Gouagna L.C.,Institute Of Recherche Pour Le Developpement Ird |
Bancone G.,University of Rome La Sapienza |
Yao F.,Institute Of Recherche En Science Of La Sante Irss |
Yameogo B.,Institute Of Recherche En Science Of La Sante Irss |
And 5 more authors.
Nature Genetics | Year: 2010
Genetic factors are known to have a role in determining susceptibility to infectious diseases1,2, although it is unclear whether they may also influence host efficiency in transmitting pathogens. We examine variants in HBB that have been shown to be protective against malaria3 and test whether these are associated with the transmission of the parasite from the human host to the Anopheles vector. We conducted cross-sectional malariological surveys on 3,739 human subjects and transmission experiments involving 60 children and 6,446 mosquitoes in Burkina Faso, West Africa. Protective hemoglobins C (HbC, Β6Glu→Lys)4,5 and S (Β6Glu→Val)6,8 are associated with a twofold in vivo (odds ratio 2.17, 95% CI 1.57-3.01, P = 1.0 × 10 -6) and a fourfold ex vivo (odds ratio 4.12, 95% CI 1.90-9.29, P = 7.0 × 10 -5) increase of parasite transmission from the human host to the Anopheles vector. This provides an example of how host genetic variation may influence the transmission dynamics of an infectious disease. © 2010 Nature America, Inc. All rights reserved. Source
Laboratory test features of newly diagnosed adult HIV-Infected patients in Ouagadougou (Burkina Faso) [Profil biologique des patients nouvellement pris en charge pour une infection à VIH à Ouagadougou (Burkina Faso)]
Sagna Y.,Service de Medecine Interne |
Koulidiaty J.,Service de Medecine Interne |
Diallo I.,Service de Medecine Interne |
Sanou A.F.,Service de Medecine Interne |
And 6 more authors.
Medecine et Sante Tropicales | Year: 2014
Objective: In a sub-Saharan African population of adults beginning care for HIV infection, we sought to describe some laboratory features and their correlation with disease progression.Methods: We retrospectively reviewed pretreatment laboratory records of recently diagnosed adults (Elisa test) beginning care at the Internal Medicine department of Yalgado Ouédraogo University Hospital between June 2009 and August 2010. The values have been classified according to WHO standards.Results: During the study period, 177 patients were newly diagnosed as HIV-positive. Among them, 144 (81.4%) had CD4 counts below 350 cells/μL. The mean hemoglobin level was 10.3 ± 2.1 g/dL for women (n = 94) and 11.2 ± 2.8 g/dL for men (n = 67, p = 0.028), and 113 (71.1%) had anemia, 12 of them severe (7.5%). Anemia and lymphopenia were significantly correlated with a low CD4 count (p = 0.001 and 0.003 respectively). Six patients (3.4%) also had type 2 diabetes. Total cholesterol was normal in all patients, and 8 (10.4%) had hypertriglyceridemia.Conclusion: Hematopoietic, glycemic and lipid disorders seem relatively common in untreated black patients with HIV infection. A low CD4 count appears to predict hematopoietic cell deficits. © 2014 John Libbey Eurotext. All rights reserved. Source
Linguissi L.S.G.,University of Ouagadougou |
Nagalo B.M.,University of Ouagadougou |
Bisseye C.,University of Ouagadougou |
Bisseye C.,Universite des Sciences et Techniques de Masuku |
And 7 more authors.
