Sabzevar University of Medical science

Sabzevar, Iran

Sabzevar University of Medical science

Sabzevar, Iran

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Naeemipour M.,Sabzevar University of Medical science
Gazzetta Medica Italiana Archivio per le Scienze Mediche | Year: 2017

BACKGROUND: Role of PGCs for producing transgenic chickens has significantly increased recently as a result of their exclusives capabilities. Primordial germ cells (PGCs) isolation in high numbers is the first step toward transgenic chicken production. MethodS: in the present study we used the main methods to purify chicken pGcs including the isolating of pGcs with ammonium chloride-potassium (acK) buffer, Ficoll and percoll density gradient centrifugation, and using the Magnetic cell sorting (MacS). We compared the methods based on the number of pGcs obtained. reSUltS: our results show that Ficoll density gradient centrifugation method is the preferential method. CONCLUSIONS: There is a demand for a more suitable method for more efficient PGCs isolation. © 2016 EDIZIONI MINERVA MEDICA.


Hoseini B.L.,Sabzevar University of Medical science | Moghadam Z.E.,Mashhad University of Medical Sciences | Saeidi M.,Mashhad University of Medical Sciences | Askarieh M.R.,Doctor of Veterinary Medicine DVM | Khademi G.,Mashhad University of Medical Sciences
International Journal of Pediatrics | Year: 2015

Adequate nutrition is essential in early childhood to ensure healthy growth, proper organ formation and function, a strong immune system, and neurological and cognitive development. Child malnutrition - as measured by poor child growth - is an important indicator for monitoring population nutritional status and health. In 2013, about 17%, or 98 million children under five years of age in developing countries were underweight (low weight-for-age according to the WHO child growth standards). Underweight prevalence is highest in the United Nation (UN) region of Southern Asia (30%), followed by Western Africa (21%), Oceania and Eastern Africa (both 19%) and South-Eastern Asia and Middle Africa (both 16%), and Southern Africa 12%. Prevalence below 10% for 2013 is estimated for the UN regions of Eastern, Central and Western Asia, Northern Africa and Latin America and the Caribbean. Childhood malnutrition, including fetal growth restriction, suboptimum breastfeeding, stunting, wasting and Vitamin A and zinc deficiencies, is an underlying cause of death in an estimated 45% of all deaths among children under five years of age.


Lokk J.,Huddinge Hospital | Delbari A.,Huddinge Hospital | Delbari A.,Sabzevar University of Medical science
BMC Palliative Care | Year: 2012

Parkinson's disease (PD) is one of the most common neurodegenerative disorders of the elderly population. Few therapeutic options are available for patients with PD requiring palliative care. Treatment of the early stages of PD is entirely different from later stages. During the later stages, the palliative care model is introduced to provide the patient with comfort and support. Early palliative care in PD requires minimization of dyskinesias and decreasing occurrence of motor and non-motor off times in an effort to maximize independent motor function. In the later stages, the focus of treatment shifts to treating the predominant non-motor symptoms and having a more supportive and palliative nature. The purpose of this review is to provide a summary of the palliative care management issues and palliative care management options of end-stage PD patients. © 2012 Lokk and Delbari; licensee BioMed Central Ltd.


Ramshini H.,University of Tehran | mohammad-zadeh M.,Sabzevar University of Medical science | Ebrahim-Habibi A.,Tehran University of Medical Sciences
International Journal of Biological Macromolecules | Year: 2015

Clinical application of curcumin for Alzheimer's disease treatment is severely limited with regard to its poor bioavailability, high rate of metabolism, and instability under neutral condition. In the current study, we designed three compounds in which the diketone moiety of curcumin was replaced by cyclohexanone. In these compounds, the linker length of the molecules was optimal; and substitution of dioxolane for hydroxyl groups on compound 3 should prevent metabolic inactivation. The inhibitory effect of the compounds was investigated against hen egg white lysozyme (HEWL) fibrillation using AFM (atomic force microscope), ThT (thioflavin T) and MTT assay. We found that all three compounds were able to inhibit HEWL aggregation in a dose-dependent manner and inhibit the cytotoxic activity of aggregated HEWL. Docking results demonstrated that the compounds could bind into lysozyme and occupy the whole active site groove. In conclusion, we present chemical analogs of curcumin with various modifications in the spacer and the phenolic rings as improved inhibitors of amyloid aggregation. © 2015 Elsevier B.V.


