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Hristova K.,Sofia University | Singh R.B.,Halberg Hospital and Research Institute | Fedacko J.,Safaric University | Toda E.,Tokai University | And 6 more authors.
World Heart Journal | Year: 2013

Introduction. Recent evidence shows that chronic heart failure (CHF) is a major cause of morbidity and mortality. The prognosis in CHF may be dependent on cause, severity and presence of risk factors and drug therapy. In the present study, we examine the causes, risk factors, class and oxidative stress among CHF patients. Subjects and methods. Of 127 patients with CHF, 2 were excluded and the remaining 125 patients (Men 61, women 64) with different aetiologies of CHF, and 250 age and sex matched control subjects, were evaluated in this case study. Severity of disease based on the New York Heart Association (NYHA) standards fell within functional classes II to IV. The diagnosis of HF was based on clinical manifestations as well as on echocardiographic heart enlargement. Results. The causes of CHF were; CAD (n=34, 27.2%), hypertensive heart disease (n=10, 8.0%),valvular heart disease (n=40, 32.0%) and idiopathic dilated cardiomyopathy (n=38, 30.4%).Risk factors of HF were; CAD (n=52, 41.6%), hypertension (>140/90mmHg) (n=54, 43.2%), diabetes mellitus (n=12, 9.6%), obesity (n=43, 34.4%) and albuminurea (n=12,9.6%). Echocardiographic ejection fraction was 39.1±8.2% (mean±SD)in the study group, indicating class II-IV heart failure. There was a significant increase in biomarkers of oxidative stress, among HF patients compared to healthy subjects. Conclusions. The findings indicate that HF has become a public health problem. The causes of HF appear to be CAD, cardiomyopathy and valvular heart disease. Severity of CHF, aetiology; CAD and cardiomyopathy appear to be important for increased oxidative stress among these patients. © Nova Science Publishers, Inc.


Fedacko J.,University of P.J. Safarik | Pella D.,University of P.J. Safarik | Fedackova P.,University of P.J. Safarik | Vargova V.,University of P.J. Safarik | And 3 more authors.
Open Nutraceuticals Journal | Year: 2011

Background: Several cardiovascular, neurological and other diseases are associated with coenzyme Q10(CoQ) deficiency. The objective is to evaluate possible benefits of ubiquinone supplementation in cardiovascular diseases and degenerative diseases of the brain. Methods: An internet search in PubMed, Vitasearch, In Circulation. Net, till 2008, discussions with colleagues, own experiences. Results: Ubiquinone (Coenzyme Q10) deficiency has been observed in several cardiovascular and neurological diseases. CoQ10 has strong influence on lipid metabolism, oxidation of blood lipids, vascular inflammation and on the cell membranes of cardiac and arterial cells and neurons. These pathogenetic mechanisms seem to be important in patients with neurological and cardiac disease as well as in brain-heart connection. Its supplementation has several beneficial effects including the stabilisation of atherosclerotic plaque and decreasing the size of myoacardial infarction and the protection of neurons. Antioxidant properties of CoQ10 are responsible for the prevention of many drug side effects. Several studies have suggested the beneficial effect of CoQ10 in neuro-cardiovascular diseases, that will require further confirmation. Adverse effects such as nausea and vomiting may be reduced by using highly bio-available brands, that reduce the oral dosage of COQ. Conclusions: CoQ10 is still in the investigational stages and the list of possible indications related to brain and heart diseases and their linkage, appears to be quite extensive. There is still the need for a number of large, double blind multicenter, randomized, controlled clinical trials, in order to confirm the possible beneficial effects of CoQ10 supplementation in different neurocardiological conditions. © Fedacko et al.


