Conning Towers-Nautilus Park, CT, United States
Conning Towers-Nautilus Park, CT, United States

Sacred Heart University is a Roman Catholic university located in suburban Fairfield, Connecticut, United States. Sacred Heart was founded in 1963 by the Most Reverend Walter W. Curtis, Bishop of the Diocese of Bridgeport, Connecticut. Sacred Heart University was the first Catholic university in the United States to be staffed by the laity. Dr. John J. Petillo is the current President of the University.SHU is the second largest Catholic university in New England, behind Boston College, and offers more than 40 degree programs to over 7,500 students at the bachelor's, master's and doctoral levels.Sacred Heart is included in The Princeton Review's Best 371 Colleges 2010, the Best 301 Business Schools 2010, as well as U.S. News and World Report's Best Colleges. Wikipedia.


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Pellegrini C.,Sacred Heart University at Connecticut
Melanoma Research | Year: 2017

Genetic susceptibility to cutaneous melanoma has been investigated in Italian high-risk melanoma patients from different geographical regions. CDKN2A, CDK4, and MC1R genes have been screened in most studies, MITF and POT1 were screened in only one study, and none analyzed the TERT promoter. We carried out a mutational analysis of CDKN2A, CDK4 exon 2, POT1 p.S270N, MITF exon 10, MC1R, and the TERT promoter in 106 high-risk patients with familial melanoma (FM) and sporadic multiple primary melanoma (spMPM) from Central Italy and evaluated mutations according to the clinicopathological characteristics of patients and lesions. In FM, CDKN2A mutations were detected in 8.3% of the families, including one undescribed exon 1β mutation (p.T31M), and their prevalence increased with the number of affected relatives within the family. MC1R variants were identified in 65% of the patients and the TERT rs2853669 promoter polymorphism was identified in 58% of the patients. A novel synonymous mutation detected in MITF exon 10 (c.861A>G, p.E287E), although predicted as a splice site mutation by computational tools, could not functionally be confirmed to alter splicing. For spMPM, 3% carried CDKN2A mutations, 79% carried MC1R variants, and 47% carried the TERT rs2853669 promoter polymorphism. MC1R variants were associated with fair skin type and light hair color both in FM and in spMPM, and with a reduction of age at diagnosis in FM patients. Mutations in CDK4 exon 2 and the POT1 p.S270N mutation were not detected. A low frequency of CDKN2A mutations and a high prevalence of MC1R variants characterize high-risk melanoma patients from Central Italy. Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved.


Erdil D.C.,Sacred Heart University at Connecticut
Cluster Computing | Year: 2017

Recent rapid expansion of datasets in big data problems has resulted in data sizes that exceed processing capabilities of available distributed computing power. In other words, we are producing more data than we can process. In addition, further analysis of a dataset collective state may require duplicating, transferring, and distributing to increase the scale of the problem. Orchestrating these steps in large-scale complex systems is non-trivial. One basic technique to help minimize effects of data re-distribution is to use dynamic resource provisioning environments. When the node organization and structure is dynamic and eclectic, provisioning environments require up-to-date information about resource availability. Maintaining freshness of available resource state in centralized or hierarchical scheduling systems imposes a network communication overhead. Centralization also introduces administrative barriers, limiting interoperability. One effective method to improve the extent of self-organization is taking feedback. Based on this feedback, nodes can then alter their behavior to better respond to changing characteristics in dynamic resource provisioning environments. In this article, we present a decentralized scheduling framework that takes feedback from the system, and adjusts its behavior accordingly. Our framework presents an enabling mechanism for self-organization, where each cloud node adapts its behavior based on the feedback. This approach, compared to centralized resource provisioning solutions that exist in current cloud systems, achieves comparable scheduling decisions, with half the packet overhead. We show that by taking advantage of spatial locality with dynamic provisioning, and due to better scheduling decisions with our framework, data processing overhead of big data problems can be reduced by at least 30% in general, and up to 55% in particular resource distributions. This in turn, results in efficient scheduling decisions to provision better resources for big data tasks. © 2017 Springer Science+Business Media New York