The interaction between non-English authors of medical articles and translators can be considered as a key component in perfect rendering of the content. In the era of rapid spread of research findings throughout the world, some researchers with little knowledge of English look for translation and editing services in order to share their findings in the global dialogue of science production. This paper will closely investigate the protocol analysis of an interview with a medical researcher and an intimate translator who has helped him for almost 10 years in translating his articles and research reports into English. The analysis will be classified in two major areas: language and publishing. Further details will be presented in the conference session.


Ranjbar R.,Baqiyatallah Medical Sciences University | Khamesipour F.,Sabzevar University of Medical science | Jonaidi-Jafari N.,Baqiyatallah Medical Sciences University | Rahimi E.,Islamic Azad University
BMC Microbiology | Year: 2016

Background: Up to now, fecal-oral and oral-oral are the most commonly known routes for transmission of H. pylori, therefore, contaminated water can play an important role in transmission of H. pylori to humans. Genotyping using virulence markers of H. pylori is one of the best approaches to study the correlations between H. pylori isolates from different samples. The present research was carried out to study the vacA, cagA, cagE, oipA, iceA and babA2 genotyping and antimicrobial resistance properties of H. pylori isolated from the bottled mineral water samples of Iran. Results: Of 450 samples studied, 8 samples (1.77 %) were contaminated with H. pylori. Brand C of bottled mineral water had the highest prevalence of H. pylori (3.63 %). The bottled mineral water samples of July month had the highest levels of H. pylori-contamination (50 %). H. pylori strains had the highest levels of resistance against metronidazole (62.5 %), erythromycin (62.5 %), clarithromycin (62.5 %), amoxicillin (62.5 %) and trimethoprim (62.5 %). Totally, 12.5 % of strains were resistant to more than 6 antibiotics. VvacAs1a (100 %), vacAm1a (87.5 %), cagA (62.5 %), iceA1 (62.5 %), oipA (25 %), babA2 (25 %) and cagE (37.5 %) were the most commonly detected genotypes. M1as1a (62.5 %), m1as2 (37.5 %), m2s2 (37.5 %) and S1a/cagA+/IceA2/oipA-/babA2-/cagE-(50 %) were the most commonly detected combined genotypes. Conclusions: Contaminated bottled mineral water maybe the sources of virulent and resistant strains H. pylori. Careful monitoring of bottled mineral water production may reduce the risk of H. pylori transmission into the human population. © 2016 Ranjbar et al.


Shirzadeh E.,Sabzevar University of Medical science | Golmohammadi R.,Sabzevar University of Medical science
Iranian Red Crescent Medical Journal | Year: 2012

A 49-year-old Iranian male with diagnosis of ischemic heart disease (IHD) and arterial hypertension (AH) was admitted at Emergency Ward of Vase'ee Hospital of Sabzevar, Iran. As well, the patient had red eye and left eye bleeding. On eye examination, leech infestation was found to be the cause of the eye bleeding. In the endemic regions in a patient presenting red eye and eye bleeding, leech infestation came up to be an important differential diagnosis. Therefore, to prevent leech infestation in endemic regions, local people are advised to be informed more effectively about the necessity to use safe, clean, and filtered drinking water, and a perfect scrutiny for leeches or other sources of infestation that should be undertaken before bathing. © Iranian Red Crescent Medical Journal.