Singh R.B.,Halberg Hospital and Research Institute | Anjum B.,KGMU | Takahashi T.,Fukuoka Womens University | Martirosyan D.M.,Functional Food Center Inc. | And 5 more authors.
World Heart Journal | Year: 2012

Background: The pathways for development of noncommunicable diseases (NCDs) are sedentary behaviour, common dietary habits of the Western world, tobacco use, stress, and alcoholism among individuals and populations with underlying lack of general and health education. However, some experts have observed that poverty is the primary cause of disability and deaths due to NCDs. This study examines the association of social class and social determinants of health as risk factors for deaths due to NCDs. Subjects and methods: Randomly selected death records of 2,222 (1,385 men and 837 women) decedents, aged 25-64 years at time of death, out of 3,034 death records, were studied by verbal autopsy questionnaires, during 1999-2001 from the records at the Municipal Corporation in Moradabad. All the risk factors were assessed by questionnaires which werecompleted with the help of the victim's spouse and a local treating doctor practising in the concerned field. Social classes were assessed, based on attributes of per capita income, occupation, education, housing, and ownership of consumer luxury items in the household. Poverty was considered if the total family income was


Singh R.B.,Halberg Hospital and Research Institute | Fedacko J.,Safaric University | Pella D.,Safaric University | Macejova Z.,Safaric University | And 10 more authors.
Acta Cardiologica | Year: 2011

Background There are few studies detailing the prevalence of prehypertension and hypertension in India. Methods Men and women, over 25 years of age were included. After completion of a dietitian-administered questionnaire followed evaluation by a physician, physical examination and blood pressure measurement. Cross-sectional survey screened 6940 subjects, (3507 men (M), 3433 women (W): 1993-96) from cities located in five corners of India (Kolkata, n = 900; Nagpur, n = 894; Mumbai, n = 1542; Thiruanantpuram, n = 1602; Moradabad, n = 2002). Prehypertension (BP 130-139/85-89 mm Hg) and hypertension (BP ≥ 140/90 mm Hg) were diagnosed according to the European Society of Cardiology criteria. Results Prevalence of prehypertension and hypertension, respectively, was significantly greater in South India (Trivandrum: W 31.5; 31.9%; M 35.1; 35.5%) and West India (Mumbai: W 30.0; 29.1%; M 34.7; 35.6%) compared to North India (Moradabad: W 24.6; 24.5%; M 26.7; 27.0%) and East India (Kolkata: W 20.9; 22.4%; M 23.5; 24.0%). Subjects with prehypertension and hypertension were older, had a higher BMI, central obesity and a sedentary lifestyle. They had a higher salt and alcohol intake, with greater oral contraceptive usage (W). Multivariable logistic regression analysis revealed strong positive associations of hypertension with age, central obesity, BMI, sedentary lifestyle, salt and alcohol intake and oral contraceptive usage (W). Fruit, vegetable and legume intake showed inverse associations, tobacco intake showed none. One in four with hypertension was aware of their diagnosis and of those receiving treatment, one in three had well-controlled hypertension. Conclusions There is little awareness that prehypertension and hypertension are public health issues in India. Ageing population, central obesity, sedentary lifestyle, excessive salt and alcohol, lower fruit, vegetable and legumes intake increase risk for blood pressure elevation.


Singh R.B.,Halberg Hospital and Research Institute | Reddy K.K.,Tirupati University | Fedacko J.,Safaric University | de Meester F.,Tsim Tsoum Institute | And 2 more authors.
Open Nutraceuticals Journal | Year: 2011

Nutritional status has been implicated to be in the pathogenesis of noncommunicable diseases and long-term worldwide survival. In this relevance, the teachings of Bhagwatgita, Upanishads and Indian Vedas appear to be as old as 'Human Civilization'. The dietary formulations concomitant with relevant prescriptions provided in these scriptures appear to be as scientific as observed in cohort studies and intervention trials. These studies confirm the ancient concept reflecting that fruits, vegetables, whole grains, nuts, and milk were quite protective. In this review, the traditional concepts of nutrition to western literature have been duly introduced. © R.B. Singh; Licensee Bentham Open.

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