Beirut, Lebanon

Saint - Joseph University
Beirut, Lebanon

Saint Joseph University is a private Catholic research university in Beirut, Lebanon, founded in 1875 by the Jesuits. It ranks as the best to second best university in Lebanon, subsequently among the top academic institutions in all of the Middle East. Its alumni include numerous Lebanese presidents, ministers, philosophers, intellectuals, clerics and beyond. As Lebanon's oldest and main French medium university, while promoting Lebanese culture, admission openly disregards any ethno-religious affiliations, encouraging trilingualism of French, Arabic and English. Additionally, it is known for its university hospital, Hôtel-Dieu de France.The 12,000 students enrollment is organised with 1873 academic staff and 500 personnel distributed in 12 faculties, 24 institutes and schools across 5 campuses in Beirut, with regional university centres in Sidon, Tripoli and Zahlé, as well as one foreign situated in Dubai. The university is the only one in the Middle East to adhere to the European ECTS university academic credits system, yet officially recognised by and in accord with the higher education law of Lebanon. It maintains some 150 various international agreements. Wikipedia.

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Agency: European Commission | Branch: FP7 | Program: CP-FP-SICA | Phase: SiS-2010- | Award Amount: 2.36M | Year: 2011

The overall objective of this proposal is enhancing research cooperation on gender and science between the European Union and the Mediterranean countries. Research cooperation is aimed at better understand the roots of gender inequality in science in the area, taking into account cultural diversities and traditions, and analyse how the Mediterranean countries are addressing this issue. It will deal with gender equality from a twofold perspective: the representation of women in scientific research and technological development and the integration of the gender dimension in research policy. The project will provide state of the art description, data collection and relevant comparative analysis on gender and science in all the Mediterranean countries, focusing on three key themes: statistics on women in science, gender equality policies and research on gender inequalities in science careers. These results will be made accessible to the research community and policy makers via an online database, publishable reports and workshops. With the overall purpose of enhancing networking and steering policy-making on gender and science in the years to come, the project will finally develop recommendations for policy-makers aimed at enhancing the presence of women in scientific research and technological development at all levels and ensuring a better integration of the gender dimension in research policy. The Mediterranean countries included in the proposal are the Mediterranean Partner Countries (MPCs), i.e. the Mediterranean countries included in the list of International Co-operation Partner Countries: Algeria, Egypt, Jordan, Lebanon, Morocco, Palestinian-administered areas, Syrian Arab Republic, Tunisia.

Agency: European Commission | Branch: FP7 | Program: CSA-SA | Phase: INCO.2011-6.2 | Award Amount: 612.18K | Year: 2012

The 30-month LEBIN project gives Lebanon the possibility to improve the research activities of their highest quality in the FP7 thematic priority Health, through twinning activities between one of the leading Lebanon scientific and educational organisations Saint-Joseph University, with their long term partner the Aix-Marseille University , located in Marseille (France). The S&T specialist (inno), an international S&T collaboration expert and experienced FP7 coach and trainer for the scientific organisations, will provide methodological, coaching and training support to the project. Berytech,a Lebanese business incubator, will provide input for alaytical work and health workshops. A coherent development strategy for USJ will be prepared, based on SWOT analysis and on the socio-economic analysis on a Lebanese, regional (Mediterranean) and European level. A joint research plan will be then agreed by the twinned partners and a plan for strengthening of collaboration research links between USJ and other EU research organisations will be set up and implemented. The objective of this proposal is to establish a framework of cooperation between USJ in Lebanon and AMU in France under the umbrella of FP7, INCO- ERA and to offer the USJ students, faculty members of this university and other educational institutions in neighbouring countries the possibility to perform research in adequate levels of HEALTH. This project aims to strengthen cooperation and research capacities of Lebanon prominent research centre, USJ, bringing them at the highest level. It will also include several main types of activities, thus forming a coherent plan for improving the USJ capacities in a number of fields relevant to the FP7 Thematic Priority HEALTH: Twinning activities Large-scale networking & brokerage activities Exchange of researchers and young specialists and organisation of joint events such as summer school and an international conference Training and coaching activit

