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Lokk J.,Huddinge Hospital | Delbari A.,Huddinge Hospital | Delbari A.,Sabzevar University of Medical science
BMC Palliative Care | Year: 2012

Parkinson's disease (PD) is one of the most common neurodegenerative disorders of the elderly population. Few therapeutic options are available for patients with PD requiring palliative care. Treatment of the early stages of PD is entirely different from later stages. During the later stages, the palliative care model is introduced to provide the patient with comfort and support. Early palliative care in PD requires minimization of dyskinesias and decreasing occurrence of motor and non-motor off times in an effort to maximize independent motor function. In the later stages, the focus of treatment shifts to treating the predominant non-motor symptoms and having a more supportive and palliative nature. The purpose of this review is to provide a summary of the palliative care management issues and palliative care management options of end-stage PD patients. © 2012 Lokk and Delbari; licensee BioMed Central Ltd.

Ramshini H.,University of Tehran | mohammad-zadeh M.,Sabzevar University of Medical science | Ebrahim-Habibi A.,Tehran University of Medical Sciences
International Journal of Biological Macromolecules | Year: 2015

Clinical application of curcumin for Alzheimer's disease treatment is severely limited with regard to its poor bioavailability, high rate of metabolism, and instability under neutral condition. In the current study, we designed three compounds in which the diketone moiety of curcumin was replaced by cyclohexanone. In these compounds, the linker length of the molecules was optimal; and substitution of dioxolane for hydroxyl groups on compound 3 should prevent metabolic inactivation. The inhibitory effect of the compounds was investigated against hen egg white lysozyme (HEWL) fibrillation using AFM (atomic force microscope), ThT (thioflavin T) and MTT assay. We found that all three compounds were able to inhibit HEWL aggregation in a dose-dependent manner and inhibit the cytotoxic activity of aggregated HEWL. Docking results demonstrated that the compounds could bind into lysozyme and occupy the whole active site groove. In conclusion, we present chemical analogs of curcumin with various modifications in the spacer and the phenolic rings as improved inhibitors of amyloid aggregation. © 2015 Elsevier B.V.

Abbas Mousavi S.,Golestan University of Medical Sciences | Mortazavi F.,Sabzevar University of Medical science | Chaman R.,Shahroud University of Medical Sciences | Khosravi A.,Shahroud University of Medical Sciences
Oman Medical Journal | Year: 2013

Objective: Cesarean rates in recent decades have been increasing and a number of studies have shown that cesarean increases maternal morbidities. The aim of this study is to compare the quality of life after cesarean and vaginal delivery. Methods: This prospective study was carried out on 356 pregnant women visiting urban health centers in Shahroud City, Northeast Iran, in 2011. The subjects completed the quality of life questionnaire in the third trimester of pregnancy and at 8 weeks postpartum. Results: In primiparas, the mean global QOL scores for the cesarean and vaginal delivery groups were 67.65±12.7 and 72.12±11.8, respectively. Also, the scores for the physical, psychological and social domains of QOL as well as the global score of QOL were higher in the vaginal delivery group than the cesarean group (p<0.05). In the case of primiparas, multiple regression analysis revealed that after adjusting for education, desirability of pregnancy and the General Health Questionnaire score, the delivery type remained as a predictor of the scores for the physical (R2=1.7%; B=-3.826; p=0.031; CI [-7.301, -.350]) and social (R2=2.5%; B=-5.708; p=0.017; CI [-10.392, -1.023]) domains of QOL and the global QOL score (R2=2.6%; B=-4.065; p=0.006; CI [-6.964, -1.164]). While multiparas, there was no relationship between QOL and type of delivery. Conclusion: In this sample of low-risk women, cesarean negatively affected the QOL of primiparas. More studies with larger sample sizes should be conducted to examine the effects of cesarean on QOL in both primiparas and multiparas within a shorter period after delivery. © OMSB, 2013.

The interaction between non-English authors of medical articles and translators can be considered as a key component in perfect rendering of the content. In the era of rapid spread of research findings throughout the world, some researchers with little knowledge of English look for translation and editing services in order to share their findings in the global dialogue of science production. This paper will closely investigate the protocol analysis of an interview with a medical researcher and an intimate translator who has helped him for almost 10 years in translating his articles and research reports into English. The analysis will be classified in two major areas: language and publishing. Further details will be presented in the conference session.