Milner K.A.,Sacred Heart University at Connecticut
Oncology nursing forum | Year: 2015

Systematic reviews are a type of literature review in which authors systematically search for, critically appraise, and synthesize evidence from several studies on the same topic (Grant & Booth, 2009). The precise and systematic method differentiates systematic reviews from traditional reviews (Khan, Kunz, Kleijnen, & Antes, 2003). In all types of systematic reviews, a quality assessment is done of the individual studies that meet inclusion criteria. These individual assessments are synthesized, and aggregated results are reported. Systematic reviews are considered the highest level of evidence in evidence-based health care because the reviewers strive to use transparent, rigorous methods that minimize bias.


Treglia G.,Sacred Heart University at Connecticut
Clinical nuclear medicine | Year: 2014

We report a case of thyroid incidentaloma detected by 18F-choline PET/CT. A 66-year-old male patient with a history of prostate cancer underwent a 18F-choline PET/CT for restaging. PET/CT revealed a focal area of increased 18F-choline uptake corresponding to a hypodense nodule in the right lobe of the thyroid. Based on PET/CT findings, the patient underwent a ultrasonography guided fine-needle aspiration biopsy which demonstrated the presence of a benign thyroid nodule.


Lusardi M.M.,Sacred Heart University at Connecticut
Topics in Geriatric Rehabilitation | Year: 2012

Physical therapists expend a great deal of effort to assist older persons to regain the ability to walk independently. While we often use descriptors of gait patterns, assistive device use, level of assistance required, and distance traversed as part of our documentation, quantifying self-selected and fast walking speeds may be the most powerful measure to inform clinical decision making and to assess outcomes of intervention. In this article, we will consider why and how physical therapist should incorporate walking speed data into functional screening, development of plans of care (ie, setting appropriate goals), and assessing efficacy of interventions. We will explore the factors that determine an individual's self-selected walking speed and the importance of assessing if, and how much, an older person is able to increase walking speed for safe community function. We will then present current best evidence about how walking speed typically changes in the later years of life, highlight age-and gender-specific "norms" (ie, typical performance). We will review the converging evidence of key threshold values for walking speed, as they relate to community function, risk of frailty and morbidity, and risk of institutionalization and conclude with a discussion of how such information is used to determine physical therapy prognosis, setting measurable functional goals, documenting efficacy of intervention, and determining need for continued physical therapy care across delivery settings. © 2012 Wolters Kluwer Health | Lippincott Williams &Wilkins.


Lusardi M.M.,Sacred Heart University at Connecticut
Topics in Geriatric Rehabilitation | Year: 2012

Health care professionals use vital signs routinely in caring for older adults. Because vital signs reflect the interaction of many physiological systems, they are effective indicators of general health. Vital signs can be quickly and accurately measured using commonly available equipment. Because normal values have been established, vital signs can be used to identify those individuals who require further evaluation and differential diagnosis to identify possible contributors when vital signs are abnormal, as well as those who would benefit from intervention to restore health and reduce risk of adverse health events. In rehabilitation, vital signs serve as an index of activity and exercise tolerance and are frequently used as an outcome measure to assess efficacy of intervention. This article begins by defining the characteristics of a "good" vital sign, reviews how classical vital signs (heart rate, respiratory rate, blood pressure, and body temperature) are used to guide clinical practice, evaluates how pain has come to be considered the fifth vital sign, and proposes that walking speed meets criteria as an effective vital sign in later life. Walking speed not only is a robust outcome measure but is also a powerful predictor of functional decline, risk of development of frailty, and risk of mortality. Drawing on current best evidence from epidemiologic and clinical research literature, the goal of this article was to motivate readers to adopt measurement of walking speed as a vital sign for all older adults in their care across all physical therapy practice settings. © 2012 Wolters Kluwer Health | Lippincott Williams &Wilkins.


