Yoshida H.,Saga University |
Hunter C.A.,University of Pennsylvania
Annual Review of Immunology | Year: 2015
Interleukin-27 (IL-27) is a cytokine with strikingly diverse influences on the immune response. Although it was initially linked with the development of Th1 responses, it is now recognized as a potent antagonist of different classes of inflammation through its ability to directly modify CD4+ and CD8+ T cell effector functions, to induce IL-10, and to promote specialized T regulatory cell responses. Although this aspect of IL-27 biology has provided insights into how the immune system prevents hyperactivity in the setting of infectious and autoimmune inflammation, in vaccination and cancer models the stimulatory effects of IL-27 on CD8+ T cell function appear prominent. Additionally, associations between IL-27 and antibody-mediated disease have led to an interest in defining the impact of IL-27 on innate immunity and humoral responses in different disease states. The maturation of this literature has been accompanied by attempts to translate these findings from experimental models into human diseases and by efforts to define where IL-27 might represent a viable therapeutic target. © 2015 by Annual Reviews. All rights reserved. Source
Saga University | Date: 2014-02-17
There is provided a steam power cycle system that permits to perform an appropriate heat exchange between a working fluid that is a non-azeotropic mixture and a heat source, to enhance the performance of the whole system. More specifically, a plurality of condensers are provided so as to be connected to each other in series, and the working fluid in a gas phase from the expander is introduced into the respective condensers. Consequently, the ratio of a low boiling point substance of the working fluid becomes higher toward the posterior condenser, it is possible to make the condensation temperature of the working fluid lower than that of the anterior condenser. It is therefore possible to make the temperature of the working fluid possibly close to the temperature of the low-temperature fluid, thus permitting an effective use of the difference in temperature of the heat source.
Saga University and Denso Corporation | Date: 2012-02-23
An adsorbent contains a carbohydrate having an ether linkage. Alternatively, an adsorbent contains a carbohydrate having a cross-linkage formation produced by a dehydration reaction using a strong acid. In collection of a precious metal using the adsorbent, the adsorbent selectively adsorbs a precious metal dissolved in a solution.
Saga University | Date: 2014-03-07
There is provided a steam power cycle system in which steam power cycles using pure materials as a working fluid is used in a multiple stage to reduce pressure loss in the flow channels in the respective heat exchanger so that the fluid serving as heat sources has been caused to make an effective heat exchange with the working fluid. More specifically, not only that the respective flow channels for the fluid serving as heat sources in the evaporator and the condenser in the respective steam power cycle units are connected in series to each other, but the evaporator and the condenser comprise a cross-flow type heat exchanger and are arranged respectively in a flowing direction of the fluid serving as heat source. Consequently, it is possible to reduce the length of the flow channels to the minimum necessary, simplify the flow channel structure, and reduce the pressure loss.
Cyfuse Biomedical and Saga University | Date: 2013-10-24
Provided is a method for producing a cardiac tissue spheroid or vascular tissue spheroid formed from a mixture of a myocardial cell or smooth muscle cell and at least one type of cell selected from a vascular endothelial cell and fibroblast, and a three dimensional cardiac tissue structure or three dimensional vascular tissue structure which are characterized by combining or laminating said spheroid.