Saco Pharm. Co.

Madīnat Sittah Uktūbar, Egypt

Saco Pharm. Co.

Madīnat Sittah Uktūbar, Egypt
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Amr A.E.-G.E.,King Saud University | Amr A.E.-G.E.,National Research Center of Egypt | Al-Omar M.A.,King Saud University | Abdalla M.M.,Saco Pharm. Co.
Journal of Computational and Theoretical Nanoscience | Year: 2017

A series of linear and macrocyclic 2,6-disubstituted pyridine derivatives 1-7 were previously prepared and evaluated as analgesic and anticonvulsant agents. Herein these derivatives were screened as anti pancreatic cancer, anti-GIT cancer and mTOR inhibitor activities. The tested compounds were found to have in vivo and in vitro potent anti-pancreatic cancer and anti- GIT cancer activities. The mechanism of action of these compounds was evaluated as mTOR inhibitors. © 2017 American Scientific Publishers.

Abdalla M.M.,Saco Pharm. Co. | Al-Omar M.A.,King Saud University | Al-Salahi R.A.,King Saud University | Amr A.G.E.,King Saud University | And 2 more authors.
International Journal of Biological Macromolecules | Year: 2012

We herein report the anti-Alzheimer activity of some synthesized heterocyclic pyrimidine and thiopyrimidine derivatives fused with steroidal structure. Twenty-one of these compounds were synthesized and conveniently screened for their anti-Alzheimer activities using of Flurbiprofen as the reference drug. Some of these compounds were demonstrated to exhibit remarkable activity and their β-amyloid (Aβ) lowering results as IC50 values reported. © 2012 Elsevier B.V.

Gomha S.M.,Cairo University | Eldebss T.M.A.,Cairo University | Abdulla M.M.,Saco Pharm. Co. | Mayhoub A.S.,Al - Azhar University of Egypt
European Journal of Medicinal Chemistry | Year: 2014

Cellular tumor antigen p53 is crucial for cancer prevention via different mechanisms. E3 ubiquitin-protein ligase HDM2 binds to p53, blocks its ability to activate transcription, and therefore acts as a negative regulator. Blocking p53 binding site on HDM2 was believed to generate efficient antitumor agents. So far, limited scaffolds were reported with HDM2 antagonist activity. Herein, diphenylpyrroles were introduced and evaluated as a novel scaffold in the field of p53 activators. An efficient synthesis of novel 3-heteroaryl-pyrroles is described via reactions of E-3-(dimethylamino)-1-(2-methyl-4,5-diphenyl-1H- pyrrol-3-yl)prop-2-en-1-one or E-1-(2-methyl-4,5-diphenyl-1H-pyrrol-3-yl)-3- morpholinoprop-2-en-1-one with hydrazine hydrate, phenyl hydrazine, hydroxylamine, various heterocyclic amines and active methylene compounds. © 2014 Elsevier Masson SAS. All rights reserved.

Abdalla M.M.,Saco Pharm. Co. | Al-Omar M.A.,King Saud University | Bhat M.A.,King Saud University | Amr A.G.E.,King Saud University | And 2 more authors.
International Journal of Biological Macromolecules | Year: 2012

The aromatase and quinone reductase-2 inhibition of synthesized heterocyclic pyrazole derivatives fused with steroidal structure for chemoprevention of cancer is reported herein. All compounds were interestingly less toxic than the reference drug (Cyproterone ®). The aromatase inhibitory activities of these compounds were much more potent than the lead compound resveratrol, which has an IC 50 of 80μM. In addition, all the compounds displayed potent quinone reductase-2 inhibition. Initially the acute toxicity of the compounds was assayed via the determination of their LD 50. The aromatase and quinone reductase-2 inhibitors resulting from this study have potential value in the treatment and prevention of cancer. © 2012.

Abd-Elzaher M.M.,National Research Center of Egypt | Labib A.A.,National Research Center of Egypt | Mousa H.A.,National Research Center of Egypt | Moustafa S.A.,National Research Center of Egypt | Abdallah M.M.,Saco Pharm. Co.
Research on Chemical Intermediates | Year: 2014

A ferrocenyl ligand 1 was prepared from condensation of 5-methyl-2-furaldehyde with l,l-diacetylferrocene dihydrazone. This ligand forms 1:1 complexes with cobalt(II), nickel(II), copper(II) and zinc(II) 2-5 in good yield. Characterization of the ligand and complexes was carried out using infrared, nuclear magnetic resonance, mass spectra, electronic absorption, magnetic susceptibility, molar conductivity, and elemental analysis. Cytotoxic activity of the prepared ligand and its complexes were tested against different human cancer cell lines. The results suggested that the synthesized compounds were more potent than the comparative standards drugs used in most cases, whereas they had less activity in the others. © 2013 Springer Science+Business Media Dordrecht.

