Sagami Chemical Research Center

Hayakawa, Japan

Sagami Chemical Research Center

Hayakawa, Japan
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Kino T.,Sagami Chemical Research Center | Kino T.,Tokai University | Nagase Y.,Tokai University | Ohtsuka Y.,Sagami Chemical Research Center | And 4 more authors.
Journal of Fluorine Chemistry | Year: 2010

Trifluoromethylation of aromatic and hetero-aromatic compounds by CF3I in the presence of Fe(II) compound, H2O2 and dimethylsulfoxide was investigated. Various trifluoromethylated benzene derivatives, six-membered nitrogen-containing aromatic compounds and five-membered hetero-aromatic compounds were obtained under mild conditions. General orientation of electrophilic substitution of aromatic compounds was observed similarly as reported in other radical trifluoromethylation previously. © 2009 Elsevier B.V. All rights reserved.


Hisamatsu Y.,Nagoya City University | Hisamatsu Y.,Sagami Chemical Research Center | Shirai N.,Nagoya City University | Ikeda S.-I.,Nagoya City University | Odashima K.,Nagoya City University
Organic Letters | Year: 2010

N,N-Di-4-triazolylurea (DTU) has developed as a new ADDA module and DTU forms a stable ADDA·DAAD heterocomplex with 2,7-diamido-1,8-naphthyridine (DAN) (Ks = 2.6 - 105 M-1 in CHCl 3). The Ks value of the complex between DTU and DAN is 100-fold greater than that of the complex between N,N-di-2-pyridylurea and DAN due to replacement of a pyridine ring with a 1,2,3-triazole ring. © 2010 American Chemical Society.


Ohno R.,Sagami Chemical Research Center | Nagaoka M.,Sagami Chemical Research Center | Hirai K.,Sagami Chemical Research Center | Uchida A.,Sagami Chemical Research Center | And 3 more authors.
Journal of Pesticide Science | Year: 2010

In the course of an agrochemical random screening test of 1-alkylpyrazole-4-carboxamide analogs showing herbicidal activity, it was discovered that some 1-alkyl-3-sulfonyloxypyrazole-4-carboxamides exhibited high insecticidal activity. These derivatives were readily synthesized through the reaction of various amines with mixed anhydrides of pyrazole-4-carboxylic acids. All pyrazole-4-carboxamides synthesized were evaluated for insecticidal activity and their structure-activity relationships are discussed. It was found that introduction of a methyl or an ethyl group at the 1-position of the pyrazole ring increased insecticidal activity, in particular, introduction of a methylsulfonyloxy group on the pyrazole ring at the 3-position induced potent activity. The level of activity varied with N-substituents of the carbamoyl group at the 4-position of the pyrazole ring. An α-branched alkyl group, such as an isopropyl or a sec-butyl group on the amide nitrogen atom, demonstrated the highest level of activity. Among the compounds evaluated, N-sec-butyl-1-methyl-3-methylsulfonyloxypyrazole-4-carboxamide showed the highest activity against Nephotettix cincticeps, and exhibited moderate activity against both adults and eggs of Tetranychus urticae. Interestingly, substitution of a cyano group induced a higher level of acaricidal activity, while N-(3-cyanopentan-3-yl)-1-methyl-3-methylsulfonyloxypyrazole-4-carboxamide gave excellent activity against T. urticae as well as N. cincticeps. © Pesticide Science Society of Japan.


Hisamatsu Y.,Sagami Chemical Research Center | Aihara H.,Sagami Chemical Research Center
Chemical Communications | Year: 2010

Molecular tweezers with a 2,4,6-triphenyl-1,3,5-triazine spacer exhibit diverse dimerization through π-π stacking interactions in the solid state, and these dimeric species form highly organized supramolecular networks. © 2010 The Royal Society of Chemistry.


Patent
Sagami Chemical Research Center and Kaken Co. | Date: 2011-03-09

The present invention provides a pyrazole derivative of the general formula (1),


The present invention provides a pyrazole derivative of the general formula (1), which has an excellent efficacy as an active component for a herbicide, an intermediate for the production thereof, processes for the production thereof, and a herbicide containing the derivative as an active ingredient.


A phenyl-substituted1,3,5-triazine compound represented by the general formula (1):^(1) and Ar^(2) independently represent substituted or unsubstituted phenyl, naphthyl or biphenylyl group; R^(1), R^(2) and R^(3) independently represent hydrogen atom or methyl group; X^(1) and X^(2) independently represent substituted or unsubstituted phenylene, naphthylene or pyridylene group; p and q independently represent an integer of 0 to 2; and Ar^(3) and Ar^(4) independently represent substituted or unsubstituted pyridyl or phenyl group. This compound is suitable for an organic electroluminescent device.


PubMed | Sagami Chemical Research Center
Type: Journal Article | Journal: Chemical communications (Cambridge, England) | Year: 2010

Molecular tweezers with a 2,4,6-triphenyl-1,3,5-triazine spacer exhibit diverse dimerization through pi-pi stacking interactions in the solid state, and these dimeric species form highly organized supramolecular networks.

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