Asian Pacific Journal of Tropical Medicine | Year: 2012
Objective: To evaluate the prevalence of toxoplasmosis and rubella among pregnant women at Ouagadougou in Burkina Faso. Methods: All patient sera were tested for rubella and toxoplasmosis anti-IgG using commercial ELISA kits (Platelia™ Rubella IgG and Platelia™ Toxo IgG). The presence of anti-rubella and anti-toxoplasmosis IgM in serum samples was tested using commercial ELISA kits Platelia Rubella IgM and Platelia Toxo IgM. Results: Among all the pregnant women tested for toxoplasmosis and rubella, their prevalence were 20.3% and 77.0%, respectively. Pregnant women in the age group of 18-25 years showed the highest frequency of anti-toxoplasmosis (34.5%) and anti-rubella IgG (84.6%). The prevalence of anti-toxoplasma and anti-rubella IgG decreased between 2006 and 2008 from 32.7% to 12.1% and 84.6% to 65.0%, respectively. There was no significant association between age and the mean titer of anti-toxoplasmosis IgG among pregnant women. Conclusions: The diagnosis of toxoplasmosis and rubella is necessary in pregnant women in Burkina Faso because of the low immunization coverage rate of rubella and the high level of exposure to these two infections which can be harmful to the newborn if contracted by women before the third trimester of pregnancy. © 2012 Hainan Medical College. Source
Tchelougou D.,University of Ouagadougou |
Tchelougou D.,University of Lome |
Kologo J.K.,British Petroleum |
Kologo J.K.,Center Medical Saint Camille |
And 18 more authors.
International Journal of Hypertension | Year: 2015
Objective. This study aimed to investigate the association between three polymorphisms of renin-angiotensin system and the essential hypertension in the population of Burkina Faso. Methodology. This was a case-control study including 202 cases and 204 matched controls subjects. The polymorphisms were identified by a classical and a real-time PCR. Results. The AGT 235M/T and AT1R 1166A/C polymorphisms were not associated with the hypertension while the genotype frequencies of the ACE I/D polymorphism between patients and controls (DD: 66.83% and 35.78%, ID: 28.22% and 50.98%, II: 4.95% and 13.24%, resp.) were significantly different (p < 10-4). The genotype DD of ACE gene (OR = 3.40, p < 0.0001), the increasing age (OR = 3.83, p < 0.0001), obesity (OR = 4.84, p < 0.0001), dyslipidemia (OR = 3.43, p = 0.021), and alcohol intake (OR = 2.76, p < 0.0001) were identified as the independent risk factors for hypertension by multinomial logistic regression. Conclusion. The DD genotype of the ACE gene is involved in susceptibility to hypertension. Further investigations are needed to better monitor and provide individualized care for hypertensive patients. © 2015 Daméhan Tchelougou et al. Source
Epidemiology, characterization of genotypes of human papillomavirus in a population of women in Ouagadougou [Épidémiologie et caractérisation des génotypes de papillomavirus humain dans une population de femmes Ouagadougou]
Ouedraogo C.M.R.,University of Ouagadougou |
Djigma F.W.,University of Ouagadougou |
Bisseye C.,University of Ouagadougou |
Bisseye C.,Center Medical Saint Camille |
And 20 more authors.
Journal de Gynecologie Obstetrique et Biologie de la Reproduction | Year: 2011
Objectives: This work was carried out in order to determine the prevalence of different HPV genotypes in a population of women attending gynecological consultation. Material and methods: From May to June 2010, cervical samples were obtained from 300 women attending gynecological consultation in two health centers in Ouagadougou. The strains of HPV genotyping was done using the technique of polymerase chain reaction (PCR) followed by reverse hybridization on nitrocellulose strips. Results: Among the 73 women(24.3%) infected with HPV, only 27.4% (20/73) of them were infected with a HPV low risk (BR), the 72.6% (53/73). Other women were infected with at least one high risk HPV (HR). By combining the HPV genotypes found without taking into account the number of infected women, we found a total of 84 HPV among whom we have high-risk HPV : HPV-50'S(26/84 or 31.0%), HPV-18 (12/84 or 14.3%), HPV-16 (9/84 or 10.7%), HPV-30'S (5/84 or 5.9%), HPV-HR (5/84 or 5.9%) and HPV-45 (3/84 or 3.6%) and low-risk HPV: HPV-6 (15/84 or 17.9%) and HPV-BR (9/84 or 10.7%). We have found no HPV-11. Discussion and conclusion: The prevalence of HPV found in our series is comparable to that found in the world. To complete this study, it would be necessary to investigate the prevalence of HPV found in cervical lesions in Burkina Faso. © 2011 Elsevier Masson SAS. Tous droits réservé s. Source