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Daejeon, South Korea

Lee M.H.,Daejeon Health science College | Shon Y.-S.,California State University, Long Beach | Yoon K.-S.,Saimdang Cosmetics Co.
Bulletin of the Korean Chemical Society | Year: 2015

A rapid, sensitive, and selective method involving ultraperformance liquid chromatography-electrospray ionization tandem mass spectrometry (UPLC-ESI-MS/MS) was developed for the qualitative and quantitative analysis of the constituents in a medicinal herbal complex extract (MHCE). The MHCE was obtained from 23 herbs traditionally used in oriental medicines that we have been developed as new therapeutic materials to prevent hair loss and enhance hair growth. The chromatographic analysis of the samples of MHCE was performed on a reversed-phase C18 (10 cm × 2.1 mm, flow rate 0.3 mL/min) column with gradient elution using acetonitrile and water with 0.1% formic acid. Mass spectrometry was performed in the positive ESI mode. The bioactive compounds were detected by selected reaction monitoring (SRM) with UPLC-ESI-MS/MS. All calibration curves of reference compounds showed good linearity (r2 > 0.9964) in the test ranges. The limit of detection and limit of quantification of the method were 0.02 ng/mL and 0.05 ng/mL, respectively. © 2015 Korean Chemical Society, Seoul & Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. Source


Kim M.Y.,Chungnam National University | Choi T.-Y.,Chungnam National University | Kim J.-H.,Gyeongsang National University | Lee J.H.,Chungnam National University | And 6 more authors.
Journal of Dermatological Science | Year: 2010

Background: Melanocyte dendrites serve as the principal conduit for melanosome transfer. The dendrite formation requires actin polymerization mediated by Rho family GTPases including RhoA, Rac1 and Cdc42. Objective: The aim of this study is to investigate and explore the involvement of p38 MAPK in melanocyte dendrite formation. Methods: We transduced melanoma cells with adenovirus harboring the expression cassette for constitutive active form of MKK6, an upstream MAPKK for p38 MAPK. Results: We investigated the effect of melanogenic inducers on melanocyte dendricity, using SK-mel-24 melanoma cells because that this cell line is refractory to several melanogenic inducers in terms of melanogenesis. TPA-induced the phosphorylation of p38 MAPK and the elongation of dendrite length, suggesting that MKK6 may be involved in this process. Overexpression of the constitutive active form of MKK6 resulted in significant elongation of dendrites in the melanoma cell line SK-mel-24. Moreover, overexpression of MKK6 ultimately led to the upregulation of Cdc42 and Rac1, suggesting that MKK6 acts as a crucial upstream signaling molecule for Rho family GTPases. When overexpressed in normal human epidermal melanocytes, MKK6 led also the increase of dendrite length. Conclusion: These results suggest that MKK6 is an authentic regulator for melanocytes dendricity, through the modulation of Rho family GTPases. © 2010 Japanese Society for Investigative Dermatology. Source


Trademark
Saimdang Cosmetics Co. | Date: 2010-04-27

Fabric softeners for laundry use; cosmetic creams; lipsticks; shampoo; badian essential oils for personal use; blushers; eye shadows; cosmetic suntan lotions; foundation creams in the nature of facial creams; perfumes; lavender oil; cosmetic perfumes; beauty mask; cosmetic soaps; dentifrices; shoe polish; polishing wax, namely, floor wax; emery paper, namely, emery boards.


Trademark
Saimdang Cosmetics Co. | Date: 2010-04-27

Fabric softeners for laundry use; cosmetic creams; lipsticks; shampoo; badian essential oils for personal use; blushers; eye shadows; cosmetic suntan lotions; foundation creams in the nature of facial creams; perfumes; lavender oil; cosmetic perfumes; beauty mask; cosmetic soaps; dentifrices; shoe polish; polishing wax, namely, floor wax; emery paper, namely, emery boards.


Trademark
Saimdang Cosmetics Co. | Date: 2015-12-17

Exfoliant cosmetics, Functional cosmetics, Anti-aging cosmetic preparations, Cosmetics for scalp, Cosmetics for massage, Make-up, Cosmetics in the nature of pore tightening packs, Make-up for the body, Body creams, Body cleanser, Toners for the body, Non-foaming cosmetic preparations, Sun creams, not for medicinal use, Cosmetics containing vitamin, Cosmetics using biotechnology, Shower cologne, Sun block cosmetics, Cosmetics in the nature of beauty serums and non-medicated skin serum, Wrinkle-minimizing cosmetic preparations for topical facial use, Cosmetics.

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