Pujar S.,S Nijalingappa Medical College Navanagara |
Kashinakunti S.V.,S Nijalingappa Medical College Navanagara |
Kallaganad G.S.,S Nijalingappa Medical College Navanagara |
Dambal A.,S Nijalingappa Medical College Navanagara |
Doddamani G.B.,S Nijalingappa Medical College
Journal of Clinical and Diagnostic Research | Year: 2010
Background: Oxidative stress and the influence of free radicals and their metabolites decrease the serum antioxidant status. They play a very important role in the pathogenesis of liver disease. The aim of the present study is to assess the Deritis in alcoholic and nonalcoholic liver disease patients in comparison to healthy controls and to evaluate its significance as a prognostic marker of liver disease. Methods: 100 cases were studied, of which 50 were normal healthy controls, 10 were alcoholic hepatitis patients, 10 were non-alcoholic hepatitis patients, 10 were alcoholic cirrhosis patients and 20 were non-alcoholic cirrhosis patients. Serum AST and ALT levels were estimated in all subjects by using commercial kits from CPC diagnostics (Raichem USA). The readings were taken on a semiautoanalyser (STATFAX 3300). Statistical analysis was done by using the Student's 't' test. Results: The Deritis was significantly increased in patients with alcoholic hepatitis and cirrhosis as compared to non-alcoholic hepatitis and cirrhosis patients, respectively (P<0.05). Further, significantly elevated Deritis was observed in non-alcoholic hepatitis and cirrhosis patients as compared to healthy controls (P<0.001). Conclusion: The findings of the present study are consistent with previous studies, suggesting that hepatocyte damage causes leak of these enzymes into the circulation. This study concludes that Deritis is a dependable marker of alcoholic liver disease.