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Yuvaraj T.C.M.,Sahyadri Science College Auto | Parameshwara Naik P.,Sahyadri Science College Auto | Krishnamurthy G.,Sahyadri Science College Auto | Venkatesh T.V.,Kuvempu University | Chidananda B.,Sahyadri Science College Auto
Der Pharma Chemica | Year: 2014

N-{[2-(pyridin-4-ylmethyl)hydrazinyl]carbonothioyl}thiophene-2-carboxamide and its metal complexes have been synthesized and the structure elucidated by elemental analysis, conductivity measurements, UV-Visible, FT-IR, 1H NMR and thermal analysis. The complexes were soluble in most of the organic solvents and were non-electrolytic in nature. The cobalt and nickel complexes posses tetrahedral geometry while that of copper complex have octahedral geometry. The antimicrobial activities of title compounds have been screened against Gram-positive and Gramnegative bacteria with comparing standard ciprofloxacin as reference. Antifungal activities against two different fungi have been evaluated and compared with Flucanazole as reference. Almost all complexes showed excellent activity against bacteria and fungi strains used. The MIC result showed comparable activity as standard drug. Obtained compounds also subjected to antioxidant activity and they show potent activity when compared with ligand. Source


Deepa J.,Kuvempu University | Parashurama T.R.,Panchavati Research Academy for Nature | Krishnappa M.,Kuvempu University | Nataraja S.,Sahyadri Science College Auto
International Journal of Pharma and Bio Sciences | Year: 2013

The antimicrobial property in the extracts of Blechnum orientale L. has been evaluated on clinically isolated bacterial pathogens such as Staphylococcus aureus, Bacillus subtilis, Salmonella typhi, Mycobacterium luteus, Pseudomonas aeruginosa and Escherichia coli. Also the antifungal activity was tested on Candida albicans and Aspergillus flavus. The pet-ether, chloroform, methanol and aqueous extracts were used for the study of antimicrobial activity by agar well diffusion, micro titre method and tube dilution methods. Results indicated that all the four extracts were effective against E. coli, P. aeruginosa and C. Albicans,. Aqueous extract showed relatively higher zone of inhibition against E. coli, P. aeruginosa and C. albicans while S. aureus, B. subtilis, S. typhi, M. luteus and A. flavus were not found to be sensitive to all the extracts. Source

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