of Bioregulation and Gerontology | Kvetnaia T.V.,Saint Petersburg Institute of Bioregulation and Gerontology | Polyakova V.O.,Saint Petersburg Institute of Bioregulation and Gerontology
Bulletin of Experimental Biology and Medicine | Year: 2012

The effects of epithalone and vilone peptides on the synthesis of melatonin and factors involved in this process, arylalkylamine-N-acetyltransferase (AANAT) enzyme and pCREB transcription protein, were studied in rat pinealocyte culture. Epithalone stimulated AANAT and pCREB synthesis and increased melatonin level in culture medium. Simultaneous addition of norepinephrine and peptides into the culture potentiated the expression of AANAT and pCREB. © 2012 Springer Science+Business Media, Inc. Source


Khavinson V.,Saint Petersburg Institute of Bioregulation and Gerontology | Ribakova Y.,Russian Academy of Medical Sciences | Kulebiakin K.,Moscow State University | Vladychenskaya E.,Moscow State University | And 3 more authors.
Rejuvenation Research | Year: 2011

The synthetic tripeptide pinealon (Glu-Asp-Arg) demonstrates dose-dependent restriction of reactive oxygen species (ROS) accumulation in cerebellar granule cells, neutrophils, and pheochromocytoma (PC12) cells, induced by oxidative stress stimulated by receptor-dependent or-independent processes. At the same time, pinealon decreases necrotic cell death measured by the propidium iodide test. The protective effect of pinealon is accompanied with a delayed time course of ERK 1/2 activation and modification of the cell cycle. Because restriction of ROS accumulation and cell mortality is saturated at lower concentrations, whereas cell cycle modulation continues at higher concentrations of pinealon, one can conclude that besides its known antioxidant activity, pinealon is able to interact directly with the cell genome. © 2011 Mary Ann Liebert, Inc. Source

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