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Minami-rinkan, Japan

Ono K.,University of TokyoTokyo | Ohashi S.,Sagamihara Hospital | Oka H.,University of TokyoTokyo | Kadono Y.,University of TokyoTokyo | And 6 more authors.
Modern Rheumatology | Year: 2016

Objectives: To investigate the effect of bilateral and unilateral joint disease on the Modified Health Assessment Questionnaire (MHAQ) scores and the differences in joint weighting in rheumatoid arthritis patients. Methods: A total of 9212 subjects from the Japanese nationwide cohort database NinJa, 2011, were analyzed. The presence or absence of disease in each joint, including swelling and/or tenderness, was investigated. The correlations between bilateral and unilateral disease in each joint and MHAQ scores were investigated using multivariable logistic regression analysis. Results: The patients’ mean age and disease duration was 63.2 and 12.2 years, respectively. The Disease Activity Score-28 was 3.3. The odds ratios of physical impairment according to the MHAQ using multivariable logistic regression models for bilateral and unilateral joints, respectively, were: shoulder, 4.0 and 1.8; elbow, 2.6 and 1.8; wrist, 1.9 and 1.5; hip, 1.7 and 3.0; knee, 2.6 and 1.9; ankle, 2.3 and 2.0, finger, 1.4 and 1.2; and toe, 1.0 and 1.1. The shoulder, elbow, wrist, knee, and ankle had a significant effect on physical impairment. Conclusions: The MHAQ score was significantly affected by shoulder, elbow, wrist, knee, and ankle joint disease. Furthermore, bilateral disease tended to have a greater effect on physical impairment than unilateral disease. © 2015 Japan College of Rheumatology. Source

Furukawa H.,Clinical Research Center for Allergy and Rheumatology | Oka S.,Clinical Research Center for Allergy and Rheumatology | Takehana K.,Ajinomoto Co. | Muramatsu T.,Ajinomoto Co. | And 6 more authors.
Immunome Research | Year: 2013

Interstitial lung disease (ILD) is frequently associated with collagen diseases, and is designated collagen vascular disease-associated ILD (CVD-ILD) that influences the prognosis of the disease. Acute-onset diffuse ILD (AoDILD) occurs in patients with collagen disease with or without underlying CVD-ILD. The prognosis of AoDILD is quite poor. It has been reported that plasma amino acid profiles are altered in rheumatoid arthritis (RA) patients. Here, we investigated the plasma amino acid profiles to determine whether they may be useful for diagnosing CVD-ILD or AoDILD in collagen disease. Plasma amino acid levels were analyzed using liquid chromatography/electrospray ionization tandem mass spectrometry in 64 RA patients with or without CVD-ILD, and 15 collagen disease patients with AoDILD. By using support vector machine (svm) analysis, the svm index (AA) was generated from amino acid profiles and the svm index (AA, KL6) was from amino acid profiles together with Krebs von den lungen-6 (KL-6). Plasma lysine levels were higher in RA patients with ILD than in those without. The optimized cut-off level of svm index (AA) was determined for CVD-ILD in RA, and the specificity and the sensitivity were 86.8% and 65.4%, respectively. These values for the svm index (AA, KL6) were 81.6% and 88.5%. The plasma methionine and phenylalanine levels were significantly increased in the AoDILD state, whereas Fischer's ratio was decreased. This is the first report of plasma amino acid profiles in CVD-ILD and AoDILD in collagen disease. The svm index (AA, KL6) will be a better marker for diagnosing CVD-ILD in RA than KL-6 alone, though svm index (AA) is not. The plasma amino acid profiles could be a better marker for AoDILD in collagen disease patients. Copyright: © 2013 Furukawa H, et al. Source

Furukawa H.,Clinical Research Center for Allergy and Rheumatology | Furukawa H.,University of Tsukuba | Oka S.,Clinical Research Center for Allergy and Rheumatology | Shimada K.,Sagamihara Hospital | And 3 more authors.
Journal of Human Genetics | Year: 2015

Human leukocyte antigen (HLA) polymorphisms are the most important genetic risk factors for rheumatoid arthritis (RA), a chronic systemic inflammatory disease of unknown etiology. Certain HLA-DRB1 alleles, known as shared epitope (SE) alleles because they have the same amino-acid sequence at positions 70-74, are associated with susceptibility to RA. A gene dosage effect is present for RA-predisposing SE alleles, and protective alleles show epistasis. An important role of amino-acid polymorphisms at positions 11 and 13 of the HLA-DRβ chain was also reported recently. Rheumatoid factor and anticitrullinated peptide antibodies are present in many RA patients. Similar to extra-articular manifestations, the presence of these autoantibodies is also associated with certain DRB1 alleles. Different frequencies of RA risk alleles in different ethnicities explain the varying prevalence of RA in different populations and suggest genetic heterogeneity of RA with regard to phenotype and population subsets. Some drug-induced hypersensitivity reactions due to disease-modifying antirheumatic drugs are also associated with HLA alleles. Understanding the role of HLA as the most important genetic factor relevant to RA susceptibility may help in determining its pathogenesis and pave the way to personalized medicine. © 2015 The Japan Society of Human Genetics All rights reserved. Source

Furukawa H.,Clinical Research Center for Allergy and Rheumatology | Oka S.,Clinical Research Center for Allergy and Rheumatology | Shimada K.,Tokyo Metropolitan Tama Medical Center | Sugii S.,Tokyo Metropolitan Tama Medical Center | And 9 more authors.
Biomarker Insights | Year: 2014

Background: Drug-induced proteinuria can occur in rheumatoid arthritis (RA) patients treated with d-penicillamine, gold salts, or bucillamine (Buc), and represents a drug hypersensitivity reaction. Striking associations of human leukocyte antigen (HLA) alleles with adverse reactions have recently been reported for many drugs. Methods: We investigated the association of HLA class II with Buc-induced proteinuria (BI-Pro) in 485 Japanese RA patients treated with Buc, of whom 25 had developed BI-Pro. Rresults and conclusion: This preliminary study showed a highly significant association of DRB1*08:02 with BI-Pro (P = 1.09 × 10-6, corrected P [Pc] = 1.96 × 10-5, odds ratio [OR] 25.17, 95% confidence interval [CI] 7.98-79.38). DQB1*04:02 was also significantly associated with increased risk of BI-Pro (P = 2.44 × 10-5, Pc = 2.69 × 10-4, OR 10.35, 95%CI 3.99-26.83). These findings provide useful information for promoting personalized medicine for RA. © the authors, publisher and licensee Libertas Academica Limited. Source

Egawa N.,Kyoto University | Egawa N.,Japan Science and Technology Agency | Kitaoka S.,Kyoto University | Kitaoka S.,Japan Science and Technology Agency | And 39 more authors.
Science Translational Medicine | Year: 2013

Our work and the study of Bilican et al. highlight the need for complementary assays to detect subtle phenotypic differences between control and mutant induced pluripotent stem cell lines. Source

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