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Zito C.R.,Yale University | Zito C.R.,Saint Josephs College | Kluger H.M.,Yale University
Journal of Cellular Biochemistry | Year: 2012

Melanoma has traditionally been considered an immunogenic tumor. A number of approaches have been studied for enhancement of antitumor immunity. The first cytokine approved for the treatment of metastatic melanoma, interleukin-2, has resulted in prolonged responses in a small subset of patients, providing hope that immunotherapy might be useful for this disease. Ipilimumab, a monoclonal antibody to CTLA-4, was recently approved and a number of other promising investigational approaches are currently being pursued. This manuscript discusses more recent advances in the treatment of melanoma employing a variety of immune-enhancing approaches. © 2011 Wiley Periodicals, Inc.

Aselton P.,Saint Josephs College
Journal of Child and Adolescent Psychiatric Nursing | Year: 2012

PURPOSE: The study aims to explore the sources of stress in American college students who had been treated for depression and to discern their coping mechanisms. ORGANIZING FRAMEWORK: A phenomenological approach using Seidman's guide to in-depth qualitative interviews using a three-part approach was used in the study. METHOD: Online in-depth interviews utilizing e-mail with asynchronous communication were used. FINDINGS: Sources of stress included roommate issues, academic problems, financial and career concerns, and pressure from family. Exercise, talking to friends, self-talk, deep breathing, journaling, marijuana use, and listening to music were common coping mechanisms. CONCLUSIONS: College students who have been treated for depression are under increasing stress today from a variety of sources. Nonmedical methods of coping were often cited as more effective than medication therapy. © 2012 Wiley Periodicals, Inc.

Weiszbrod T.,Saint Josephs College
Health Care Manager | Year: 2015

As health care leader competencies continue to be refined and emphasized in health care administration educational programs, the "soft skills" of emotional intelligence have often been implied, but not included explicitly. The purpose of this study was to better understand what relationship, if any, could be identified between health care leader competencies and emotional intelligence. A quantitative correlational method of study was used, utilizing self-assessments and 360-degree assessments of both constructs. There were 43 valid participants in the study, representing the various types of health care delivery systems. Correlational analysis suggested there was a positive relationship; for each unit of increase in emotional intelligence, there was a 0.6 increase in overall health care leadership competence. This study did not suggest causation, but instead suggested that including the study and development of emotional intelligence in health care administration programs could have a positive impact on the degree of leader competence in graduates. Some curricula suggestions were provided, and further study was recommended.

Perez A.E.,West Virginia University | Haskell N.H.,Saint Josephs College | Wells J.D.,Florida International University
Forensic Science International | Year: 2014

Carrion insect succession patterns have long been used to estimate the postmortem interval (PMI) during a death investigation. However, no published carrion succession study included sufficient replication to calculate a confidence interval about a PMI estimate based on occurrence data. We exposed 53 pig carcasses (16 ± 2.5 kg), near the likely minimum needed for such statistical analysis, at a site in north-central Indiana, USA, over three consecutive summer seasons. Insects and Collembola were sampled daily from each carcass for a total of 14 days, by this time each was skeletonized. The criteria for judging a life stage of a given species to be potentially useful for succession-based PMI estimation were (1) nonreoccurrence (observed during a single period of presence on a corpse), and (2) found in a sufficiently large proportion of carcasses to support a PMI confidence interval. For this data set that proportion threshold is 45/53.Of the 266 species collected and identified, none was nonreoccuring in that each showed at least a gap of one day on a single carcass. If the definition of nonreoccurrence is relaxed to include such a single one-day gap the larval forms of Necrophila americana, Fannia scalaris, Cochliomyia macellaria, Phormia regina, and Lucilia illustris satisfied these two criteria. Adults of Creophilus maxillosus, Necrobia ruficollis, and Necrodes surinamensis were common and showed only a few, single-day gaps in occurrence.C. maxillosus, P. regina, and L. illustris displayed exceptional forensic utility in that they were observed on every carcass. Although these observations were made at a single site during one season of the year, the species we found to be useful have large geographic ranges. We suggest that future carrion insect succession research focus only on a limited set of species with high potential forensic utility so as to reduce sample effort per carcass and thereby enable increased experimental replication. © 2014 Elsevier Ireland Ltd.

Brodman R.,Saint Josephs College
Herpetological Conservation and Biology | Year: 2010

I have analyzed presence, abundance, and patterns of coexistence of 11 species of pond-breeding salamanders from 203 managed sites in Indiana, Illinois, Kentucky, Michigan, and Ohio. Among these include 47 longterm sites that have been monitored for 7-15 years. The two most abundant species, Ambystoma tigrinum and A. texanum, use open habitats such as grasslands and savanna, and are found in single species communities significantly more often than expected by a null model. Several other species were more likely to coexist with certain species in assemblages, and communities of four or more species occurred significantly more often than predicted by null models. All of the sites with four or more species have fishless seasonal or semi-permanent wetlands and forested upland habitat. Among populations with long-term data, five species declined at some sites and two species increased at some sites, however, most population dynamics were apparently stable fluctuations. The declining species were primarily found in mature forest upland habitat and typically breed in fishless seasonal wetlands, whereas the increasing species use open upland habitats and semi-permanent to permanent wetlands. Regression and General Linear Models indicate that the timing of prescribed burns was a significant factor in determining the relative abundance of pond-breeding salamanderlarvae. Prescribed burns during spring had a negative affect on the relative abundance of nine of the 10 species that I examined; the exception was the obligate aquatic salamander Siren intermedia. The forest dwelling species took a mean of 4.6 years for populations of these species to recover to pre-burn levels. Prescribed burns also negatively affected Ambystoma tigrinum, A. texanum, and Notophthalmus viridescens, however, their mean time to recover was just 1.6 years and they typically exceeded pre-burn abundance. Conservation management practices should avoid using frequent springtime prescribed burning of wetlands and surrounding upland habitats when pond-breeding salamanders are present.

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