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Madīnat Sittah Uktūbar, Egypt

Abdalla M.M.,Saco Pharm. Co. | Al-Omar M.A.,King Saud University | Bhat M.A.,King Saud University | Amr A.G.E.,King Saud University | And 2 more authors.
International Journal of Biological Macromolecules | Year: 2012

The aromatase and quinone reductase-2 inhibition of synthesized heterocyclic pyrazole derivatives fused with steroidal structure for chemoprevention of cancer is reported herein. All compounds were interestingly less toxic than the reference drug (Cyproterone ®). The aromatase inhibitory activities of these compounds were much more potent than the lead compound resveratrol, which has an IC 50 of 80μM. In addition, all the compounds displayed potent quinone reductase-2 inhibition. Initially the acute toxicity of the compounds was assayed via the determination of their LD 50. The aromatase and quinone reductase-2 inhibitors resulting from this study have potential value in the treatment and prevention of cancer. © 2012.


Abdalla M.M.,Saco Pharm. Co. | Al-Omar M.A.,King Saud University | Al-Salahi R.A.,King Saud University | Amr A.G.E.,King Saud University | And 2 more authors.
International Journal of Biological Macromolecules | Year: 2012

We herein report the anti-Alzheimer activity of some synthesized heterocyclic pyrimidine and thiopyrimidine derivatives fused with steroidal structure. Twenty-one of these compounds were synthesized and conveniently screened for their anti-Alzheimer activities using of Flurbiprofen as the reference drug. Some of these compounds were demonstrated to exhibit remarkable activity and their β-amyloid (Aβ) lowering results as IC50 values reported. © 2012 Elsevier B.V.


Alanazi A.M.,King Saud University | Al-Omar M.A.,King Saud University | Abdulla M.M.,Saco Pharm. Co. | Amr A.E.G.E.,King Saud University | Amr A.E.G.E.,National Research Center of Egypt
International Journal of Biological Macromolecules | Year: 2013

We herein report the anti-arthritic and immunosuppressive activities of some synthesized substituted terpenoidal structure. Forty-four triterpenoid derivatives 1-21 containing a carboxylic, ester, amide and ketone groups attached to a triterpene moiety were conveniently synthesized and screened for their anti-arthritic and immunosuppressive activities. Synthetic triterpenoidal structures linked to a different function groups seem to be a promising approach in the search for novel leads for potent anti-arthritic and immunosuppressive agents. The detailed synthetic pathways of obtained compounds and anti-arthritic and immunosuppressive activities were reported. © 2013 Elsevier B.V.


Hussain A.A.,Cairo University | Abdulla M.M.,Saco Pharm. Co. | Amr A.E.-G.E.,King Saud University | Amr A.E.-G.E.,National Research Center of Egypt | And 2 more authors.
Russian Journal of Bioorganic Chemistry | Year: 2015

A series of substituted (pyridin-4-yl)phenyl-2-methoxybenzamide and their derivatives were prepared and screened for their anti-inflammatory activities. Initially the acute toxicity of the compounds was assayed via the determination of their LD50. Some of the newly synthesized compounds exhibited better pharmacological and biological responses than the reference controls with low concentrations. The structures of newly synthesized compounds were confirmed by chemical, elemental and spectroscopic evidences. © 2015 Pleiades Publishing, Ltd.


Abdulla M.M.,Saco Pharm. Co. | Al-Omar M.A.,King Saud University | Amr A.E.-G.E.,King Saud University | Amr A.E.-G.E.,National Research Center of Egypt
Life Science Journal | Year: 2013

We herein report the monoamine oxidases A and B inhibitors of some synthesized substituted pyrimidines, thiazolopyrimidines and pyrazoles derivatives. Seventeen pyrimidine, thiazolo-pyrimidine, pyrazole, and pyridine derivatives 1-17 containing a carboxamide, ester, amide and ketone groups attached to a heterocyclic moiety synthesized and screened for their monoamine oxidases A and B inhibitors activities. The newly synthesized derivatives containing pyrimidine, thiazolopyrimidine, pyrazole, and pyridine moieties linked with different function groups considered as a lead for potent monoamine oxidases A and B inhibitors agents. The detailed synthetic pathways of obtained compounds and monoamine oxidases A and B inhibitors were reported.

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