Foji S.,Sabzevar University of Medical science | Tadayonfar M.A.,Sabzevar School of Medical Sciences | Mohsenpour M.,University of Social Welfare and Rehabilitation Sciences | Rakhshani M.H.,Sabzevar University of Medical science
Complementary Therapies in Clinical Practice | Year: 2015

One of the most frequently used methods for the diagnosis and treatment of heart diseases is cardiac catheterization which increases the anxiety level in patients before surgery. In this random clinical study, 62 people undergoing coronary angiography were randomly assigned to experimental and control groups. The necessary data were collected through a hemodynamic variable sheet, the STAI anxiety questionnaire and a pain scale. The experimental group subjects were asked to listen to a Guided Imagery CD for 18min. The mean level of anxiety for the Guided Imagery group after the intervention decreased significantly. The comparison of the means of hemodynamic parameters before and after the intervention showed a small decrease after the intervention, but this reduction was not statistically significant. Moreover, the means of pain as measured by pain scale showed that the control group had slower level of pain but, again, this difference was not statistically significant. © 2015 Elsevier Ltd.


Ghandi S.,Sabzevar University of Medical science | Aflatoonian A.,University of Yazd | Tabibnejad N.,University of Yazd | Moghaddam M.H.S.,Sabzevar University of Medical science
Journal of Assisted Reproduction and Genetics | Year: 2011

Purpose: Comparing the effects of metformin or orlistat on hormone, lipid profile and ovulation status in obese women with polycystic ovary syndrome. Methods: A total of 80 women were prospectively recruited to receive either metformin (n=40) or orlistat (n=40). Weight, BMI, waist, serum LH, total serum testosterone and lipid profile were assessed at baseline and after 3 months. The subjects' ovulatory status was assessed after 3 months. Results: There was no significant difference in ovulation between the two treatment groups (30% vs 15%). Treatment with either drug showed a significant decline in body weight, BMI (Body Mass Index), and waist circumference, but the degree of decline in both groups was the same. Patients who were treated with orlistat, showed a significant reduction in total testosterone and serum lipid. Women in metformin group showed a significant reduction in serum LH. Conclusions: Both metformin and orlistat showed a similar effect on weight loss and ovulation rates. © 2011 Springer Science+Business Media, LLC.


Keramatinia A.,Shahid Beheshti University of Medical Sciences | Mousavi-Jarrahi S.-H.,Mashhad University of Medical Sciences | Hiteh M.,Sabzevar University of Medical science | Mosavi-Jarrahi A.,Shahid Beheshti University of Medical Sciences | And 2 more authors.
Asian Pacific Journal of Cancer Prevention | Year: 2014

Background: The aim of this study was to evaluate trends in incidence of breast cancer in women less than 40 years in Asia. Materials and Methods: Registered cases of female breast cancer age less than 40 years and corresponding person years were ascertained from the CI5plus for 10 registries in Asia for the duration of 1970-2002. Cases were categorized into three age groups: 16-40, 16-29, and 30-40. The 16-40 age group was adjusted to world age population structure. Joinpoint regression analysis was conducted to determine the annual percent of change (APC) and the average annual percent of change (AAPC) for each age group. Results: A total of 23,661 cases of breast cancer occurred in the 10 registries during the 32 years (1970-2002) of follow-up. The overall age adjusted (16-40 group) breast cancer incidence rate increased from 2.28-4.26 cases per 100,000 population corresponding to an AAPC of 2.6% (95%CI 2.1, 3.0). The trend in incidence for the age group 16-29 increased from 0.45-1.07 corresponding to an AAPC of 2.8% (95%CI 1.9, 3.7). In age group 30 to 40, the incidence ranged from 13.3 in year 1970 to 24.8 in year 2002 corresponding to an AAPC of 2.7% (95% CI 2.3, 3.1). There were two statistically significant changing points in the regression line for the age groups 30-40 and 16-40: one point in the year 1975 with an APC of 6.1 (5.1, 7.1), and the other in 1985 with an APC of 0.4% (0.01, 0.8). Conclusions: Our study proved that: 1) the incidence of breast cancer in young women has increased in Asian population during the study period; 2) the rate of increase was very high during the period of 1980-1990.

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