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Gholami O.,Sabzevar School of Medical Sciences | Jeddi-Tehrani M.,Avicenna Research Institute | Iranshahi M.,Mashhad University of Medical Sciences | Zarnani A.H.,Avicenna Research Institute | Ziai S.A.,Shahid Beheshti University of Medical Sciences
Iranian Journal of Pharmaceutical Research | Year: 2013

Umbelliprenin is a prenylated compound, which belongs to the class of sesquiterpene coumarins. It is extracted from dried roots of Ferula szwitsiana collected from the mountains of Golestan forest (Golestan Province, north of Iran). Induction of apoptosis in Jurkat T-CLL cells has been previously shown. In this study, effect of umbelliprenin on proapoptotic caspases (caspase-8 and -9) and antiapoptotic Bcl-2 family protein was studied. Jurkat cells were incubated with umbelliprenin. Cells were then lysed and activation of proteins was studied by Western blot analysis. In this study, we showed that umbelliprenin activates intrinsic and extrinsic pathways of apoptosis by the activation of caspase-8 and -9 respectively. Inhibition of Bcl-2 was also shown. In conclusion, umbelliprenin induced apoptosis in Jurkat cells through caspase-dependent apoptosis pathway. © 2013 by School of Pharmacy.


Foji S.,Sabzevar University of Medical science | Tadayonfar M.A.,Sabzevar School of Medical Sciences | Mohsenpour M.,University of Social Welfare and Rehabilitation Sciences | Rakhshani M.H.,Sabzevar University of Medical science
Complementary Therapies in Clinical Practice | Year: 2015

One of the most frequently used methods for the diagnosis and treatment of heart diseases is cardiac catheterization which increases the anxiety level in patients before surgery. In this random clinical study, 62 people undergoing coronary angiography were randomly assigned to experimental and control groups. The necessary data were collected through a hemodynamic variable sheet, the STAI anxiety questionnaire and a pain scale. The experimental group subjects were asked to listen to a Guided Imagery CD for 18min. The mean level of anxiety for the Guided Imagery group after the intervention decreased significantly. The comparison of the means of hemodynamic parameters before and after the intervention showed a small decrease after the intervention, but this reduction was not statistically significant. Moreover, the means of pain as measured by pain scale showed that the control group had slower level of pain but, again, this difference was not statistically significant. © 2015 Elsevier Ltd.


Mortazavi F.,Sabzevar School of Medical Sciences | Mousavi S.A.,Golestan University of Medical Sciences | Chaman R.,Yasuj University of Medical Sciences | Khosravi A.,Shahroud University of Medical Sciences
Iranian Red Crescent Medical Journal | Year: 2014

Background:: One of the elements of the broadening focus of health care beyond its traditional and restricted concept has been the increasing adoption quality of life approach to health care research and practice. Objectives:: To investigate the QOL of women in the third trimester of pregnancy and at 8 weeks postpartum and factors associated with the overall QOL. Materials and Methods:: Three hundred and fifty seven pregnant women attending urban health centers in Shahroud city, located in Northeast of Iran, completed the World Health Organization Quality of Life questionnaire (WHOQOL)-BREF and General Health Questionnaire (GHQ28) in the third trimester of pregnancy and at 8 weeks postpartum. Also, breastfeeding difficulties were assessed at 4 weeks postpartum. Statistical analysis was performed using SPSS 18 for descriptive statistics, paired t-test, linear regression and multiple regression analysis. Results:: There were significant differences between the ante-and postnatal periods in mean scores in the physical (P < 0.001) and social relationship (P = 0.033) aspects of QOL. Multiple regression analysis revealed that factor adversely affected the global score of the QOL in the antenatal period was antepartum psychological disorders. Factors that adversely affected the global score of QOL in the postnatal period were postpartum psychological disorders, breastfeeding difficulties, multiparity, higher pregnancy weight gain, and cesarean. Conclusions:: Results indicated that in this low risk group of women physical health and social relationship improved from pregnancy to postpartum. Interventions to promote psychological status during pregnancy and early postpartum should be designed. © 2014, Iranian Red Crescent Medical Journal; Published by Kowsar Corp.


Jafari-Koshki T.,Sabzevar School of Medical Sciences | Arsang-Jang S.,Qom University of Medical Sciences | Raei M.,Kermanshah University of Medical Sciences
International Journal of Tuberculosis and Lung Disease | Year: 2015

Setting: Assessing tuberculosis (TB) distribution in regions over time is essential for health officials to have a proper understanding of current status, determine highrisk areas, and improve case management and resource allocation. Objective: To evaluate spatial distribution and trends in the risk of smear-positive Mycobacterium tuberculosis in Iran during 2001-2012 using spatiotemporal models. Design: Overall and province-specific trends in TB risk were estimated using a Bayesian spatiotemporal model. We obtained Bayesian posterior probabilities to test the hypothesis of the relative risk (RR) being equal to 1 and the significance of TB trends in each province. Results: Estimated countrywide trends declined at a rate of almost 3% per decade. The RR was the highest in the provinces of Sistan and Baluchestan, followed by Golestan, Khorasan-Razavi, Hormozgan, Qom, Guilan and South Khorasan. Upward temporal trends were observed in nine provinces. Conclusion: TB risk was generally high in provinces bordering high TB burden countries; population movements from high-risk provinces and adjacent countries appear to be the main challenge to TB control. Nevertheless, the declining risk pattern in these provinces indicates good, but inadequate, progress with TB control. Different health policies according to TB risk and trend are required for each province. © 2015 The Union.