Tannoury J.,Saint - Joseph University | Abboud B.,Saint - Joseph University
World Journal of Gastroenterology | Year: 2013

At present, the treatment of choice for uncomplicated acute appendicitis in adults continues to be surgical. The inflammation in acute appendicitis may sometimes be enclosed by the patient's own defense mechanisms, by the formation of an inflammatory phlegmon or a circumscribed abscess. The management of these patients is controversial. Immediate appendectomy may be technically demanding. The exploration often ends up in an ileocecal resection or a right-sided hemicolectomy. Recently, the conditions for conservative management of these patients have changed due to the development of computed tomography and ultrasound, which has improved the diagnosis of enclosed inflammation and made drainage of intra-abdominal abscesses easier. New efficient antibiotics have also given new opportunities for nonsurgical treatment of complicated appendicitis. The traditional management of these patients is nonsurgical treatment followed by interval appendectomy to prevent recurrence. The need for interval appendectomy after successful nonsurgical treatment has recently been questioned because the risk of recurrence is relatively small. After successful nonsurgical treatment of an appendiceal mass, the true diagnosis is uncertain in some cases and an underlying diagnosis of cancer or Crohn's disease may be delayed. This report aims at reviewing the treatment options of patients with enclosed appendiceal inflammation, with emphasis on the success rate of nonsurgical treatment, the need for drainage of abscesses, the risk of undetected serious disease, and the need for interval appendectomy to prevent recurrence. © 2013 Baishideng. All rights reserved.

Bou Khalil R.,Saint - Joseph University
Medical Hypotheses | Year: 2012

Macrolides are protein synthesis inhibitors exerting an action on the bacterial ribosome. The ribosomes coded for by the human mitochondrial deoxyribonucleic acid (DNA) are similar to those from bacteria in size and structure. In addition, mitochondria are thought to have originated from a symbiotic relationship between an anaerobic proto-eukaryotic cell that engulfed an aerobic bacterium. Morphological changes of mitochondria have been observed in bipolar disorder and schizophrenia. Manic episodes associated with the use of antimicrobial agents have been described since the discovery of isoniazid. The oxidative stress induced in the neuronal mitochondria is thought to underlie this effect. The inhibition of GSK-3β in the intra-mitochondrial Akt signaling pathway is thought to convey mood stabilizing properties. Rapamycin is a macrolide that, besides its antiepileptic effect, restores the Akt function and inhibits the mTOR pathway which may have an antidepressant effect. Accordingly, it is hypothesized that rapamycin may have mood stabilizing properties. © 2011 Elsevier Ltd.

Our aim was to unveil the cortical neural correlates of osseoperception, i.e. the tactile sensation perceived when loading a bone-anchored implant, by taking oral implants as a model. This was performed in a cross-sectional observational study with 9 volunteering patients and 10 age-matched controls. For each patient, functional magnetic resonance imaging (fRMI) recordings were made during punctate mechanical stimulation of either teeth or osseointegrated implants in the maxillary incisor area. During fMRI recordings, 1 Hz punctate tactile stimuli were applied either on a maxillary left central incisor, canine tooth or central incisor implant. A block design paradigm was used to stimulate, in 9 patients, maxillary left central incisor implants (I21-p) and maxillary left canines (T23-p). In 10 control subjects, maxillary left central incisors and canines (T21-c, T23-c) were stimulated. Random effect group analyses were performed for each stimulated site, and differences in cortical activity elicited when loading teeth or implants were examined using ANOVA. As a group, patients activated somatosensory area S2 bilaterally for both I21 and T23, while controls activated S1 and S2 bilaterally for T21 and T23. At an individual level, S1 was activated by 4/9 implants, mainly on the ipsilateral side. The stimulated implants activated a larger bilateral cortical network outside the somatosensory areas: in parietal, frontal and insular lobes, the main clusters being located in the inferior frontal gyri. Stimulation of T23 in patients resulted in an activation pattern intermediate between that of the implants and that of natural teeth. This study demonstrates that punctate mechanical stimulation of oral implants activates both primary and secondary cortical somatosensory areas. It also suggests that brain plasticity occurs when extracted teeth are replaced by endosseous implants. This cortical activation may represent the underlying mechanism of osseoperception.