Alanazi A.M.,King Saud University | Al-Omar M.A.,King Saud University | Abdulla M.M.,Saco Pharm. Co. | Amr A.E.G.E.,King Saud University | Amr A.E.G.E.,National Research Center of Egypt
International Journal of Biological Macromolecules | Year: 2013

We herein report the anti-arthritic and immunosuppressive activities of some synthesized substituted terpenoidal structure. Forty-four triterpenoid derivatives 1-21 containing a carboxylic, ester, amide and ketone groups attached to a triterpene moiety were conveniently synthesized and screened for their anti-arthritic and immunosuppressive activities. Synthetic triterpenoidal structures linked to a different function groups seem to be a promising approach in the search for novel leads for potent anti-arthritic and immunosuppressive agents. The detailed synthetic pathways of obtained compounds and anti-arthritic and immunosuppressive activities were reported. © 2013 Elsevier B.V.

Hussain A.A.,Cairo University | Abdulla M.M.,Saco Pharm. Co. | Amr A.E.-G.E.,King Saud University | Amr A.E.-G.E.,National Research Center of Egypt | And 2 more authors.
Russian Journal of Bioorganic Chemistry | Year: 2015

A series of substituted (pyridin-4-yl)phenyl-2-methoxybenzamide and their derivatives were prepared and screened for their anti-inflammatory activities. Initially the acute toxicity of the compounds was assayed via the determination of their LD50. Some of the newly synthesized compounds exhibited better pharmacological and biological responses than the reference controls with low concentrations. The structures of newly synthesized compounds were confirmed by chemical, elemental and spectroscopic evidences. © 2015 Pleiades Publishing, Ltd.

Shawali A.S.,Cairo University | Farghaly T.A.,Cairo University | Hussein S.M.,Cairo University | Abdalla M.M.,Saco Pharm. Co
Archives of Pharmacal Research | Year: 2013

Reactions of hydrazonoyl halides with cyanoacetic hydrazide and its N-arylidene derivatives proceeded site-selectively and afforded the respective pyrazolo[3,4-d]pyridazine and aldehyde N-(1-aryl-3-acetyl-4-cyanopyrazol-5-yl) hydrazone derivatives. The structures of the products were elucidated on the basis of their spectral and elemental analyses. The anti-aggressive activity of the compounds prepared was screened. © 2013 The Pharmaceutical Society of Korea.

PubMed | Saco Pharm. Co., Cairo University, Yueyang Vocational Technical College and King Saud University
Type: Journal Article | Journal: Chemical biology & drug design | Year: 2016

A new series derived from 4-(2-chloroacetyl)-1,2-dihydro-1,5-dimethyl-2-phenyl-3H-pyrazol-3-one was synthesized, characterized and its pharmacological activity toward aromatase enzyme inhibition was screened and compared to the reference native ligand letrozole. The most active compound of the series was 16, showing IC

PubMed | Saco Pharm. Co. and National Research Center of Egypt
Type: Journal Article | Journal: Archiv der Pharmazie | Year: 2016

2-Amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide (1) condensed with carbaldehydes 2a,b to give the respective thienopyrimidines (3a,b), which reacted with phosphoryl chloride and hydrazine hydrate to afford the respective pyrimidinohydrazines (4a,b). Compound 4a condensed with acetophenone under Vilsmeier conditions to afford the formylated pyrazolopyrimidine 6. Condensation of 4a with active methylenes produced the respective pyrazolopyrimidines (7-11). Besides, 4a condensed with succinic anhydride and with phthalic anhydride, yielding the pyrrolidine-2,5-dione 12 and the isoindoline-1,3-dione 13, respectively. Moreover, 4a reacted with isatin to afford the hydrazono-indolin-2-one 14. Structural elucidations for the new thienopyrimidines were based upon compatible analytical and spectroscopic results. Eleven of the new compounds were tested and found active against influenza A neuraminidase virus (H3N2). Compounds 12 and 13 were the most potent.

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