Pierce B.J.,Sacred Heart University at Connecticut | McWilliams S.R.,Sacred Heart University at Connecticut
Integrative and comparative biology | Year: 2014

Fatty-acid composition of fat stores affects exercise performance in a variety of vertebrates although few such studies focus on flying vertebrates such as migratory birds, which are exceptional exercisers. We first discuss the natural variation in quality of fat available in natural foods eaten by migratory birds and their behavioral preferences for specific fatty acids in these foods. We then outline three proposed hypotheses for how dietary fatty acids can affect exercise performance, and some of the evidence to date that pertains to these hypotheses with special emphasis on the exercise performance of migratory birds. In theory, selectively feeding on certain long-chain unsaturated fatty acids may be advantageous because (1) such fatty acids may be metabolized more quickly and may stimulate key facets of aerobic metabolism (fuel hypothesis); (2) such fatty acids may affect composition and key functions of lipid-rich cell membranes (membrane hypothesis); and (3) such fatty acids may directly act as signaling molecules (signal hypothesis). Testing these hypotheses requires cleverly designed experiments that can distinguish between them by demonstrating that certain fatty acids stimulate oxidative capacity, including gene expression and activity of key oxidative enzymes, and that this stimulation changes during exercise. © The Author 2014. Published by Oxford University Press on behalf of the Society for Integrative and Comparative Biology. All rights reserved. For permissions please email: journals.permissions@oup.com.


Kwon S.I.,Sacred Heart University at Connecticut
Korean journal of ophthalmology : KJO | Year: 2011

To assess the macular thickness changes after cataract surgery in diabetic patients using optical coherence tomography (OCT). We retrospectively reviewed the records of 104 diabetic patients who underwent cataract surgery. We examined the changes of macular thickness using OCT before cataract surgery and 1 week, 1-, 2- and 6-months after surgery. The central subfield mean thickness (CSMT) was used to evaluate macular edema which was defined as an increase of CSMT (ΔCSMT) > 30% from the baseline. The association between prior laser treatment or severity of diabetic retinopathy and macular thickness were also analyzed. Macular edema occurred in 19 eyes (18%) from the diabetic group and 63% of macular edema developed at 1 month after surgery. Thirteen (68%) out of 19 eyes with macular edema showed the resolution of macular edema by 6 months after surgery without treatment. ΔCSMT of eyes without a history of laser treatment was statistically greater compared to eyes with a history of laser treatment in at 1- and 2-months after surgery, but was not different than eyes who had laser treatment at 6-months after surgery. The severity of diabetic retinopathy was not significantly correlated to macular edema, but there was statistical difference when patients who had a history of prior laser treatment were excluded. The incidence of macular edema after cataract surgery in diabetic patients was 18%. Its peak incidence was at 1 month post surgery and it resolved spontaneously in 68% of patients by 6 months post surgery. Prior laser treatment might prevent postoperative macular edema until 2 months after cataract surgery in diabetic patients. However, macular edema did not affect the severity of diabetic retinopathy.


Grant
Agency: NSF | Branch: Standard Grant | Program: | Phase: ROBERT NOYCE SCHOLARSHIP PGM | Award Amount: 1.20M | Year: 2016

With funding from the National Science Foundations Robert Noyce Teacher Scholarship program, the Biology and Mathematics Educator Scholarship Project to Prepare Future Secondary Education STEM Teachers will recruit undergraduate majors in biology or mathematics and prepare them to become secondary biology or mathematics teachers. The project will fund 18 scholarships over five years. In this project, Sacred Heart University will collaborate with two high-need school districts to offer preparation that will increase the number of undergraduate biology and mathematics majors entering secondary education. Project activities will include new STEM-specific teacher education curricula and supports that will enable STEM teachers to be effective in a high-need, multicultural classroom. These exceptionally qualified biology and mathematics majors will receive scholarships during their junior and senior years as a STEM major and during one post-baccalaureate year while they earn a Master of Arts in Teaching. The projects objectives are to recruit, retain, and graduate the Noyce scholars; to have them fulfill their teaching commitment; to ensure they benefit from current and innovative best practices that prepare them to teach in high-need STEM classrooms; to provide them with inquiry-based research experiences that improve their understanding and ability to teach the nature of science and research; and to prepare them as effective teachers as evidenced by their students success.

