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Sadat City, Egypt

Salem A.M.S.,Central Metallurgical Research and Development Institute | Harraz F.A.,Central Metallurgical Research and Development Institute | El-Sheikh S.M.,Central Metallurgical Research and Development Institute | Hafez H.S.,Sadat University | And 2 more authors.
RSC Advances | Year: 2015

The electrochemical anodization of a single crystalline silicon in hydrofluoric acid-based solution leads to the formation of porous silicon (PSi) with tunable pore sizes and morphology for a wide range of technological applications. By infiltrating the as-anodized PSi layer with a conducting polymer, new functionalities can be achieved. Herein, we report on the enhancement of the electrical and luminescent properties of a nanohybrid composed of ∼100 nm PSi infiltrated by poly(2-methoxy-5-(2-ethylhexyloxy)-p-phenylenevinylene) (MEH-PPV) via a repeated spin coating technique. Morphological and structural investigations using FE-SEM and XRD on the hybrid nanostructure revealed a successful deposition of MEH-PPV inside the entire porous channels with a low degree of crystallinity. A partial silicon oxide formation was confirmed by FT-IR and XPS measurements. Furthermore, a remarkable increase in the electrical properties was detected by measuring the I-V curves and the electrochemical impedance spectroscopy (EIS). Moreover, a noticeable photoluminescence (PL) spectral enhancement after the MEH-PPV deposition into the PSi was detected. The spectral analyses for the current system indicate the possibility of exciton transfer from PSi to the MEH-PPV polymer. This simple synthetic approach can open new opportunities for the development of hybrid nanostructures of PSi and conducting polymers with potential for optical device applications. © 2015 The Royal Society of Chemistry. Source

Faiz Arshad M.,Shaqra University | Kumar S.,Jamia Hamdard University | Al Rohaimi A.H.,Shaqra University | Hassan A.A.,Shaqra University | And 3 more authors.
Medicinal Chemistry Research | Year: 2015

A series of dihalosubstituted thiocarbamide derivatives (5a-e, 6a-e, 7a-e, and 8a-e) were synthesized as antitubercular agents. The structures of dihalosubstituted thiocarbamide derivatives were established on the basis of IR, 1H, 13C NMR, and mass spectral data. All the compounds were tested in vitro for antimycobacterial activity against Mycobacterium tuberculosis (ATCC-25177) by well-diffusion method and MIC by serial dilution method. Results of the antitubercular screening revealed that some of the compounds showed moderate to good antitubercular activity. Of all the compounds tested, two derivatives viz., 8d and 8e expressed MIC of 25 μg/ml, and one compound 7e showed MIC of 12.5 μg/ml against M. tuberculosis (ATCC-25177). Graphical Abstract: [Figure not available: see fulltext.] © 2014 Springer Science+Business Media New York. Source

Wehaish F.E.,Mansoura University | Elseady Y.Y.,Mansoura University | Saleh R.M.,Mansoura University | Elshal M.F.,Sadat University
Life Science Journal | Year: 2014

Renal dysfunction is a well-known dose-limiting toxicity of the chemotherapeutic drug Cisplatin (CP). CP was also reported to trigger a degenerative process of endothelium that contributes to vascular abnormalities. We aimed to investigate the molecular and biochemical mechanisms contributing to cisplatin-induced vascular damage by evaluating mRNA expression of genes related to leukocytes adhesion (ICAM-1), inflammation (TNF-α and TNFR-1), oxidative stress (HO-1), and basement membrane molecules (desmin, and nephrin). Endothelial damage was evaluated in aorta sections by immunohistochemical staining with von Willebrand factor (vWF). Rats injected with CP (4 mg/kg) i.p. per week for 4 weeks showed significant deterioration in biomarkers of kidney and heart functions, increased oxidative stress (NO and MDA), and decreased antioxidant enzymes of kidney and heart tissue homogenates. CP-injected rats showed also a prominent increase in mRNA of the studied genes compared with control rats. CP-group also showed a significant decrease in vWf expression in aorta sections in comparison to aorta from healthy rats. In conclusion, our data indicated that cisplatin induces cardiovascular changes in addition to renal dysfunction, and that increased leukocytes adhesion, oxidative stress and inflammation may account for these abnormalities. Source

Abou-Easa K.,Kafr El Sheikh University | Abu El-Magd M.,Kafr El Sheikh University | Tousson E.,Tanta University | Hassanin A.,Sadat University | And 2 more authors.
International Journal of Morphology | Year: 2015

Several functional and morphological studies have been conducted on the pineal gland in many mammalian species; however, no published reports are available on the role of pineal gland on the gonadal development before and after eyelids separation in puppies. Therefore, this study aimed to trace the postnatal histo-morphological changes in the pineal gland and gonads of puppies before (2, 10 and 11 days old) and after (25, 35 and 40 days old) eyelids separation in an attempt to investigate the possible role of pineal gland on the gonadal development. In general, the differentiation of pineal cells, interstitial endocrine cells of testes and stromal ovarian cells coincides with the start of eyelids separation in puppies. Histological examination of stained pineal and gonadal slices of puppies after eyelids separation revealed a remarkable differentiation of pinealocytes and testicular interstitial endocrine cells, as well as presence of some evidence of folliculogenesis in ovary. Surprisingly, melatonin receptor (MT1) protein expression levels were significantly increased in the ovaries and testes of puppies after eyelids separation. Moreover, the mRNA and protein expression of AANAT, a ratelimiting enzyme in melatonin biosynthesis, was notably increased in the pineal gland of opened eyes puppies. Our results suggest an increase of melatonin production from the pineal gland of opened eyes puppies and this could play a vital role in the developmental changes observed in the gonads of these puppies. © 2015, Universidad de la Frontera. All rights reserved. Source

Saif M.,Ain Shams University | Shebl M.,Ain Shams University | Nabeel A.I.,Ain Shams University | Shokry R.,Ain Shams University | And 5 more authors.
Sensors and Actuators, B: Chemical | Year: 2015

Abstract Lanthanide doped inorganic nano-phosphor embedded into silica matrix have shown great potential in novel chemical and biological sensor development due to their pure, intense and stable photoluminescence (PL) properties. However, their potential applications in forensic science, especially in latent fingerprint detection in particular, were still unexplored. In this study, we have succeeded in production of high PL, photo-stable and non-toxic x mol% Eu3+:Y2Ti2O7 embedded into silica matrix powder (x mol% Eu3+/Y2Ti2O7 where x = 1.0, 2.0, 4.0 6.0, 10, 15 and 30) using sol-gel method followed by heat treatment. The crystal, morphological, optical and PL properties of the nano-phosphor powders were characterized by X-ray diffraction (XRD), transmission electron microscope (TEM), energy dispersive spectroscopic (EDS), FT-IR and photoluminescence (PL) spectroscopy. Judd-Ofelt (J-O) theory was applied to a series of x mol% Eu3+:Y2Ti2O7 embedded into silica matrix based on their emission spectra. The results of in vivo toxicity test indicated that the prepared nano-phosphor embedded into silica matrix is non-toxic (LD50) for 15 mol% Eu3+ doped powder = 6.26 g/kg). The prepared nano-phosphor was successfully developing in latent fingerprint from various forensic relevant materials, including non-porous and porous surfaces. © 2015 Elsevier B.V. Source

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