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Shashikala G.V.,S Nijalingappa Medical College and HSK Hospital | Shashidhar P.K.,S Nijalingappa Medical College | Herur A.,S Nijalingappa Medical College and HSK Hospital | Chinagudi S.,S Nijalingappa Medical College and HSK Hospital | And 3 more authors.
Journal of Clinical and Diagnostic Research | Year: 2014

Background: Anaemia affects the body by decreased oxygen (O2) carrying capacity of the blood. There is growing evidence that anaemia contributes to cardiac disease and death. It causes O2 supply - demand myocardial mismatch causing myocardial ischemia. There is diversity of opinion available in literature on reports of electrocardiographic (ECG) changes in anaemia. Aim: To study the ECG changes in anemic population and to correlate ECG changes seen with increasing severity of anaemia. Materials and Methods: In hundred anemic adults, haemoglobin level and resting ECG were recorded. They were grouped according to haemoglobin level. ECG findings and varying severity of haemoglobin (Hb) level of each group were correlated using Pearson's co-relation co-efficient and association was calculated using Chi-square test. Results: ECG changes in patients with Hb level of 0-5gm% showed ST segment depression in 50-75%, T wave changes in 29-50% and Left Ventricular Hypertrophy (LVH) in 25-30% of patients. Less percentage of patients with 5-7gm% Hb showed such changes, and patients with 7-8gm% Hb, showed no changes. As the Hb level decreased there was more percentage of patients having tachycardia and ECG changes. There was a strong negative correlation between Hb level and tachycardia and ECG changes. Conclusion: Diagnosing anaemia in critical care can be supported by ECG changes like ST depression, T wave changes, with/ without associated QRS abnormalities to avoid misdiagnosis and also as dramatic clinical and ECG recovery can be achieved with anaemia correction.

Patted S.M.,S Nijalingappa Medical College and HSK Hospital | Chinagudi S.,S Nijalingappa Medical College and HSK Hospital | Soragavi V.R.,S Nijalingappa Medical College and HSK Hospital | Bhavi S.B.,S Nijalingappa Medical College and HSK Hospital
Biomedical Research (India) | Year: 2013

The incidence of methicillin-resistant Staphylococcus aureus (MRSA) infection is increasing world-wide. Vancomycin is one of the drug of choice for MRSA infection. The resistance to vancomycin in Staph. aureus, which was once thought to be very less, is also on a rise. So the present study aimed to find out the prevalence rate of MRSA infection and vancomycin resistance in patients admitted to orthopedic wards. We analysed the data of patients admitted for orthopedic care in a medical college hospital requiring bacterial culture-sensitivity study for either a suspected or an obvious infection between September 2007 and August 2009 in a retrospective observational study. The specimens were collected by either sterile cotton swab stick, an aspirate or the tissue obtained at surgery. The specimens were studied as per the standard protocol of the institute to note the organism grown and sensitivity to antibiotics. There were 1207 admissions to orthopedic wards between September 2007 and August 2009.A total of 131 specimens collected from 115 patients were studied, yielding 81growths. Staph. aureus was isolated in 38 specimens of which 24(63%) were MRSA and 6(25%) of these MRSA were resistant to vancomycin. The prevalence of MRSA infection was 1.99% (24/1207) and that of vancomycin resistant Staph. aureus infection was 1.07% (13/1207) of total orthopedic admissions. The prevalence rate of MRSA infection and development of resistance to vancomycin is alarmingly high. There is need for increased awareness regarding incidence, pathogenicity, preventive and treatment measures of MRSA.

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