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Košice, Slovakia

Nagy V.,Safarikiensis University | Baca M.,L Pasteur Teaching Hospital | Boor A.,L Pasteur Teaching Hospital
Bratislava Medical Journal | Year: 2013

The aim of this study was to analyze the results of surgical and conservative treatment of non-refl uxing POM. In the period 2000-2009, 45 children (52 ureters) were treated, the average age was 5.8 months (±10.33), 24 children (26 ureters) by surgery (I) and 21 children (26 ureters) by conservative means (II). The average follow-up period was 73.8 (±32.91) and 30.85 months (±23.1) resp. Urine examination, USG, DTPA99mTc, biochemical testing, micturating cystouretography in all patients were performed. Significant difference was present in the occurrence of hydronephrosis of 0th, 3rd and 4th grade, p<0.01, or p=0.17; next in the occurrence of normal ureter, 0-5 mm and dilated ureter >10 mm, p<0.01; and in the occurrence of normal and prolonged time T 1/2, p<0. The health condition was adjusted in 13 (54.20 %), improved on DTPA99mTc in 5 (20.85 %), non-improved in 3 (12.50 %), deteriorated in 1 (4.15 %) and unknown in 2 (8.3 %) patients. In the IInd group a significant difference was in case of occurrence of hydronephrosis of 0th, 2nd and 3rd grade, (p<0.01, or p=0.037 and p=0.011) and in occurrence of normal ureter, with ureter 0-5 mm and dilated ureter 5-10 mm, p<0. The condition at the end of the follow-up period was assessed DTPA99mTc as adjusted in 11 (52.39 %) patients, improved in 6 (28.57 %), unimproved in 3 (14.28 %) and no patient was assessed as having deteriorated and unknown in 1 (4.76 %). Conclusion: In patients with an impaired separate kidney function, early surgical treatment helps to minimize damage to the kidney function and prevents future complications.

Hijova E.,Safarikiensis University | Soltesova A.,Safarikiensis University
Bratislava Medical Journal | Year: 2013

Objectives: Infl ammatory bowel diseases (IBD) are caused by the failure of immunoregulatory mechanisms due to external environmental factors in genetically predisposed individuals. Probiotics and prebiotics could be used in prevention and therapy of many disorders of gastrointestinal tract including ulcerative colitis. Probiotics are living microorganisms with good tolerability and minimal risk, which confer a health benefi t for the host when administered in adequate amounts. Their effect is closely related to maintaining the natural function of the intestinal fl ora. In this respect, they are indispensable prebiotics to protect or reduce the incidence of infl ammatory lesions in diseases of the digestive tract. Conclusion: Ingestion of probiotics and prebiotics may provide some clues in developing a new class of therapeutic agents for the treatment/prevention of IBD and colitis-associated cancer (CAC) in the future (Tab. 2, Ref. 26). Full Text in PDF www.elis.sk.

Nagy V.,Safarikiensis University | Bober J.,Safarikiensis University | Zavacky P.,Safarikiensis University | Brandebur O.,Safarikiensis University | Svajdler M.,steur University Hospital
Bratislava Medical Journal | Year: 2013

Aim: Describe a patient with multiple recurrences of the primary recurrent liposarcoma. Clinical case: A 60-years-old man complained of weight loss (BMI 18.4) with a palpable huge retroperitoneal tumour, which displaced left kidney, and was confirmed on USG and CT. Laboratory examination showed anaemia and pathological blood tests. Chest X-ray initially showed a negative finding. A complete transperitonealy surgical extirpation of the tumour with left side nephrectomy was performed on June 28, 2007. The tumour mass weight was 1900 g. It was lying on the posterior face of the kidney in diameters 170x120x120 mm, completely capsulated by thin grey-pink capsula with peripheral fat tissue on the section grey-pink, lobulary shaped, in 3/4 parts with central necrotic changes. Histopathologically was confirmed the primary dedifferentiated (non-lipogenous) liposarcoma low grade of malignancy. Nephrectomy specimen was confirmed as age related finding. There was no evidence of positives surgical margins. Despite oncological and surgical treatment, followed repeated recurrence with eight transperitoneal surgeries in the retroperitoneum and abdomen with extirpation of the metastases, left side hemicolectomy, splenectomy and repeated extirpation tumour metastases from abdomen and radix mesenterii. Last tumour weighed 2900 grams. Patient died on January 9, 2011, after the eight surgeries on multiorgans failure due to hemorrhagic shock and persistent atrial fibrilaton by cardiopulmonary insufficiency. As a speciality, he was treated without transfusion because as Jehovah́s witness he refused blood derivates. Conclusion: Despite complex surgical and oncological treatment, the prognosis in patient with recurrent liposarcoma was fatal.