The project will implement enhanced curricular and extracurricular activities to achieve the project goals of increasing both the number and effectiveness of highly qualified biology and mathematics teachers graduating from Sacred Heart University who subsequently teach in high-need secondary school districts. Project activities will develop undergraduate and graduate courses integrating mathematics and science within the framework of STEM education, create research and service-learning opportunities, provide mentoring, and foster the development of a professional teaching identity to increase persistence and avoid the high teacher turnover currently experienced by partnering districts. The institution will develop two new courses to prepare the scholars to break down silos between science and mathematics and to better prepare their secondary students to understand knowledge transfer between settings. This will particularly benefit students in multicultural and high-need classrooms who need multiple perspectives and reinforcement to improve both mathematics and science skills. Additional foci of these courses will be on teaching project-based inquiry learning and grounding instruction in relevant, community-based applications. Participation in STEM research with peer support will improve the scholars understanding of science and mathematics practices and their ability to communicate and teach inquiry-based activities, and service learning will promote community engagement. A long-term mentoring relationship and additional professional identity development will cement the scholars self-confidence and help them persist in a challenging position. The project evaluation and research will generate evidence in support of the new curriculum, as well as scholar participation in STEM research, service learning, mentoring, and professional identity development.


Grant
Agency: NSF | Branch: Standard Grant | Program: | Phase: | Award Amount: 111.25K | Year: 2014

A fundamental aspect of organism-environment interactions is understanding how different physiological and biochemical processes are integrated across different levels of biological organization (molecular, cellular and whole-organism) to support an organisms performance in its natural environment. Migratory birds are excellent model systems for investigating such integrative questions because migratory birds are impressive endurance athletes that use primarily fats to fuel their flights, and diet strongly influences fatty acid composition of stored fat that in turn affects whole-animal energetics during exercise. Reliance on fatty acid oxidation to fuel high-intensity endurance exercise in birds is remarkable in part because it increases oxidative stress which must be dealt with by the birds antioxidant defense system. In fact, human health requires a ready supply of dietary antioxidants to combat the free radicals produced as part of normal metabolism, and much contemporary medical research is focused on understanding how dietary antioxidants promote human health. The primary goals of the two proposed research projects are to experimentally determine how certain essential fatty acids stimulate fat metabolism in exercising birds, how the antioxidant defense system of birds responds to the increased oxidative stress associated with exercise, and how this interaction between fat metabolism and antioxidant defenses depends on changes in seasonal demands during fall and spring migration.

The proposed research builds on the successful collaborative research and teaching programs at a primarily undergraduate (Sacred Heart University) and R1 research (University of Rhode Island) institution. The proposed research will allow URI graduate students to learn fatty acid analysis at SHU, and SHU undergraduates will help URI researchers with field work, captive bird studies, and laboratory analyses for measuring plasma metabolites as indicators of health in wild birds. The two PIs will continue their tradition of training undergraduate and graduate students by utilizing URIs enhancing diversity initiatives and SHUs collaborative with the inner-city Bridgeport (CT) public school system. The proposed research will also strengthen established collaborations with biologists in southern New England working for NGOs such as The Nature Conservancy, Audubon, and local land trusts as well as international collaborations (jointly supported by NSF International Science and Engineering (ISE) Section) with colleagues at the Advance Facility for Avian Research, University of Western Ontario, and Max Plank Institute for Ornithology, Germany. Currently, there is much public interest in dietary antioxidants and how they promote human health. Migratory birds offer an interesting model system for studying the role of dietary antioxidants and fats on fat metabolism during exercise because birds have relatively low rates of free radical production in spite of higher metabolic rates and much higher maximum longevity than mammals of similar body size. In addition, patterns of bird migration have been implicated in the dispersal of disease (e.g. avian flu) and migratory bird populations are declining due to the loss of suitable habitat for stopover sites during their migration. The PIs longstanding collaborative field studies in southern New England guarantees the results will continue to be used for land conservation and management efforts.

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