Kanaan H.Y.,Saint - Joseph University | Al-Haddad K.,École de Technologie Supérieure of Montreal
IEEE Industrial Electronics Magazine | Year: 2012

Three-phase current-injection rectifiers have been recently ranked among the most attractive ac-to-dc energy conversion topologies required in medium-and high-power applications [3][36]. Their increasing popularity is mainly due to their structural and control simplicity and their high performance in terms of input power factor, current distortion, energy efficiency, and dc voltage regulation. They are actually considered solid competitors of six-switch rectifiers [38][42] and the three-phase/switch/level (Vienna) topologies [42][54] in applications where bidirectional power flow is not requested. The main benefit of the current-injection rectifier remains in the reduced number of high-frequency power semiconductors [two high-frequency insulated gate bipolar transistors (IGBTs) and three fast diodes, compared to six high-frequency IGBTs and six fast diodes for the six-switch rectifier, and three high-frequency IGBTs and 18 fast diodes for © 2011 IEEE.

BACKGROUND:: To determine the anatomical and functional outcomes and possible complications after pars plana vitrectomy (PPV) with silicone oil (SO) tamponade in primary uncomplicated rhegmatogenous retinal detachments. METHODS:: This is a prospective observational study. Overall, 62 consecutive patients who underwent surgical repair by PPV and SO injection for primary uncomplicated rhegmatogenous retinal detachment between January 01, 2006 and April 30, 2012 were followed. In general, PPV was chosen over scleral buckling when a significant cataract or a vitreous hemorrhage prevented adequate fundus visualization. Silicone oil was chosen over gas tamponade in patients living at 1,000 meters above the sea level, where SF6 or C3F8 tamponade could not be performed because of the risk of acute increase of intraocular pressure (IOP). One thousand centistokes SO was used in all eyes. At all visits, patients had a detailed ocular history and thorough bilateral evaluation, including best-corrected visual acuity, anterior segment examination, and IOP measurements by aplanation and fundus examination. Outcomes were assessed at 1 day, 1 week, 1 month, 3 months, 6 months, and every 6 months thereafter. Increased IOP was defined as an IOP of more than 21 mmHg. RESULTS:: Anatomical success rate, final best-corrected visual acuity, IOP elevation, cataract formation, and other complications were the main outcome measures. This study included 62 eyes of 62 patients (41 men and 21 women) that underwent retinal detachment repair by PPV and SO injection. The age at the time of intervention was 57.6 ± 10.5 years (mean ± standard deviation; range, 34–79 years). All patients were whites. Mean follow-up was 24.5 ± 17.3 months (range, 6–70 months). Anatomical success rate defined as retinal reattachment 6 months after SO removal was 93.5%. Final BCVA was improved in 55 eyes (88.7%), with a mean of 4 Snellen lines, unchanged in 5 (8.1%), and worse in 2 eyes (3.2%), with a mean of 3 Snellen lines. Mean duration of SO tamponade was 5.12 ± 2.37 months (range, 2–12 months). From the 30 eyes that were still phakic after vitrectomy, 24 eyes (80.0%) underwent cataract surgery within a period of 7.37 ± 3.00 months (range, 2–13 months). Thirty-five eyes (56.5%) had an increase in IOP during the follow-up period. Thirty-one patients had transient ocular hypertension requiring topical treatment during the immediate postoperative period (one month). Only 1 eye (2.9%) required filtrating drainage surgery for IOP control. No eyes developed optic neuropathy secondary to IOP elevation. CONCLUSION:: Pars plana vitrectomy with SO injection seems to be a safe and efficient surgical approach in the treatment of primary uncomplicated rhegmatogenous retinal detachment in patients living in high altitude (>1,000 m). Also, PPV and SO injection are associated with good anatomical and functional outcomes in our series. Reattachment rates are high, and rates of proliferative vitreoretinopathy are low. Cataract formation and elevated IOP represent frequent but successfully controlled complications. © 2016 by Ophthalmic Communications Society, Inc.

