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St. Louis, MO, United States

Saint Louis University is a private research university with campuses in St. Louis, Missouri and Madrid, Spain. Founded in 1818 by the Most Reverend Louis Guillaume Valentin Dubourg, SLU is the oldest university west of the Mississippi River and the second-oldest Jesuit university in the nation. It is one of 28 member institutions of the Association of Jesuit Colleges and Universities. The university is accredited by the North Central Association of Colleges and Secondary Schools. SLU's athletic teams compete in NCAA's Division I and the Atlantic 10 Conference. It has a current enrollment of 13,505 students, including 8,687 undergraduate students and 4,818 graduate students, representing all 50 states and more than 70 foreign countries. Its average class size is 23.8 and the student-faculty ratio is 12:1.For over 30 years the university has maintained a campus in Madrid, Spain. The Madrid campus was the first freestanding campus operated by an American university in Europe and the first American institution to be recognized by Spain's higher education authority as an official foreign university. The campus has 675 students, a faculty of 110, an average class size of 15 and a student-faculty ratio of 7:1.Fred Pestello is the current President, serving as the 33rd President of SLU since July 1, 2014. He is the first layman to be president in the school's history Wikipedia.

Shah R.,Saint Louis University
Journal of the American Medical Directors Association | Year: 2013

The role of nutrition in modulating Alzheimer disease (AD) remains uncertain. Persons ingesting a Mediterranean-type diet appear to be less likely to develop AD. Epidemiologically, food combinations rich in antioxidant vitamins reduced the risk of AD. Combination formulas (eg, Souvenaid) appear to have small effects on cognition. B-vitamin supplements were mostly disappointing with inconsistent findings, except in countries where bread is not fortified with folate. They were generally negative, as were studies investigating omega-3 fatty acid supplementation. Based on this review, a Mediterranean diet and/or a combination supplement, such as Souvenaid, appear to be the most beneficial approaches with the least possible adverse effects to slowing the progression of AD. © 2013 American Medical Directors Association, Inc.

Puetz J.,Saint Louis University
Journal of Thrombosis and Haemostasis | Year: 2013

Although fresh frozen plasma (FFP) is one of the most commonly prescribed therapies in clinical practice throughout the world today, there is little medical evidence available supporting its use. Recent guidelines have called for limiting FFP transfusions. Despite this, FFP use does not seem to be decreasing. The reasons for this are likely to be multifactorial, and may be based on ideas regarding medical practices dating back to Galen and Hippocrates. A review of the history of the development of FFP may shed some light on current clinical practice and guide the direction of future investigations and therapies. © 2013 International Society on Thrombosis and Haemostasis.

Dorsett D.,Saint Louis University | Merkenschlager M.,Imperial College London
Current Opinion in Cell Biology | Year: 2013

Cohesin is an evolutionarily ancient multisubunit protein complex with a deeply conserved function: it provides cohesion between sister chromatids from the time of DNA replication in S-phase until mitosis. This cohesion facilitates repair of damage that occurs during DNA replication, and, crucially, enforces faithful segregation of chromosomes upon cell division. Cohesin also influences gene expression, and relative to sister chromatid cohesion, gene expression is exquisitely sensitive to moderate changes in cohesin activity. Early studies revealed differences in cohesin's roles in gene expression between various organisms. In all organisms examined, however, cohesin marks a subset of active genes. This review focuses on the roles of cohesin at active genes, and to what extent these roles are conserved between organisms. © 2013 Elsevier Ltd.

Morley J.E.,Saint Louis University
Nature Reviews Neurology | Year: 2014

Epidemiological evidence strongly suggests that circulatory levels of 25-hydroxyvitamin D below 50 nmol/l are associated with cognitive impairment and the development of dementia. A number of biochemical mechanisms could explain these effects; however, interventional studies to date have revealed disappointingly little. © 2014 Macmillan Publishers Limited. All rights reserved.

Neuschwander-Tetri B.A.,Saint Louis University
Current Opinion in Clinical Nutrition and Metabolic Care | Year: 2013

Purpose of Review: Carbohydrate consumption has been implicated in the metabolic syndrome and nonalcoholic fatty liver disease (NAFLD). Reviewed here is basis for this relationship and the recent additional evidence that excessive dietary carbohydrate consumption, especially excessive fructose or sucrose consumption, is playing a role in the epidemic of NAFLD. RECENT FINDINGS: A recent cross-sectional epidemiological study has linked fructose consumption to the severity of fibrosis in patients with NAFLD. Clinical trials have shown that consumption of fructose-containing beverages, either has fructose or sucrose, contribute to the development of NAFLD compared to isocaloric alternatives, and that genetic polymorphisms that increase the entry of glucose into lipogenic pathways are associated with fatty liver disease. New animal studies provide additional evidence on the role of carbohydrate-induced de-novo lipogenesis and the gut microbiome in fructose-induced NAFLD. Data also suggest that fructose-induced uric acid production in the liver also plays a role in NAFLD independent of the role of fructose as a substrate for lipogenesis. SUMMARY: Epidemiological studies, clinical trials, and animal studies continue to point to excess dietary carbohydrate, and especially fructose, in contributing to the risk factors for NAFLD. © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins.

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