Vagdevi H.M.,Sahyadri Science College Autonomous |
Gowdarshivannanavar B.C.,Sahyadri Science College Autonomous
International Journal of ChemTech Research | Year: 2012
A series of 3-substituted Schiff bases of quinazoline-2,4-dione have been synthesized from the reactions of quinazoline-2,4-dione (2) with substituted aromatic aldehydes. The structures of the newly synthesized compounds have been established on the basis of elemental analysis, IR, 1H NMR and mass spectral studies. DPPH inhibition potential and FRAP (Ferric reducing antioxidant power) assay were carried out using in vitro models. All the compounds showed more than 50% inhibition potential against DPPH at IC 50 values between 25-500 μg/mL and most of the compounds showed a dose dependant behavior in FRAP assay.
Sandeep C.,Sahyadri Science College Autonomous |
Padmashali B.,Sahyadri Science College Autonomous |
Kulkarni R.S.,Sahyadri Science College Autonomous
Tetrahedron Letters | Year: 2013
Aromatic cycloimmonium ylides underwent smooth cyclization with electron deficient alkynes in presence of anhydrous K2CO3 in DMF solvent at room temperature to afford substituted indolizines. Ylides have also undergone expected cyclization with ethyl cyanoformate to produce imidazo[1,2-a]pyridines. The structures of these newly synthesized compounds have been confirmed by spectroscopic techniques and X-ray diffraction studies. © 2013 Elsevier Ltd. All rights reserved.
Kekuda T.R.P.,Sahyadri Science College Autonomous |
Vinayaka K.S.,Kuvempu University |
Swathi D.,Sahyadri Science College Autonomous |
Suchitha Y.,Sahyadri Science College Autonomous |
And 2 more authors.
E-Journal of Chemistry | Year: 2011
In the present study, we investigated for the first time mineral composition, total phenol content and antioxidant activity of a foliose macrolichen Everniastrum cirrhatum (Fr.) Hale (Parmeliaceae) from Bhadra wildlife sanctuary, Karnataka, India. Mineral content of the lichen was estimated by Atomic absorption spectrophotometer after acid digestion. The secondary metabolites were detected by thin layer chromatography (TLC) and phytochemical assays. The lichen material was extracted with methanol in soxhlet apparatus. Total phenol content was estimated by folin ciocalteu method. Antioxidant activity was determined by DPPH, Ferric reducing and metal chelating assays. Among the principal elements, calcium was found in high concentration followed by magnesium, potassium and phosphorus. Among trace elements, iron was detected in high amount followed by zinc, manganese and copper. The DPPH radical scavenging activity was found to be dose dependent with an IC50 of 6.73 μg/mL. In ferric reducing assay, the absorbance increased with the concentration of extract suggesting reducing power. The extract exhibited good metal chelating activity with an IC50 value of 29.28 μg/mL. Total phenol content was 101.2 mg tannic acid equivalents per gram of extract. Phytochemical analysis revealed the presence of alkaloids, saponins, tannins and terpenoids. TLC revealed atranorin, salazinic acid and protolichesterinic acid. The lichen can be consumed as a source of minerals required for the body as appreciable amount of minerals has been detected. The marked antioxidant activity may be attributed to the presence of phenol content in the extract. Further studies on isolation of metabolites and their bioactivities are under investigation. © Copyright E-Journal of Chemistry 2004-2011.
Gowrish A.,Sahyadri Science College Autonomous |
Vagdevi H.M.,Sahyadri Science College Autonomous |
Rajashekar H.,Tunga Mahavidyalaya
Journal of Applied Pharmaceutical Science | Year: 2015
Modern civilization is facing hundreds of disorders associated with free radicals. The natural antioxidants from non-edible plants are gaining importance to fight against these disorders. The intention of this study is to evaluate the petroleum ether, chloroform and methanol extracts of roots of Leucas marrubioides Desf. (Lamiaceae) for antioxidant and antitubercular activities. The antioxidant activity of the extracts has been evaluated using DPPH radical scavenging, reducing power and nitric oxide scavenging methods. The results of the study indicated that, methanol extract posses promising DPPH radical scavenging, reducing power and nitric oxide scavenging activity. The petroleum ether and chloroform extracts showed moderate antioxidant activity in all the three models. The antitubercular activity of all the extracts of L. marrubioides have been evaluated against Mycobacterium tuberculosis H73Rv strain using Microplate Alamar Blue Assay (MABA). The activity was documented within MIC range of 0.2 to 100μg/ml. The results of MABA showed that petroleum ether extract exhibited excellent antitubercular activity. The chloroform extract is moderately active, whereas methanol extract is less active against M. tuberculosis. The present investigation suggests that L. marrubioides posses remarkable antioxidant and antitubercular activity. © 2015 A Gowrish et al.
Chandrashekhar C.H.,Sahyadri Science College Autonomous |
Latha K.P.,Sahyadri Science College Autonomous |
Vagdevi H.M.,Sahyadri Science College Autonomous |
Vaidya V.P.,Kuvempu University
Der Pharma Chemica | Year: 2011
Barbitones were synthesized by the condensation of chalcones with barbituric acid. The stuctures of the synthesized compounds assigned on the basis of elemental analysis, IR, 1H NMR and mass spectral studies. All the products were evaluated for their in vitro antimicrobial activity against various strains of bacteria and fungi.
