Yaizu, Japan
Yaizu, Japan

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Kimura H.,Kyoto University | Yagi Y.,Kyoto University | Ohneda N.,SAIDA FDS Inc. | Odajima H.,SAIDA FDS Inc. | And 2 more authors.
Journal of Labelled Compounds and Radiopharmaceuticals | Year: 2014

Microwave technology has been successfully applied to enhance the effectiveness of radiolabeling reactions. The use of a microwave as a source of heat energy can allow chemical reactions to proceed over much shorter reaction times and in higher yields than they would do under conventional thermal conditions. A microwave reactor developed by Resonance Instrument Inc. (Model 520/521) and CEM (PETWave) has been used exclusively for the synthesis of radiolabeled agents for positron emission tomography by numerous groups throughout the world. In this study, we have developed a novel resonant-type microwave reactor powered by a solid-state device and confirmed that this system can focus microwave power on a small amount of reaction solution. Furthermore, we have demonstrated the rapid and facile radiosynthesis of 16a-[18F] fluoroestradiol, 4-[18F]fluoro-N-[2-(1-methoxyphenyl)-1-piperazinyl]ethyl-N-2-pyridinylbenzamide, and N-succinimidyl 4-[18F] fluorobenzoate using our newly developed microwave reactor. Copyright © 2014 John Wiley & Sons, Ltd.

Yokozawa S.,SAIDA FDS Inc. | Ohneda N.,SAIDA FDS Inc. | Muramatsu K.,SAIDA FDS Inc. | Okamoto T.,SAIDA FDS Inc. | And 9 more authors.
RSC Advances | Year: 2015

Microwave-assisted organic synthesis has many advantages and is widely applied to a variety of reactions. We have developed a new single-mode microwave applicator, specific to continuous flow synthesis, whose main feature is that it generates a uniform electromagnetic field inside its resonant cavity. Two well-known reactions, the Fischer indole synthesis and the Diels-Alder reaction, proceeded very quickly when a solution of substrates was pumped through a helical glass tube reactor inside the resonant cavity, under a pressure of 2.5 MPa. The desired products were obtained in high yields. This compact apparatus constitutes a new method for switching organic synthesis from batch to continuous flow, and enables continuous synthesis of products at a scale of 100 g h-1 or more. © The Royal Society of Chemistry 2015.

Saida FDS Inc. | Date: 2010-09-29

A microwave irradiation apparatus proposed for uniformly treating a large number of samples, includes: an irradiation chamber formed in a rectangular resonant cavity of TM (Transverse Magnetic) 110 mode, of which length of X-axis side is a (a>0), length of Y-axis side is b (b>0) and length of Z-axis side is c (c>0); slits respectively formed on Y-Z plane walls of the irradiation chamber; a transfer sheet entering into the irradiation chamber through the slits and moving along a X-Z plane in the irradiation chamber; and a sample holder disposed on the transfer sheet.

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