Ranjbar R.,Baqiyatallah Medical Sciences University | Khamesipour F.,Sabzevar University of Medical science | Jonaidi-Jafari N.,Baqiyatallah Medical Sciences University | Rahimi E.,Islamic Azad University
BMC Microbiology | Year: 2016

Background: Up to now, fecal-oral and oral-oral are the most commonly known routes for transmission of H. pylori, therefore, contaminated water can play an important role in transmission of H. pylori to humans. Genotyping using virulence markers of H. pylori is one of the best approaches to study the correlations between H. pylori isolates from different samples. The present research was carried out to study the vacA, cagA, cagE, oipA, iceA and babA2 genotyping and antimicrobial resistance properties of H. pylori isolated from the bottled mineral water samples of Iran. Results: Of 450 samples studied, 8 samples (1.77 %) were contaminated with H. pylori. Brand C of bottled mineral water had the highest prevalence of H. pylori (3.63 %). The bottled mineral water samples of July month had the highest levels of H. pylori-contamination (50 %). H. pylori strains had the highest levels of resistance against metronidazole (62.5 %), erythromycin (62.5 %), clarithromycin (62.5 %), amoxicillin (62.5 %) and trimethoprim (62.5 %). Totally, 12.5 % of strains were resistant to more than 6 antibiotics. VvacAs1a (100 %), vacAm1a (87.5 %), cagA (62.5 %), iceA1 (62.5 %), oipA (25 %), babA2 (25 %) and cagE (37.5 %) were the most commonly detected genotypes. M1as1a (62.5 %), m1as2 (37.5 %), m2s2 (37.5 %) and S1a/cagA+/IceA2/oipA-/babA2-/cagE-(50 %) were the most commonly detected combined genotypes. Conclusions: Contaminated bottled mineral water maybe the sources of virulent and resistant strains H. pylori. Careful monitoring of bottled mineral water production may reduce the risk of H. pylori transmission into the human population. © 2016 Ranjbar et al.

Shirzadeh E.,Sabzevar University of Medical science | Golmohammadi R.,Sabzevar University of Medical science
Iranian Red Crescent Medical Journal | Year: 2012

A 49-year-old Iranian male with diagnosis of ischemic heart disease (IHD) and arterial hypertension (AH) was admitted at Emergency Ward of Vase'ee Hospital of Sabzevar, Iran. As well, the patient had red eye and left eye bleeding. On eye examination, leech infestation was found to be the cause of the eye bleeding. In the endemic regions in a patient presenting red eye and eye bleeding, leech infestation came up to be an important differential diagnosis. Therefore, to prevent leech infestation in endemic regions, local people are advised to be informed more effectively about the necessity to use safe, clean, and filtered drinking water, and a perfect scrutiny for leeches or other sources of infestation that should be undertaken before bathing. © Iranian Red Crescent Medical Journal.

Foji S.,Sabzevar University of Medical science | Tadayonfar M.A.,Sabzevar School of Medical Sciences | Mohsenpour M.,University of Social Welfare and Rehabilitation Sciences | Rakhshani M.H.,Sabzevar University of Medical science
Complementary Therapies in Clinical Practice | Year: 2015

One of the most frequently used methods for the diagnosis and treatment of heart diseases is cardiac catheterization which increases the anxiety level in patients before surgery. In this random clinical study, 62 people undergoing coronary angiography were randomly assigned to experimental and control groups. The necessary data were collected through a hemodynamic variable sheet, the STAI anxiety questionnaire and a pain scale. The experimental group subjects were asked to listen to a Guided Imagery CD for 18min. The mean level of anxiety for the Guided Imagery group after the intervention decreased significantly. The comparison of the means of hemodynamic parameters before and after the intervention showed a small decrease after the intervention, but this reduction was not statistically significant. Moreover, the means of pain as measured by pain scale showed that the control group had slower level of pain but, again, this difference was not statistically significant. © 2015 Elsevier Ltd.