Hijova E.,Safarikiensis University | Szabadosova V.,University of Presov | Strojny L.,Safarikiensis University | Bomba A.,Safarikiensis University
Bratislava Medical Journal | Year: 2014

Background: Natural dietary compounds such as prebiotics modulate microbial composition and could prevent the colon cancer development as potential chemopreventive agent. Objectives: Effect of prebiotic-inulin on biochemical, microbial and chemopreventive markers were examined in Sprague-Dawley rats during experimental chemically dimethylhydrazine induced colon cancer development. Methods: Rats were divided to 3 groups: control group (CG), group with dimethylhydrazine (DMH) and group with DMH and prebiotic (DMH+PRE). The effi cacy of the prebiotic inulin (PRE) on the activities of β-glucuronidase, short chain fatty acids (SCFAs), counts of coliforms and lactobacilli, immunoreactivity of cyclooxygenase-2 (COX-2), transcription nuclear factor kappa beta (NFκB) and inducible nitric oxide synthase (iNOS) in colon tissue were examined. Results: Inulin signifi cantly decreased coliforms counts (p<0.01), increased lactobacilli counts (p<0.001), and decreased activity of β-glucuronidase (p<0.01) in fresh caecal digesta. Butyric and propionic acids concentrations were increased after inulin supplementation in comparison to DMH group. Application of inulin decreased immunoreactivity and numbers of COX-2, NFκB and iNOS positive cells in colon tissue in comparison to DMH group. Conclusion: Inulin suppressed expression observed markers, which play an important role in carcinogenesis and in the infl ammatory process, which predisposes to the use of inulin in the prevention or treatment of infl ammatory bowel disease.

Hijova E.,Safarikiensis University | Chmelarova A.,Safarikiensis University | Bomba A.,Safarikiensis University
Bratislava Medical Journal | Year: 2011

Objectives: This experimental work was designed to investigate the efficacy of prebiotic by itself and in combination with Hyppocastani extractum siccum, and Lini oleum virginale on selected parameters in rats with dimethylhydrazine induced colon cancer. Methods: Rats were randomly divided into 5 experimental groups of 12 rats each. Rats were fed with high fat (HF) diet containing 10 % of fat, supplemented by prebiotic at a dose of 2 % of HF diet itself and in combination with Hyppocastani extractum siccum at a dose of 1 % of diet and Lini oleum virginale at a dose of 2 % of diet. Two weeks after the start of the diet dimethylhydrazine injections in dose 20 mg/kg b.w. were applied (DMH, Merck, DE), two times at week interval. The activity of ß-glucuronidase, concentration of lipid parameters, bile acids and short chain fatty acids were determined. Results: Prebiotic and its combinations with selected substances significantly decreased the activity of bacterial enzyme ß-glucuronidase (p<0.001). Bile acids concentration was significantly decreased (p<0.01) excepting combination of prebiotic with Horse chestnut. Self applied prebiotic decreased (p<0.001) lipids parameters (total cholesterol and triacylglycerols), and enhanced short chain fatty acids production. Conclusion: Prebiotics have protective effect and may be the useful candidate agents for colon cancer prevention and treatment. The application of selected bioactive food components supported the effect of prebiotics.

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