Rami B.K.,Saint - Joseph University
American Journal of Alzheimer's Disease and other Dementias | Year: 2012

Alzheimer's disease (AD) is a neurodegenerative disease with no available disease-modifying drugs. However, it has been postulated that neurovascular damage is a primary occurrence in this disease. Neurovascular damage is the result of the presence of cardiovascular risk factor generating hypoxia, oxidative stress, and metabolic changes that activate the endothelial cells of the brain microvasculature in order to respond to the stress by the development of angiogenesis. This endothelial activation could lead to a secretion of many proinflammatory cytokines and growth factors, such as thrombin. Heparin and related oligosaccharides have been shown to be efficient in the improvement of symptoms of AD. Their efficacy may be limited by their nonselective inhibitory effect of thrombin's activity. Direct thrombin inhibitors, such as dabigatran, might be efficient in the treatment of patients with AD because of their high selectivity for thrombin's activity inhibition while having a safer side effects profile than heparin. © The Author(s) 2012.

Khalil R.B.,Saint - Joseph University
Palliative and Supportive Care | Year: 2012

The aim of this review is to evaluate the current status concerning attitudes, beliefs and/or practices of patients, family members, health professionals and/or caregivers regarding truth disclosure about a cancer diagnosis in the Greater Middle East countries. A search was done via MedLine for all publications related to this review objective. 55 publications were included emanating from Egypt, Iran, Israel, Jordan, Kuwait, Lebanon, Palestine Pakistan, Saudi Arabia, Turkey, and United Arab Emirates. In the Greater Middle East region, a diagnosis of cancer is still mixed with social stigma and misperceptions related to incurability. Physicians conserve a truth disclosure policy in which from one side they respect some of the historical and cultural misperceptions about cancer and accordingly, tell the truth about cancer to one of the family members and from another side acknowledge the patients' right to know the truth and tend to disclose it for him(or her) when possible. Family members and caregivers' attitudes, perceptions and beliefs about telling the truth to the patient seem to be in favor of concealment. Discrepant results concerning physicians' and patients' evaluation of the quality of truth disclosure exist in the literature. Education programs in breaking bad news are lacking in many countries. Finally, the most important and common problem affecting truth disclosure to a patient suffering from cancer is the lack of codes and legislations concerning the patients' rights in an informed consent. Studies, legislations and training programs are needed in this domain in Middle Eastern societies. © Cambridge University Press 2012.

Megarbane H.,Saint Georges Hospital | Megarbane A.,Saint - Joseph University
Orphanet Journal of Rare Diseases | Year: 2011

The IFAP syndrome is a rare X-linked genetic disorder reported in nearly 40 patients. It is characterized by the triad of Ichthyosis Follicularis, Alopecia, and Photophobia from birth. Other features such as short stature, intellectual disability, and seizures may develop in the first few years of life. Skin histopathology is non-specific and consists of dilated hair follicles with keratin plugs extending above the surface of the skin, decreased or absent sebaceous glands, and decreased desmosomes in number and size. The disorder results from mutations in the MBTPS2 gene that impairs cholesterol homeostasis and the ability to cope with endoplasmic reticulum stress. Follicular hyperkeratosis can be treated using topical keratolytics, emollients and urea preparations. A moderate response to acitretin therapy has been noted in some patients. Intensive lubrication of the ocular surface is essential. Life expectancy in patients with IFAP syndrome can vary from death in the neonatal period to normal surviving. Cardiopulmonary complications remain the major cause of death. © 2011 Mégarbané and Mégarbané; licensee BioMed Central Ltd.

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