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Winona, MN, United States

Saint Mary's University of Minnesota, founded in 1912, is a private, comprehensive, coeducational university with an undergraduate campus in the city of Winona, Minnesota, United States. Graduate and professional programs are offered at facilities in Winona, the Twin Cities, Rochester, Apple Valley, Minnetonka and Oakdale, Minnesota; and various course delivery sites around Minnesota and Wisconsin; Jamaica, and Nairobi, Kenya Wikipedia.

Poret N.,Institut Universitaire de France | Fu Q.,Foundation Medicine | Guihard S.,Institut Universitaire de France | Cheok M.,Institut Universitaire de France | And 7 more authors.
Cancer Research | Year: 2015

Hairy cell leukemia (HCL) is characterized by underexpression of the intracellular signaling molecule RhoH. Reconstitution of RhoH expression limits HCL pathogenesis in a mouse model, indicating this could represent a new therapeutic strategy. However, while RhoH reconstitution is theoretically possible as a therapy, it is technically immensely challenging as an appropriately functional RhoH protein needs to be specifically targeted. Because of this problem, we sought to identify drug-gable proteins on the HCL surface that were dependent upon RhoH underexpression. One such protein was identified as CD38. Analysis of 51 HCL patients demonstrated that 18 were CD38-positive. Interrogation of the clinical record of 23 relapsed HCL patients demonstrated those that were CD38-positive had a mean time to salvage therapy 71 months shorter than patients who were CD38-negative. Knockout of the CD38 gene in HCL cells increased apoptosis, inhibited adherence to endothelial monolayers, and compromised ability to produce tumors in vivo. Furthermore, an anti-CD38 antibody proved effective against pre-existing HCL tumors. Taken together, our data indicate that CD38 expression in HCL drives poor prognosis by promoting survival and heterotypic adhesion. Our data also indicate that CD38-positive HCL patients might benefit from treatments based on CD38 targeting. © 2015 American Association for Cancer Research. Source

Kowles R.V.,Saint Marys University of Minnesota
Bioscene | Year: 2010

Cell water relationships are important topics to be included in cell biology courses. Differences exist in the control of water relationships in plant cells relative to control in animal cells. One important reason for these differences is that turgor pressure is a consideration in plant cells. Diffusion and osmosis are the underlying factors involved in the control of water in plant cells; however, additional attention must be given to osmotic pressure, osmotic potential, and water potential. This discussion shows how these parameters relate to each other, and how they are explained by thermodynamics and the universal gas laws. Detailed laboratory exercises are described that demonstrate these principles. The laboratory exercises include data collection, graphing of data, statistical analysis of data, and calculations of osmotic potential and diffusion pressure deficit from the data. Source

Berg-Binder M.C.,University of Illinois at Urbana - Champaign | Berg-Binder M.C.,Saint Marys University of Minnesota | Suarez A.V.,University of Illinois at Urbana - Champaign
Oecologia | Year: 2012

Ant-mediated seed dispersal may be a form of directed dispersal if collected seeds are placed in a favorable microhabitat (e. g., in or near an ant nest) that increases plant establishment, growth, and/or reproduction relative to random locations. We investigated whether the native ant community interacts with invasive leafy spurge (Euphorbia esula) in a manner consistent with predictions of the directed dispersal hypothesis. Resident ants quickly located and dispersed 60% of experimentally offered E. esula seeds. Additionally, 40% of seeds whose final deposition site was observed were either brought inside or placed on top of an ant nest. Seed removal was 100% when seeds were placed experimentally on foraging trails of moundbuilding Formica obscuripes, although the deposition site of these seeds is unknown. Natural density and aboveground biomass of E. esula were greater on Formica mound edges compared to random locations. However, seedling recruitment and establishment from experimentally planted E. esula seeds was not greater on mound edges than random locations 3 m from the mound. Soil from Formica mound edges was greater in available nitrogen and available phosphorus relative to random soil locations 3 m from the mound. These results suggest Formica ant mounds are favorable microhabitats for E. esula growth following seedling establishment, a likely consequence of nutrient limitation during plant growth. The results also indicate positive species interactions may play an important role in biological invasions. © 2012 Springer-Verlag. Source

Gillick B.T.,University of Minnesota | Zirpel L.,Saint Marys University of Minnesota
Archives of Physical Medicine and Rehabilitation | Year: 2012

Gillick BT, Zirpel L. Neuroplasticity: an appreciation from synapse to system. Objective: To integrate our functional knowledge in neurorehabilitation with a greater understanding of commonly held theories and current research in neuroplasticity. Design: Literature review. Setting: Not applicable. Participants: Animal and human research. Interventions: Interventions specific to application in humans: constraint-induced movement therapy, transcranial magnetic stimulation, and transcranial direct current stimulation. Main Outcome Measures: Cortical excitability, blood oxygen level-dependent signal, and functional outcomes. Results: There is increasing evidence elucidating the cellular and molecular mechanisms of plasticity of the nervous system including growth, modification, degradation, and even death of neurons. Some of these mechanisms directly correlate with therapy-induced behavioral changes, and all provide an understanding of the response of the nervous system to altered inputs. The understanding of neural correlates of behavior can then form the foundation for more productive, comprehensive interventions. Conclusions: The focus of recent research surrounds translational projects aimed at enhancing clinical outcomes. Knowledge of mechanisms underlying this adaptability is the foundation for our treatments, diagnoses, and prognoses. The increasing understanding of the mechanisms underlying neuroplasticity can guide, direct, and focus the practice of current and future therapies to greater efficacy and better functional outcomes in clinical rehabilitation. © 2012 American Congress of Rehabilitation Medicine. Source

Emmett B.,Saint Marys University of Minnesota | Cochran P.A.,University of Washington
Journal of Freshwater Ecology | Year: 2010

The tadpole madtom (Noturus gyrinus) is highly prized as bait in the upper Mississippi River valley, where it is marketed as the "willow cat," yet it has venom glands associated with spines in its pectoral and dorsal fins. The response of a predatory fish to this defense was tested by exposing tadpole madtoms to largemouth bass (Micropterus salmoides). Results were compared to the response by bass to fathead minnows (Pimephales promelas). Each of four bass was used in six trials with madtoms and six trials with minnows. Trials with madtoms and minnows were alternated, and all trials were videotaped. Largemouth bass were just as likely to consume tadpole madtoms as minnows. Bass sometimes took longer to handle and consume tadpole madtoms than minnows, but the likelihood of attack did not change as the number of trials increased. Behaviors that may be associated with discomfort, such as gill flaring and coughing, occurred significantly more often after consumption of madtoms, but bass always seemed ready to consume additional prey, and no bass displayed any negative long term effects. Source

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