Yoshida H.,Saga University |
Hunter C.A.,University of Pennsylvania
Annual Review of Immunology | Year: 2015
Interleukin-27 (IL-27) is a cytokine with strikingly diverse influences on the immune response. Although it was initially linked with the development of Th1 responses, it is now recognized as a potent antagonist of different classes of inflammation through its ability to directly modify CD4+ and CD8+ T cell effector functions, to induce IL-10, and to promote specialized T regulatory cell responses. Although this aspect of IL-27 biology has provided insights into how the immune system prevents hyperactivity in the setting of infectious and autoimmune inflammation, in vaccination and cancer models the stimulatory effects of IL-27 on CD8+ T cell function appear prominent. Additionally, associations between IL-27 and antibody-mediated disease have led to an interest in defining the impact of IL-27 on innate immunity and humoral responses in different disease states. The maturation of this literature has been accompanied by attempts to translate these findings from experimental models into human diseases and by efforts to define where IL-27 might represent a viable therapeutic target. © 2015 by Annual Reviews. All rights reserved.
Saga University and Cyfuse Biomedical | Date: 2016-01-20
Provided is a method for producing a cardiac tissue spheroid or vascular tissue spheroid formed from a mixture of a myocardial cell or smooth muscle cell and at least one type of cell selected from a vascular endothelial cell and fibroblast, and a three dimensional cardiac tissue structure or three dimensional vascular tissue structure which are characterized by combining or laminating said spheroid.
Saga University and Yutoku Pharmaceutical Industries Co. | Date: 2016-05-04
The present invention addresses the problem of providing an artificial skin preparation which requires no suturing or the like when treating a wound area with a dried collagen vitrigel membrane material as an artificial skin, and also is less likely to cause contamination or the like with an exudate, and is free from the risk of secondary damage by replacement thereof. The artificial skin preparation for solving the problem includes at least an adhesive film, an adhesion-preventing sheet, and a dried collagen vitrigel membrane material in this order, and is characterized in that the adhesion-preventing sheet has a sufficient size for preventing the adhesion of the collagen vitrigel membrane to an adhesive layer of the adhesive film and is attached to the adhesive layer of the adhesive film at a position corresponding to the position of the dried collagen vitrigel membrane material, and the dried collagen vitrigel membrane material is made easily detachable from the adhesion-preventing sheet when the adhesive film is peeled off while fixing and holding the dried collagen vitrigel membrane material on the surface of the adhesion-preventing sheet during attachment.
Shino Test Corporation, Saga University and Kurume University | Date: 2016-04-29
The present invention provides a method and a reagent for measuring periostin contained in a sample with improved accuracy, a method for improving accuracy in measurement of periostin, and a method of testing for pulmonary fibrosis or interstitial pneumonia with improved accuracy. The antibody of the present invention binds to at least one region selected from the group consisting of an EMI region, an R1 region, an R2 region, and an R3 region of periostin or a cleavage product thereof. The method and the reagent for measuring periostin and the method for improving accuracy in periostin measurement of the present invention is characterized by detecting at least one region selected from the group consisting of an EMI region, an R1 region, an R2 region, and an R3 region of periostin. The method of testing for pulmonary fibrosis or interstitial pneumonia of the present invention includes the steps of a) measuring the amount or concentration of periostin in a sample derived from a subject, which measuring includes detecting at least one region selected from the group consisting of an EMI region, an R1 region, an R2 region, and an R3 region of periostin and b) comparing the amount or concentration of the periostin in the sample derived from the subject with an amount or concentration of periostin in a sample derived from a living body not suffering from pulmonary fibrosis and interstitial pneumonia.
Saga University and Nagasaki University | Date: 2016-08-24
There is provided a crack detection system in which a crack can properly be detected from a strain distribution of a part to be detected, as acquired without destroying a coating layer of the part to be detected, by applying heat to the part to be detected of a detection object, and analyzing, by a digital image correlation method, images as taken before and after applying the heat to the coating layer of the part to be detected.After taking the image of the part 51 to be detected of the detection object 50 by the imaging unit 10, the heat is applied by the heating unit, and change of the part to be detected, by heat, is also caused on the other surface side through the outer coating surface of the part to be detected, which is to be moved together with the part to be detected. Accordingly, images of every portions of the coating surface of the part to be detected are taken and the image analysis unit 30 analyzes the images before and after applying the heat to acquire a strain distribution of the part to be detected, so that the crack can be detected based on difference in a state of strain between a place where the crack exist and the other place.Therefore, taking the images of the part to be detected including its coating layer enables the analysis to progress without any problems to detect the crack, without removing the coating layer, thus improving the work efficiency of the detection operation.
Saga University and Nagasaki University | Date: 2014-10-17
There is provided a crack detection system in which a crack can be detected from a strain distribution of a part to be detected of an object. After taking the image of the part to be detected of the detection object by the imaging unit, the heat is applied by the heating unit. Furthermore, image of the part to be detected are taken again and an image analysis unit analyzes the images before and after applying the heat to acquire a strain distribution of the part to be detected, so that the crack can be detected based on difference in a state of strain between a place where the crack exist and the other place. Therefore, taking the images of the part to be detected including its coating layer enables the analysis to progress without removing the coating layer to detect the crack.
Saga University | Date: 2014-03-07
There is provided a steam power cycle system in which steam power cycles using pure materials as a working fluid is used in a multiple stage to reduce pressure loss in the flow channels in the respective heat exchanger so that the fluid serving as heat sources has been caused to make an effective heat exchange with the working fluid. More specifically, not only that the respective flow channels for the fluid serving as heat sources in the evaporator and the condenser in the respective steam power cycle units are connected in series to each other, but the evaporator and the condenser comprise a cross-flow type heat exchanger and are arranged respectively in a flowing direction of the fluid serving as heat source. Consequently, it is possible to reduce the length of the flow channels to the minimum necessary, simplify the flow channel structure, and reduce the pressure loss.
Saga University | Date: 2014-02-17
There is provided a steam power cycle system that permits to perform an appropriate heat exchange between a working fluid that is a non-azeotropic mixture and a heat source, to enhance the performance of the whole system. More specifically, a plurality of condensers are provided so as to be connected to each other in series, and the working fluid in a gas phase from the expander is introduced into the respective condensers. Consequently, the ratio of a low boiling point substance of the working fluid becomes higher toward the posterior condenser, it is possible to make the condensation temperature of the working fluid lower than that of the anterior condenser. It is therefore possible to make the temperature of the working fluid possibly close to the temperature of the low-temperature fluid, thus permitting an effective use of the difference in temperature of the heat source.
Saga University and ARKRAY Inc. | Date: 2016-11-02
Provided is a lung cancer biomarker containing a DDR2 protein or a DDR2 gene, or a mutant thereof, i.e., the following (a), (b) and (c): (a) overexpressed DDR2 protein or DDR2 gene; (b) overexpressed DDR2 protein or DDR2 gene mutant; and (c) DDR2 protein or DDR2 gene mutant.
Saga University | Date: 2014-09-17
There is provided a plasma generation device capable of suppressing arc discharge in which discharge is localized to cause a high temperature, and allowing atmospheric discharge plasma to be stably generated with a high generation efficiency in a low temperature at about a room temperature without being spatially biased. The plasma generation device arranged with a plurality of electrodes facing each other includes a discharge position control unit, which is arranged between each of the plurality of electrodes, and is formed by containing an inverse characteristic material composed of a fluid having polarizability and a property that dielectric constant decreases with an increase in temperature, in a container formed of a dielectric material, wherein the inverse characteristic material is spaced apart from each of the plurality of electrodes.