Ghandi S.,Sabzevar University of Medical science | Aflatoonian A.,University of Yazd | Tabibnejad N.,University of Yazd | Moghaddam M.H.S.,Sabzevar University of Medical science
Journal of Assisted Reproduction and Genetics | Year: 2011

Purpose: Comparing the effects of metformin or orlistat on hormone, lipid profile and ovulation status in obese women with polycystic ovary syndrome. Methods: A total of 80 women were prospectively recruited to receive either metformin (n=40) or orlistat (n=40). Weight, BMI, waist, serum LH, total serum testosterone and lipid profile were assessed at baseline and after 3 months. The subjects' ovulatory status was assessed after 3 months. Results: There was no significant difference in ovulation between the two treatment groups (30% vs 15%). Treatment with either drug showed a significant decline in body weight, BMI (Body Mass Index), and waist circumference, but the degree of decline in both groups was the same. Patients who were treated with orlistat, showed a significant reduction in total testosterone and serum lipid. Women in metformin group showed a significant reduction in serum LH. Conclusions: Both metformin and orlistat showed a similar effect on weight loss and ovulation rates. © 2011 Springer Science+Business Media, LLC.

Forghanifard M.M.,Islamic Azad University at Dāmghān | Ardalan Khales S.,Mashhad University of Medical Sciences | Javdani-Mallak A.,Mashhad University of Medical Sciences | Rad A.,Mashhad University of Medical Sciences | And 3 more authors.
Medical Oncology | Year: 2014

Cancer stem cells, as a subgroup of tumor cells, resemble critical properties of embryonic stem cells (ESCs) such as self-renewal and maintenance of stemness state. SALL4 and SOX2 are two main transcription factors involving in maintenance of pluripotency, self-renewal and cell fate decision in ESCs. In this study, we aimed to elucidate the expression levels of these important transcription factors in esophageal squamous cell carcinoma (ESCC) and to reveal their probable roles in maintenance and progression of the disease. The expression level of SALL4 and SOX2 was analyzed in fresh tumoral tissues in comparison with distant tumor-free tissues of 50 ESCC patients by relative comparative real-time PCR. SALL4 and SOX2 were overexpressed in 64 and 32 % of tumor samples, respectively, in significant correlation with each other (p = 0.028). There was a significantly inverse correlation between low level of SALL4 expression and metastasis of tumor cells into the lymph nodes (p = 0.035). Furthermore, co-overexpression of the genes was significantly correlated with the depth of tumor invasion (p = 0.045) and metastasis to the lymph nodes (p = 0.049). SALL4 and SOX2 are co-overexpressed in ESCC and have a significant correlation with invasion and metastasis of the disease. To the best of our knowledge, this is the first report of SALL4 clinical relevance in ESCC to date. The clinical consequences of SALL4-SOX2 association suggest a possible functional interaction between these factors in regulation of ESCC maintenance and aggressiveness and introduce these regulators of stemness state as potentially interesting therapeutic targets to bring new opportunities for onco-therapeutic modalities. © 2014 Springer Science+Business Media New York.

Keramatinia A.,Shahid Beheshti University of Medical Sciences | Mousavi-Jarrahi S.-H.,Mashhad University of Medical Sciences | Hiteh M.,Sabzevar University of Medical science | Mosavi-Jarrahi A.,Shahid Beheshti University of Medical Sciences | And 2 more authors.
Asian Pacific Journal of Cancer Prevention | Year: 2014

Background: The aim of this study was to evaluate trends in incidence of breast cancer in women less than 40 years in Asia. Materials and Methods: Registered cases of female breast cancer age less than 40 years and corresponding person years were ascertained from the CI5plus for 10 registries in Asia for the duration of 1970-2002. Cases were categorized into three age groups: 16-40, 16-29, and 30-40. The 16-40 age group was adjusted to world age population structure. Joinpoint regression analysis was conducted to determine the annual percent of change (APC) and the average annual percent of change (AAPC) for each age group. Results: A total of 23,661 cases of breast cancer occurred in the 10 registries during the 32 years (1970-2002) of follow-up. The overall age adjusted (16-40 group) breast cancer incidence rate increased from 2.28-4.26 cases per 100,000 population corresponding to an AAPC of 2.6% (95%CI 2.1, 3.0). The trend in incidence for the age group 16-29 increased from 0.45-1.07 corresponding to an AAPC of 2.8% (95%CI 1.9, 3.7). In age group 30 to 40, the incidence ranged from 13.3 in year 1970 to 24.8 in year 2002 corresponding to an AAPC of 2.7% (95% CI 2.3, 3.1). There were two statistically significant changing points in the regression line for the age groups 30-40 and 16-40: one point in the year 1975 with an APC of 6.1 (5.1, 7.1), and the other in 1985 with an APC of 0.4% (0.01, 0.8). Conclusions: Our study proved that: 1) the incidence of breast cancer in young women has increased in Asian population during the study period; 2) the rate of increase was very high during the period of 1980-1990.

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