Nunna R.,Acharya Nagarjuna University |
Jayanna N.D.,Sahyadri Science College Autonomous |
Ramachandran D.,Acharya Nagarjuna University
Asian Journal of Chemistry | Year: 2015
A new route has been developed for synthesis of gemfibrozil in good yield with high purity. The obtained gemfibrozil was characterized by using IR, 1H NMR, 13C NMR and mass spectral studies. According to Biopharmaceutical Classification System, gemfibrozil is classified under class-II drugs (low solubility-high permeability) and an antihyperlipidimic. So it's admirable to synthesize the intention molecule in easy and economical way.
Ramamoorthy P.K.T.,Sahyadri Science College Autonomous |
Lakshmanashetty R.H.,Wollega University |
Devidas S.,Sahyadri Science College Autonomous |
Mudduraj V.T.,Sahyadri Science College Autonomous |
Vinayaka K.S.,Kuvempu University
Chiang Mai Journal of Science | Year: 2012
Everniastrum cirrhatum (Fr.) Hale (Parmeliaceae) is a foliose macrolichen which usually grows on the barks of trees in temperate regions. In the present study, we report for the first time antifungal and cytotoxic activity of E. cirrhatum. The dried lichen material was powdered and extracted with methanol using by soxhlet apparatus. Antifungal activity of extract (10-100 mg/ml) was tested against two clinical fungal isolates namely Candida albicans and Cryptococcus neoformans by well-in-agar method. Cytotoxic activity of extract (0 - 1,000 μg/ml) was assessed against the brine shrimp Artemia nauplii. Antifungal activity of methanol extract revealed that the growth of the fungi was affected in a dose dependent manner. The susceptibility to methanol extract was higher in case of C. neoformans. In cytotoxic study, the degree of lethality of extract was found to be concentration dependent. Highest mortality of shrimps (100%) was observed in case of extract concentration 1,000 μg/ml. LC 50 value for extract was found to be 474.06 μg/ml and thus the extract is toxic. Preliminary phytochemical analysis of methanol extract by chemical tests revealed the presence of alkaloids, saponins, tannins and terpenoids. In our study, the extract was potent as it produced marked antifungal and cytotoxic activity which may be attributed to the presence of secondary metabolites. In suitable form, the lichen could be used for the treatment fungal infections and cancer. Further, detailed investigations on active principles in the lichen extract and their bio-efficacy could provide leads to interesting antifungal and cytotoxic or anti-tumor drugs.
Sharadamma K.C.,Provimi India Innovation Center |
Purushotham B.,Provimi India Innovation Center |
Radhakrishna P.M.,Provimi India Innovation Center |
Abhilekha P.M.,Provimi India Innovation Center |
Vagdevi H.M.,Sahyadri Science College Autonomous
Asian Journal of Animal Sciences | Year: 2011
Balanced nutrition is a key element to ensure a happy and healthy life. Trace minerals are very essential nutrients in animal diet. Selenium, like the other trace minerals is necessary to sustain life of canines. Selenium is one of the critical nutritional factors for immune system along with zinc, vitamin E, vitamin B6 and linoleic acid. Adequate selenium is necessary for the normal functioning of the immune system and thyroid gland. Selenium is getting significant consideration for its role in various functions such as anticancer, joint health, skin and coat, immune resistance and antioxidant properties etc. Selenium forms the active center for selenoenzymes that carryout redox reactions such as glutathione peroxidase (GPx), thioredoxin reductase, thyroid hormone deiodinase and so on. Animal studies have shown a beneficial effect of selenium in the prevention of cancer. Selenium deficiency has become increasingly recognized as a practical problem in animal industry. Insufficient selenium intake can cause serious health problems, including Kashin-Beck disease in human beings, which is characterized by the degeneration of the articular cartilage between joints, thyroid disease and a variety of cancers. Selenium supplementation is required to overcome the deficiency symptoms and the bio avail ability of the same depends upon the nature of supplements used. It is generally found that organoselenium compounds have substantially greater bio avail ability than that of inorganic selenium. © 2011 Knowledgia Review, Malaysia.
Shashikumar N.D.,Sahyadri Science College Autonomous
Journal of Chemistry | Year: 2013
A convenient and efficient synthetic method for the preparation of some new α-aminophosphonate derivatives via a one-pot three-component system has been achieved using Amberlite IRC-748 as a recyclable catalyst. This method not only provides an excellent complement for the synthesis of α- aminophosphonates but also avoids the use of hazardous acids or expensive/toxic Lewis acids and harsh reaction conditions. Most of the synthesized compounds (4a-o) exhibited activity against bacteria/fungi strains and moderate DPPH radical scavenging activity. © 2013 Nellisara D. Shashikumar.
PubMed | Sahyadri Science College Autonomous
Type: Journal Article | Journal: Indian journal of pharmaceutical sciences | Year: 2014
Thiophene substituted chalcones (1a-e) were cyclised with thiourea in presence of potassium hydroxide to get 4-substituted-6-(thiophen-2-yl)pyrimidine-2-thiols (2a-e) which were then stirred with methyl iodide to obtain 4-substituted-2-(methylsulfanyl)-6-(thiophen-2-yl)pyrimidines (3a-e). Compounds (3a-e) were refluxed with different N-methylpiperazine and N-phenylpiperazine to afford 4-substituted-2-(4-methylpiperazin-1-yl)-6-(thiophen-2-yl)pyrimidines (4a-e) and 4-substituted-2-(4-phenylpiperazin-1-yl)-6-(thiophen-2-yl)pyrimidines (5a-e). The structures of all the newly synthesised compounds 4b, 4d, 5a and 5b showed good antibacterial activity at 40g/mlconcentration. Compounds 4a, 4d, 4e, 5c and 5e showed significant antifungal activity at 40 g/ml concentration compared with standard drugs.