Shamsara J.,Mashhad University of Medical Sciences | Shahir-Sadr A.,Sabzevar School of Medical Sciences
Iranian Journal of Pharmaceutical Research | Year: 2016

Design of selective cyclooxygenase-2 (COX-2) inhibitors is still a challenging task because of active site similarities between COX isoenzymes. To help with this issue, we tried to generate a 3D-QSAR (3 dimensional quantitative structure activity relationships) model that might reflect the essential features of COX-2 active sites. Compounds in a series of resveratrol derivatives inhibitors with reported biological activity against COX-2 were used to construct a predictive comparative molecular similarity indices (CoMSIA) model. A CoMSIA model with acceptable internal and external predictability was developed and employed to design new not yet synthesized molecules with improved activity and selectivity toward COX-2. Finally, molecular docking of the inhibitors in COX-2 active site demonstrated the possible ability of proposed compounds to inhibit COX-2, selectively. © 2016 by School of Pharmacy.


Amin B.,Sabzevar School of Medical Sciences | Hosseinzadeh H.,Mashhad University of Medical Sciences
Planta Medica | Year: 2015

For many centuries, seeds of Nigella sativa (black cumin), a dicotyledon of the Ranunculaceae family, have been used as a seasoning spice and food additive in the Middle East and Mediterranean areas. Traditionally, the plant is used for asthma, hypertension, diabetes, inflammation, cough, bronchitis, headache, eczema, fever, dizziness, and gastrointestinal disturbances. The literature regarding the biological activities of seeds of this plant is extensive, citing bronchodilative, anti-inflammatory, antinociceptive, antibacterial, hypotensive, hypolipidemic, cytotoxic, antidiabetic, and hepatoprotective effects. The active ingredients of N. sativa are mainly concentrated in the fixed or essential oil of seeds, which are responsible for most health benefits. This review will provide all updated reported activities of this plant with an emphasis on the antinociceptive and anti-inflammatory effects. Results of various studies have demonstrated that the oil, extracts, and their active ingredients, in particular, thymoquinone, possess antinociceptive and anti-inflammatory effects, supporting the common folk perception of N. Sativa as a potent analgesic and anti-inflammatory agent. Many protective properties are attributed to reproducible radical scavenging activity as well as an interaction with numerous molecular targets involved in inflammation, including proinflammatory enzymes and cytokines. However, there is a need for further investigations to find out the precise mechanisms responsible for the antinociceptive and anti-inflammatory effects of this plant and its active constituents. Copyright © 2015, Georg Thieme Verlag KG. All rights reserved.


Amin B.,Sabzevar School of Medical Sciences | Abnous K.,Mashhad University of Medical Sciences | Motamedshariaty V.,Mashhad University of Medical Sciences | Hosseinzadeh H.,Mashhad University of Medical Sciences
Anais da Academia Brasileira de Ciencias | Year: 2014

In our previous study, the ethanolic and aqueous extracts of Crocus sativus elicited antinociceptive effects in the chronic constriction injury (CCI) model of neuropathic pain. In this study, we explored anti-inflammatory, anti-oxidant and anti-apoptotic effects of such extracts in CCI animals. A total of 72 animals were divided as vehicle-treated CCI rats, sham group, CCI animals treated with the effective dose of aqueous and ethanolic extracts (200 mg/kg, i.p.). The lumbar spinal cord levels of proinflammatory cytokines including tumor necrosis factor α (TNF-α), interleukin-1β (IL-1β) and interleukin 6 (IL-6), were evaluated at days 3 and 7 after CCI (n=3, for each group). The apoptotic protein changes were evaluated at days 3 and 7 by western blotting. Oxidative stress markers including malondialdehyde (MDA) and glutathione reduced (GSH), were measured on day 7 after CCI. Inflammatory cytokines levels increased in CCI animals on days 3 and 7, which were suppressed by both extracts. The ratio of Bax/ Bcl2 was elevated on day 3 but not on day 7, in CCI animals as compared to sham operated animals and decreased following treatment with both extracts at this time. Both extracts attenuated MDA and increased GSH levels in CCI animals. It may be concluded that saffron alleviates neuropathic pain, at least in part, through attenuation of proinflammatory cytokines, antioxidant activity and apoptotic pathways. © 2014 Academia Brasileira de Ciencias. All Rights reserved.


Jafari-Koshki T.,Sabzevar School of Medical Sciences | Jafari-Koshki T.,Isfahan University of Medical Sciences | Mansourian M.,Isfahan University of Medical Sciences | Mokarian F.,Isfahan University of Medical Sciences
Asian Pacific Journal of Cancer Prevention | Year: 2014

Background: Breast cancer is a fatal disease and the most frequently diagnosed cancer in women with an increasing pattern worldwide. The burden is mostly attributed to metastatic cancers that occur in one-third of patients and the treatments are palliative. It is of great interest to determine factors affecting time from cancer diagnosis to secondary metastasis. Materials and Methods: Cure rate models assume a Poisson distribution for the number of unobservable metastatic-component cells that are completely deleted from the non-metastasis patient body but some may remain and result in metastasis. Time to metastasis is defined as a function of the number of these cells and the time for each cell to develop a detectable sign of metastasis. Covariates are introduced to the model via the rate of metastatic-component cells. We used non-mixture cure rate models with Weibull and log-logistic distributions in a Bayesian setting to assess the relationship between metastasis free survival and covariates. Results: The median of metastasis free survival was 76.9 months. Various models showed that from covariates in the study, lymph node involvement ratio and being progesterone receptor positive were significant, with an adverse and a beneficial effect on metastasis free survival, respectively. The estimated fraction of patients cured from metastasis was almost 48%. The Weibull model had a slightly better performance than log-logistic. Conclusions: Cure rate models are popular in survival studies and outperform other models under certain conditions. We explored the prognostic factors of metastatic breast cancer from a different viewpoint. In this study, metastasis sites were analyzed all together. Conducting similar studies in a larger sample of cancer patients as well as evaluating the prognostic value of covariates in metastasis to each site separately are recommended.


Golmohammadi R.,Sabzevar School of Medical Sciences | Pejhan A.,Sabzevar School of Medical Sciences
Journal of the Pakistan Medical Association | Year: 2012

Objective: To investigate and compare the prognostic value of P53 and Ki67 markers in patients with breast cancer in Sabzevar, north east of Iran. Methods: A descriptive analytical study was conducted on 80 patients with breast cancer who were admitted to the hospitals in Sabzevar in 2006 and they were followed up to 2010. The expression of ki67 and stability of p53 genes were determined by immunohistochemistry. To assess the disease prognosis, patients were followed up to 48 months. Data were analyzed using SPSS software version 11.5. Chi-square, Fisher's exact test, Kaplan- Miere and Log Rank tests were used for statistical purposes. Results: Eighty cancerous tissue samples were examined. The Ki67 marker was present in 37 (46.3%) cases and the P53 protein stability in 39 (48.8%) cases were observed. There was a significant relationship between ki67 gene expression and tumour stage (p = 0.001) or tumour type (P = 0.02). There was also a significant relationship between the survival rate and the tumor stage (P = 0.008). The Ki67 marker had significant relationship with the survival rate (P = 0.031), but over expression of P53 protein did not show such significance (P = 0.385). Conclusion: The results showed that the Ki67 marker was more important than P53 protein in prognosis of the breast cancer patients.


Zadeh H.G.,Hakim Sabzevari University | Haddadnia J.,Hakim Sabzevari University | Hashemian M.,Sabzevar School of Medical Sciences | Hassanpour K.,Sabzevar School of Medical Sciences
Iranian Journal of Medical Physics | Year: 2012

Introduction: This study is an effort to diagnose breast cancer by processing the quantitative and qualitative information obtained from medical infrared imaging. The medical infrared imaging is free from any harmful radiation and it is one of the best advantages of the proposed method. By analyzing this information, the best diagnostic parameters among the available parameters are selected and its sensitivity and precision in cancer diagnosis is improved by utilizing genetic algorithm and artificial neural network. Materials and Methods: In this research, the necessary information is obtained from thermal imaging of 200 people, and 8 diagnostic parameters are extracted from these images by the research team. Then these 8 parameters are used as input of our proposed combinatorial model which is formed using artificial neural network and genetic algorithm. Results: Our results have revealed that comparison of the breast areas; thermal pattern and kurtosis are the most important parameters in breast cancer diagnosis from proposed medical infrared imaging. The proposed combinatorial model with a 50% sensitivity, 75% specificity and, 70% accuracy shows good precision in cancer diagnosis. Conclusion: The main goal of this article is to describe the capability of infrared imaging in preliminary diagnosis of breast cancer. This method is beneficial to patients with and without symptoms. The results indicate that the proposed combinatorial model produces optimum and efficacious parameters in comparison to other parameters and can improve the capability and power of globalizing the artificial neural network. This will help physicians in more accurate diagnosis of this type of cancer.

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